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anti-CABLES1 antibody :: Rabbit CABLES1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2520197
Immunohistochemistry (IHC)
Unit / Price
0.06 mL  /  $200 +1 FREE 8GB USB
0.12 mL  /  $275 +1 FREE 8GB USB
0.2 mL  /  $440 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CABLES1, Polyclonal Antibody

 Also Known As   

CABLES1 Polyclonal Antibody

 Product Synonym Names    CABL1; IK3-1; CABLES; HsT2563
 Product Gene Name   

anti-CABLES1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609194
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    0.7mg/mL (lot specific)
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 Immunogen    Recombinant protein of human CABLES1
 Calculated Molecular Weight: 68kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-CABLES1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CABLES1 antibody

   This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127). Multiple transcript variants encoding different isoforms have been found for this gene.
 Applications Tested/Suitable for anti-CABLES1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CABLES1 antibody    WB: 1:500-1:2000
IHC: 1:25-1:100
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 Immunohistochemistry (IHC) of anti-CABLES1 antibody    Immunohistochemistry of Human prostate cancer using CABLES1 Polyclonal Antibody at dilution of 1:15
anti-CABLES1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CABLES1. It may not necessarily be applicable to this product.
 NCBI GI #    374253774
 NCBI GeneID    91768
 NCBI Accession #    NP_001243367.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256438.1 [Other Products]
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 UniProt Secondary Accession #    Q8N3Y8; Q8NA22; Q9BTG1; B4DK60 [Other Products]
 UniProt Related Accession #    Q8TDN4 [Other Products]
 Molecular Weight    34,593 Da
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 NCBI Official Full Name    CDK5 and ABL1 enzyme substrate 1 isoform 3
 NCBI Official Synonym Full Names    Cdk5 and Abl enzyme substrate 1
 NCBI Official Symbol    CABLES1 [Similar Products]
 NCBI Official Synonym Symbols   
CABL1; IK3-1; CABLES; HsT2563
[Similar Products]
 NCBI Protein Information    CDK5 and ABL1 enzyme substrate 1; interactor with CDK3 1
 UniProt Protein Name    CDK5 and ABL1 enzyme substrate 1
 UniProt Synonym Protein Names   
Interactor with CDK3 1; Ik3-1
 Protein Family    CDK5 and ABL1 enzyme substrate
 UniProt Gene Name    CABLES1 [Similar Products]
 UniProt Synonym Gene Names    CABLES; Ik3-1 [Similar Products]
 UniProt Entry Name    CABL1_HUMAN
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 NCBI Summary for CABLES1    This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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 UniProt Comments for CABLES1    CABLES1: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death. Belongs to the cyclin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 18q11.2

Cellular Component: cytosol; nucleus

Molecular Function: protein binding

Biological Process: nervous system development; cell division; blood coagulation; cell cycle
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 Research Articles on CABLES1    1. The results did not detect a significant association. It indicated that common genetic variations in CDK5 genes might not play a role in the genetic predisposition to autism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to CABLES1 Polyclonal Antibody
 Catalog #  Product Name  Catalog #  Product Name
 MBS2520197  CABLES1 Polyclonal Antibody  MBS9411956  Cables1 Polyclonal Antibody
 MBS645949  CABLES1 (CDK5 and ABL1 Enzyme Substrate 1, Interactor with CDK3 1, Ik3-1, CABLES)  MBS7226941  Rabbit CDK5 and ABL1 enzyme subste 1 (CABLES1) ELISA Kit
 MBS7249661  Goat CDK5 and ABL1 enzyme subste 1 (CABLES1) ELISA Kit  MBS8201597  CABLES1 siRNA (Mouse)
 MBS7221870  Sheep CDK5 and ABL1 enzyme subste 1 (CABLES1) ELISA Kit  MBS7203086  Bovine CDK5 and ABL1 enzyme subste 1 (CABLES1) ELISA Kit
 MBS7244986  Canine CDK5 and ABL1 enzyme subste 1 (CABLES1) ELISA Kit  MBS7205136  Human CDK5 and ABL1 enzyme subste 1 (CABLES1) ELISA Kit
Products associated with anti-CABLES1 antibodyPathways associated with anti-CABLES1 antibody
 Reference Product  PubMed Publications
 CDK5 antibody  >8 publications with CABLES1 and CDK5
 CDK2 antibody  >5 publications with CABLES1 and CDK2
 WEE1 antibody  >2 publications with CABLES1 and WEE1
 CTNNB1 antibody  >1 publications with CABLES1 and CTNNB1
 Products by Pathway  Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-CABLES1 antibodyOrgans/Tissues associated with anti-CABLES1 antibody
 Disease Name  Pubmed Publications
 Colorectal Neoplasms Antibodies  >6 publications with CABLES1 and Colorectal Neoplasms
 Ovarian Diseases Antibodies  >3 publications with CABLES1 and Ovarian Diseases
 Ovarian Neoplasms Antibodies  >3 publications with CABLES1 and Ovarian Neoplasms
 Hyperplasia Antibodies  >2 publications with CABLES1 and Hyperplasia
 Cell Transformation, Neoplastic Antibodies  >1 publications with CABLES1 and Cell Transformation, Neoplastic
 Precancerous Conditions Antibodies  >1 publications with CABLES1 and Precancerous Conditions
 Breast Neoplasms Antibodies  >1 publications with CABLES1 and Breast Neoplasms
 Nervous System Malformations Antibodies  >1 publications with CABLES1 and Nervous System Malformations
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with CABLES1 and Lung
 Brain Antibodies  >4 publications with CABLES1 and Brain
 Vascular Antibodies  >3 publications with CABLES1 and Vascular
 Testis Antibodies  >1 publications with CABLES1 and Testis
 Embryonic Tissue Antibodies  >1 publications with CABLES1 and Embryonic Tissue
 Kidney Antibodies  >1 publications with CABLES1 and Kidney
 Bone Antibodies  >1 publications with CABLES1 and Bone
 Uterus Antibodies  >1 publications with CABLES1 and Uterus
 Pancreas Antibodies  >1 publications with CABLES1 and Pancreas
 Skin Antibodies  >1 publications with CABLES1 and Skin
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