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anti-CACNA1C antibody :: Rabbit CACNA1C / Cav1.2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242968
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CACNA1C / Cav1.2, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human CACNA1C / Cav1.2

 Product Synonym Names    Anti-CACNA1C / Cav1.2 Antibody (Internal) IHC-plus; CACNA1C; Alpha 1c; CaV1.2; CACH2; CACNL1A1; CCHL1A1; DHPR; alpha-1 subunit; DHP receptor; DHPr; LQT8; TS; CACN2; Human CACNA1C; Cav1.2
 Product Gene Name   

anti-CACNA1C antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 611875
 3D Structure    ModBase 3D Structure for Q13936
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gibbon, Human
Predicted Reactivity: Gorilla, Monkey (at least 90% immunogen sequence identity)
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 Specificity    Human CACNA1C / Cav1.2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 16 amino acid peptide from internal region of human CACNA1C / Cav1.2. Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Gorilla, Monkey, Marmoset (94%).
 Immunogen Type    Synthetic peptide
 Immunogen    CACNA1C / Cav1.2 antibody was raised against synthetic 16 amino acid peptide from internal region of human CACNA1C / Cav1.2. Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Gorilla, Monkey, Marmoset (94%).
 Antigen Modification    Internal
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-CACNA1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CACNA1C antibody

   Cacna1c is the cardiac alpha Cav1 subunit of the voltage-gated calcium channel. Cacna1c is responsible for calcium influx during contraction and calcium homeostasis in cardiac muscle. At least two isoforms are produced by alternative splicing.
 Product Categories/Family for anti-CACNA1C antibody    Family: Ion Channel
Subfamily: Calcium channel - alpha subunit Cav1
 Applications Tested/Suitable for anti-CACNA1C antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-CACNA1C antibody    IHC-P (2.5 ug/ml)
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 Immunohistochemistry (IHC) of anti-CACNA1C antibody    Anti-CACNA1C / Cav1.2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-CACNA1C antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CACNA1C. It may not necessarily be applicable to this product.
 NCBI GI #    120433602
 NCBI GeneID    775
 NCBI Accession #    NP_000710.5 [Other Products]
 NCBI GenBank Nucleotide #    NM_000719.6 [Other Products]
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 UniProt Primary Accession #    Q13936 [Other Products]
 UniProt Secondary Accession #    Q13917; Q13918; Q13919; Q13920; Q13921; Q13922; Q13923; Q13924; Q13925; B2RUT3; E9PDJ0 [Other Products]
 UniProt Related Accession #    Q13936 [Other Products]
 Molecular Weight    239,704 Da
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 NCBI Official Full Name    voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
 NCBI Official Synonym Full Names    calcium channel, voltage-dependent, L type, alpha 1C subunit
 NCBI Official Symbol    CACNA1C [Similar Products]
 NCBI Official Synonym Symbols   
TS; LQT8; CACH2; CACN2; CaV1.2; CCHL1A1; CACNL1A1
[Similar Products]
 NCBI Protein Information    voltage-dependent L-type calcium channel subunit alpha-1C; DHPR, alpha-1 subunit; voltage-dependent L-type Ca2+ channel alpha 1 subunit; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*
 UniProt Protein Name    Voltage-dependent L-type calcium channel subunit alpha-1C
 UniProt Synonym Protein Names   
Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; Voltage-gated calcium channel subunit alpha Cav1.2
 Protein Family    Voltage-dependent L-type calcium channel
 UniProt Gene Name    CACNA1C [Similar Products]
 UniProt Synonym Gene Names    CACH2; CACN2; CACNL1A1; CCHL1A1 [Similar Products]
 UniProt Entry Name    CAC1C_HUMAN
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 NCBI Summary for CACNA1C    This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]
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 UniProt Comments for CACNA1C    CACNA1C: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function. Defects in CACNA1C are the cause of Timothy syndrome (TS). TS is a disorder characterized by multiorgan dysfunction including lethal arrhythmias, webbing of fingers and toes, congenital heart disease, immune deficiency, intermittent hypoglycemia, cognitive abnormalities and autism. Defects in CACNA1C are the cause of Brugada syndrome type 3 (BRGDA3). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily. 35 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: cell soma; cytoplasm; postsynaptic density; caveolar macromolecular signaling complex; integral to membrane; plasma membrane; voltage-gated calcium channel complex; dendritic shaft; Z disc

Molecular Function: voltage-gated calcium channel activity; calmodulin binding; protein binding; enzyme binding; metal ion binding; high voltage-gated calcium channel activity; alpha-actinin binding

Biological Process: axon guidance; regulation of organ growth; glucose homeostasis; adult walking behavior; calcium ion-dependent exocytosis; growth hormone secretion; synaptic transmission; elevation of cytosolic calcium ion concentration; insulin secretion; smooth muscle contraction involved in micturition; regulation of vasoconstriction; regulation of blood pressure; energy reserve metabolic process; visual learning; regulation of insulin secretion

Disease: Timothy Syndrome; Brugada Syndrome 3
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 Research Articles on CACNA1C    1. Results indicate that alterations in functional coupling between prefrontal cortex and medial temporal lobe could represent neural system phenotype mediated by CACNA1C rs1006737 and other genetic susceptibility loci for schizophrenia and bipolar disorder
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CACNA1C antibodyDiseases associated with anti-CACNA1C antibody
 Products by Pathway  Pathway Diagram
 Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway antibodies  Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >89 publications with CACNA1C and Cardiovascular Diseases
 Bipolar Disorder Antibodies  >83 publications with CACNA1C and Bipolar Disorder
 Heart Diseases Antibodies  >80 publications with CACNA1C and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >65 publications with CACNA1C and Arrhythmias, Cardiac
 Timothy syndrome Antibodies  >32 publications with CACNA1C and Timothy syndrome
 Nervous System Diseases Antibodies  >32 publications with CACNA1C and Nervous System Diseases
 Heart Failure Antibodies  >18 publications with CACNA1C and Heart Failure
 Hypertension Antibodies  >17 publications with CACNA1C and Hypertension
 Limb Deformities, Congenital Antibodies  >16 publications with CACNA1C and Limb Deformities, Congenital
 Brugada Syndrome 3 Antibodies  >8 publications with CACNA1C and Brugada Syndrome 3
Organs/Tissues associated with anti-CACNA1C antibody
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >112 publications with CACNA1C and Heart
 Brain Antibodies  >99 publications with CACNA1C and Brain
 Lung Antibodies  >9 publications with CACNA1C and Lung
 Embryonic Tissue Antibodies  >8 publications with CACNA1C and Embryonic Tissue
 Liver Antibodies  >6 publications with CACNA1C and Liver
 Intestine Antibodies  >6 publications with CACNA1C and Intestine
 Eye Antibodies  >4 publications with CACNA1C and Eye
 Ovary Antibodies  >4 publications with CACNA1C and Ovary
 Ganglia Antibodies  >3 publications with CACNA1C and Ganglia
 Pancreas Antibodies  >3 publications with CACNA1C and Pancreas
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