NP_000710.5
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
NCBI Official Synonym Full Names
calcium voltage-gated channel subunit alpha1 C
NCBI Official Synonym Symbols
TS; LQT8; CACH2; CACN2; CaV1.2; CCHL1A1; CACNL1A1 [Similar Products]
NCBI Protein Information
voltage-dependent L-type calcium channel subunit alpha-1C
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit alpha-1C
UniProt Synonym Protein Names
Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; Voltage-gated calcium channel subunit alpha Cav1.2
UniProt Synonym Gene Names
NCBI Summary for CACNA1C
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]
UniProt Comments for CACNA1C
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.
Research Articles on CACNA1C
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Products associated with anti-CACNA1C antibody
Pathways associated with anti-CACNA1C antibody
Diseases associated with anti-CACNA1C antibody
Organs/Tissues associated with anti-CACNA1C antibody
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