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anti-CA4 antibody :: Rabbit anti-Human, Mouse CA4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS127739
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CA4, Polyclonal Antibody

 Also Known As   

CA4 Polyclonal Antibody

 Product Synonym Names    CAIV; Car4; RP17
 Product Gene Name   

anti-CA4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 600852
 3D Structure    ModBase 3D Structure for P22748
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human CA4
 Calculated Molecular Weight    35kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-CA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CA4 antibody

   Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. [provided by RefSeq, Jul 2008]
 Product Categories/Family for anti-CA4 antibody    Polyclonal
 Applications Tested/Suitable for anti-CA4 antibody   

Western Blot (WB)

 Application Notes for anti-CA4 antibody    WB: 1:500 - 1:1000
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 Western Blot (WB) of anti-CA4 antibody    Western blot analysis of extracts of mouse fetal lung tissue lysate, using CA4 antibody.
anti-CA4 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC of anti-CA4 antibody    Immunohistochemistry of paraffin-embedded human kidney cancer tissue using CA4 antibody at dilution of 1:200 (x400 lens)
anti-CA4 antibody Immunohistochemistry (IHC (IHC) image
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NCBI/Uniprot data below describe general gene information for CA4. It may not necessarily be applicable to this product.
 NCBI GI #    115465
 NCBI GeneID    762
 NCBI Accession #    P22748.2 [Other Products]
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 UniProt Primary Accession #    P22748 [Other Products]
 UniProt Secondary Accession #    Q6FHI7; B4DQA4 [Other Products]
 UniProt Related Accession #    P22748 [Other Products]
 Molecular Weight    312
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 NCBI Official Full Name    Carbonic anhydrase 4
 NCBI Official Synonym Full Names    carbonic anhydrase IV
 NCBI Official Symbol    CA4 [Similar Products]
 NCBI Official Synonym Symbols   
CAIV; Car4; RP17
[Similar Products]
 NCBI Protein Information    carbonic anhydrase 4; CA-IV; carbonic dehydratase IV; carbonate dehydratase IV
 UniProt Protein Name    Carbonic anhydrase 4
 UniProt Synonym Protein Names   
Carbonate dehydratase IV; Carbonic anhydrase IV; CA-IV
 Protein Family    Carbonic anhydrase
 UniProt Gene Name    CA4 [Similar Products]
 UniProt Synonym Gene Names    CA-IV [Similar Products]
 UniProt Entry Name    CAH4_HUMAN
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 NCBI Summary for CA4    Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CA4    CA4: Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid. Defects in CA4 are the cause of retinitis pigmentosa type 17 (RP17). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP17 inheritance is autosomal dominant. Defective acid overload removal from retina and retinal epithelium, due to mutant CA4, is responsible for photoreceptor degeneration, indicating that impaired pH homeostasis is the most likely cause underlying the RP17 phenotype. Belongs to the alpha-carbonic anhydrase family.

Protein type: Lyase; Energy Metabolism - nitrogen; Membrane protein, GPI anchor; EC 4.2.1.1

Chromosomal Location of Human Ortholog: 17q23

Cellular Component: Golgi apparatus; cell surface; sarcoplasmic reticulum; rough endoplasmic reticulum; basolateral plasma membrane; brush border membrane; secretory granule membrane; ER-Golgi intermediate compartment; trans-Golgi network; anchored to external side of plasma membrane; membrane; perinuclear region of cytoplasm; apical plasma membrane; plasma membrane; sarcolemma

Molecular Function: carbonate dehydratase activity; protein binding; zinc ion binding

Biological Process: response to drug; response to steroid hormone stimulus; bicarbonate transport; organ development; one-carbon compound metabolic process

Disease: Retinitis Pigmentosa 17
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 Research Articles on CA4    1. Carbonic anhydrase 4 is lost in papillary thyroid carcinoma but not thyroid nodules
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CA4 antibodyPathways associated with anti-CA4 antibody
 Reference Product  PubMed Publications
 FSCN2 antibody  >2 publications with CA4 and FSCN2
 SLC4A3 antibody  >2 publications with CA4 and SLC4A3
 SLC4A4 antibody  >2 publications with CA4 and SLC4A4
 Products by Pathway  Pathway Diagram
 Erythrocytes Take Up Carbon Dioxide And Release Oxygen Pathway antibodies  Erythrocytes Take Up Carbon Dioxide And Release Oxygen Pathway Diagram
 Erythrocytes Take Up Oxygen And Release Carbon Dioxide Pathway antibodies  Erythrocytes Take Up Oxygen And Release Carbon Dioxide Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Nitrogen Metabolism Pathway antibodies  Nitrogen Metabolism Pathway Diagram
 Nitrogen Metabolism Pathway antibodies  Nitrogen Metabolism Pathway Diagram
 O2/CO2 Exchange In Erythrocytes Pathway antibodies  O2/CO2 Exchange In Erythrocytes Pathway Diagram
 Proximal Tubule Bicarbonate Reclamation Pathway antibodies  Proximal Tubule Bicarbonate Reclamation Pathway Diagram
 Proximal Tubule Bicarbonate Reclamation Pathway antibodies  Proximal Tubule Bicarbonate Reclamation Pathway Diagram
 Reversible Hydration Of Carbon Dioxide Pathway antibodies  Reversible Hydration Of Carbon Dioxide Pathway Diagram
Diseases associated with anti-CA4 antibodyOrgans/Tissues associated with anti-CA4 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >422 publications with CA4 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >136 publications with CA4 and Cardiovascular Diseases
 Brain Ischemia Antibodies  >126 publications with CA4 and Brain Ischemia
 Nerve Degeneration Antibodies  >77 publications with CA4 and Nerve Degeneration
 Disease Models, Animal Antibodies  >56 publications with CA4 and Disease Models, Animal
 Necrosis Antibodies  >40 publications with CA4 and Necrosis
 Cerebral Infarction Antibodies  >32 publications with CA4 and Cerebral Infarction
 Stroke Antibodies  >29 publications with CA4 and Stroke
 Brain Injuries Antibodies  >28 publications with CA4 and Brain Injuries
 Atrophy Antibodies  >21 publications with CA4 and Atrophy
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >936 publications with CA4 and Brain
 Blood Antibodies  >144 publications with CA4 and Blood
 Ganglia Antibodies  >22 publications with CA4 and Ganglia
 Heart Antibodies  >21 publications with CA4 and Heart
 Muscle Antibodies  >20 publications with CA4 and Muscle
 Bone Antibodies  >18 publications with CA4 and Bone
 Eye Antibodies  >15 publications with CA4 and Eye
 Kidney Antibodies  >14 publications with CA4 and Kidney
 Connective Tissue Antibodies  >6 publications with CA4 and Connective Tissue
 Prostate Antibodies  >4 publications with CA4 and Prostate
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