NP_000057.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated Molecular Weight: 67kDa Observed Molecular Weight: 70kDa
NCBI Official Full Name
complement component C8 beta chain isoform 1 preproprotein
NCBI Official Synonym Full Names
complement C8 beta chain
NCBI Official Synonym Symbols
NCBI Protein Information
complement component C8 beta chain
UniProt Protein Name
Complement component C8 beta chain
UniProt Synonym Protein Names
Complement component 8 subunit beta
NCBI Summary for C8 beta
This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
UniProt Comments for C8 beta
C8B: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C8B are a cause of complement component 8 deficiency type 2 (C8D2). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p32.2
Cellular Component: extracellular region; membrane; membrane attack complex
Molecular Function: protein complex binding
Biological Process: complement activation; complement activation, alternative pathway; complement activation, classical pathway; cytolysis; immune response; regulation of complement activation
Disease: Complement Component 8 Deficiency, Type Ii
Research Articles on C8 beta
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Products associated with anti-C8 beta antibody
Pathways associated with anti-C8 beta antibody
Diseases associated with anti-C8 beta antibody
Organs/Tissues associated with anti-C8 beta antibody
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