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anti-C5AR2 antibody :: Rabbit C5AR2 / GPR77 / C5L2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241314
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C5AR2 / GPR77 / C5L2, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human C5AR2 / GPR77 / C5L2

 Product Synonym Names    Anti-C5AR2 / GPR77 / C5L2 Antibody (C-Terminus) IHC-plus; C5AR2; G-protein coupled receptor 77; GPF77; GPR77; C5L2; G protein-coupled receptor 77; Human C5AR2; GPR77; C5L2
 Product Gene Name   

anti-C5AR2 antibody

[Similar Products]
 Product Synonym Gene Name    GPR77; C5L2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609949
 3D Structure    ModBase 3D Structure for Q9P296
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
Predicted Reactivity: Gorilla, Monkey (at least 90% immunogen sequence identity)
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 Specificity    Human C5L2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 20 amino acid peptide from C-terminal cytoplasmic domain of human C5L2. Percent identity with other species by BLAST analysis: Human (100%); Gorilla (95%); Monkey (90%); Marmoset (85%).
 Immunogen Type    Synthetic peptide
 Immunogen    C5AR2 / GPR77 / C5L2 antibody was raised against synthetic 20 amino acid peptide from C-terminal cytoplasmic domain of human C5L2. Percent identity with other species by BLAST analysis: Human (100%); Gorilla (95%); Monkey (90%); Marmoset (85%).
 Antigen Modification    C-Terminus
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-C5AR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-C5AR2 antibody

   GPR77 is an Anaphylatoxin Receptor. Binding to anaphylatoxins can result in increased triglyceride synthesis, although its precise role in cellular responses has not been determined.
 Product Categories/Family for anti-C5AR2 antibody    Family: GPCR
Subfamily: Anaphylatoxin
 Applications Tested/Suitable for anti-C5AR2 antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-C5AR2 antibody    ELISA, IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-C5AR2 antibody    Anti-C5L2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-C5AR2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for C5AR2. It may not necessarily be applicable to this product.
 NCBI GI #    8923873
 NCBI GeneID    27202
 NCBI Accession #    NP_060955.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_018485.2 [Other Products]
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 UniProt Primary Accession #    Q9P296 [Other Products]
 UniProt Secondary Accession #    B2RA09 [Other Products]
 UniProt Related Accession #    Q9P296 [Other Products]
 Molecular Weight    36,080 Da
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 NCBI Official Full Name    C5a anaphylatoxin chemotactic receptor 2
 NCBI Official Synonym Full Names    complement component 5a receptor 2
 NCBI Official Symbol    C5AR2 [Similar Products]
 NCBI Official Synonym Symbols   
C5L2; GPF77; GPR77
[Similar Products]
 NCBI Protein Information    C5a anaphylatoxin chemotactic receptor 2; G protein-coupled receptor 77; G protein-coupled receptor C5L2; C5a anaphylatoxin chemotactic receptor C5L2
 UniProt Protein Name    C5a anaphylatoxin chemotactic receptor 2
 UniProt Synonym Protein Names   
Complement component 5a receptor 2; G-protein coupled receptor 77
 Protein Family    C5a anaphylatoxin chemotactic receptor
 UniProt Gene Name    C5AR2 [Similar Products]
 UniProt Synonym Gene Names    C5L2; GPR77 [Similar Products]
 UniProt Entry Name    C5AR2_HUMAN
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 NCBI Summary for C5AR2    This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
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 UniProt Comments for C5AR2    C5AR2: Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: apical part of cell; basal plasma membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; C5a anaphylatoxin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of tumor necrosis factor production; chemotaxis; inflammatory response; positive regulation of epithelial cell proliferation
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 Research Articles on C5AR2    1. The present study has extended the mutation spectrum of C5L2, and Thr196Asn mutations in C5L2 were associated with retinitis pigmentosa and serum lipid levels.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-C5AR2 antibodyPathways associated with anti-C5AR2 antibody
 Reference Product  PubMed Publications
 C5AR1 antibody  >4 publications with C5AR2 and C5AR1
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with anti-C5AR2 antibodyOrgans/Tissues associated with anti-C5AR2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with C5AR2 and Inflammation
 Necrosis Antibodies  >1 publications with C5AR2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with C5AR2 and Brain
 Blood Antibodies  >3 publications with C5AR2 and Blood
 Liver Antibodies  >1 publications with C5AR2 and Liver
 Spleen Antibodies  >1 publications with C5AR2 and Spleen
 Heart Antibodies  >1 publications with C5AR2 and Heart
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