NP_064632.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,537 Da
NCBI Official Full Name
chaperone activity of bc1 complex-like, mitochondrial
NCBI Official Synonym Full Names
aarF domain containing kinase 3
NCBI Official Synonym Symbols
COQ8; ARCA2; CABC1; SCAR9; COQ10D4 [Similar Products]
NCBI Protein Information
chaperone activity of bc1 complex-like, mitochondrial; coenzyme Q8 homolog; aarF domain-containing protein kinase 3; chaperone, ABC1 activity of bc1 complex homolog
UniProt Protein Name
Chaperone activity of bc1 complex-like, mitochondrial
UniProt Synonym Protein Names
aarF domain-containing protein kinase 3
UniProt Synonym Gene Names
UniProt Entry Name
ADCK3_HUMAN
NCBI Summary for ADCK3
This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for ADCK3
ADCK3: May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain. Defects in ADCK3 are the cause of coenzyme Q10 deficiency, primary, type 4 (COQ10D4). An autosomal recessive disorder characterized by childhood-onset of cerebellar ataxia and exercise intolerance. Patient manifest gait ataxia and cerebellar atrophy with slow progression. Additional features include brisk tendon reflexes and Hoffmann sign, variable psychomotor retardation and variable seizures. Belongs to the protein kinase superfamily. ADCK protein kinase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.11.-; Protein kinase, atypical; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; ATYPICAL group; ABC1 family; ABC1-A subfamily
Chromosomal Location of Human Ortholog: 1q42.13
Cellular Component: mitochondrion
Molecular Function: protein serine/threonine kinase activity; ATP binding
Biological Process: ubiquinone biosynthetic process; protein amino acid phosphorylation
Disease: Coenzyme Q10 Deficiency, Primary, 4
Research Articles on ADCK3
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Diseases associated with anti-ADCK3 antibody
Organs/Tissues associated with anti-ADCK3 antibody
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