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anti-Mb21d1 antibody :: Rabbit anti-Mouse, Rat C6orf150 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS540138
Immunohistochemistry (IHC)
Unit / Price
0.1 mg Affinity-Purified  /  $425 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C6orf150 (Mb21d1), Polyclonal Antibody

★Popular Item★
 Also Known As   

C6orf150 Antibody

 Product Synonym Names    C6orf150; cGAMP synthase; cGAS; Chromosome 6 open reading frame 150; Cyclic GMP-AMP synthase; h-cGAS; Hypothetical protein LOC115004; Mab 21 domain containing 1; MB21D1; protein MB21D1; Uncharacterized protein C6orf150 antibody
 Product Gene Name   

anti-Mb21d1 antibody

[Similar Products]
 Matching Pairs    Antibody: C6orf150 (MBS540138)
Positive Control: C6orf150 (MBS542627)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q8C6L5
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Mouse, Rat
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 Form/Format    Affinity Purified
 Concentration    0.60 ug/ul in antibody stabilization buffer (lot specific)
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 Immunogen    Synthetic peptide taken within amino acid region 450-500 on mouse cGAS protein.
 Expression    Is expressed in the monocytic cell line THP1 by type 1 Interferons
 Molecular Function    Nucleotidyltransferase; ATP binding; DNA binding
 Structure    Monomer when in absence of DNA. Homodimer when bound to DNA.
 Subcellular Location    Cytoplasm; Cytosol
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-Mb21d1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Mb21d1 antibody

   Affinity Purified Cyclic GMP-AMP synthase Antibody
Catalyzes the formation of cyclic GMP-AMP from ATP and GTP. Has antiviral activity through acting as a cystolic DNA senser.
 Product Categories/Family for anti-Mb21d1 antibody    Primary Antibodies; Signal Transduction; Second Messengers; cGMP; C6orf150 Antibody
 Applications Tested/Suitable for anti-Mb21d1 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-Mb21d1 antibody    Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:150
Western Blot: 1:500
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 Immunohistochemistry (IHC) of anti-Mb21d1 antibody    anti-Mb21d1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for Mb21d1. It may not necessarily be applicable to this product.
 NCBI GI #    116812912
 NCBI GeneID    214763
 NCBI Accession #    NP_775562 [Other Products]
 NCBI GenBank Nucleotide #    NM_173386.5 [Other Products]
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 UniProt Primary Accession #    Q8C6L5 [Other Products]
 UniProt Secondary Accession #    Q3ULW3 [Other Products]
 UniProt Related Accession #    Q8C6L5 [Other Products]
 Molecular Weight    58,194 Da [Similar Products]
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 NCBI Official Full Name    cyclic GMP-AMP synthase
 NCBI Official Synonym Full Names    Mab-21 domain containing 1
 NCBI Official Symbol    Mb21d1 [Similar Products]
 NCBI Official Synonym Symbols   
cGAS; E330016A19Rik
[Similar Products]
 NCBI Protein Information    cyclic GMP-AMP synthase
 UniProt Protein Name    Cyclic GMP-AMP synthase
 UniProt Synonym Protein Names   
2'3'-cGAMP synthase; Mab-21 domain-containing protein 1
 Protein Family    Cyclic GMP-AMP synthase
 UniProt Gene Name    Mb21d1 [Similar Products]
 UniProt Synonym Gene Names    cGAMP synthase; cGAS; m-cGAS [Similar Products]
 UniProt Entry Name    CGAS_MOUSE
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 NCBI Summary for Mb21d1    The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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 UniProt Comments for Mb21d1    MB21D1: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.

Protein type: Enzyme, cellular metabolism; EC 2.7.7.86

Cellular Component: cytoplasm; cytosol

Molecular Function: ATP binding; DNA binding; GTP binding; metal ion binding; nucleotide binding; nucleotidyltransferase activity; transferase activity

Biological Process: activation of innate immune response; cyclic nucleotide biosynthetic process; defense response to virus; immune system process; innate immune response; positive regulation of defense response to virus by host
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 Research Articles on Mb21d1    1. cGAS is an innate sensor of Mycobacterium tuberculosis.Mycobacterium tuberculosis differentially activates cGAS- and inflammasome-dependent intracellular immune responses through ESX-1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Mb21d1 antibodyDiseases associated with anti-Mb21d1 antibody
 Products by Pathway  Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >3 publications with Mb21d1 and Neoplasms, Experimental
 Inflammation Antibodies  >3 publications with Mb21d1 and Inflammation
 Sarcoma Antibodies  >2 publications with Mb21d1 and Sarcoma
 Mitochondrial Diseases Antibodies  >1 publications with Mb21d1 and Mitochondrial Diseases
 Poisoning Antibodies  >1 publications with Mb21d1 and Poisoning
 Necrosis Antibodies  >1 publications with Mb21d1 and Necrosis
Organs/Tissues associated with anti-Mb21d1 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >3 publications with Mb21d1 and Bone Marrow
 Embryonic Tissue Antibodies  >1 publications with Mb21d1 and Embryonic Tissue
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