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anti-CACNA1S antibody :: Rabbit anti-Human CACNA1S Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9404198
Unit / Price
0.1 mL  /  $320 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CACNA1S, Polyclonal Antibody

 Also Known As   

CACNA1S antibody

 Product Gene Name   

anti-CACNA1S antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    114208
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Purified by antigen-affinity chromatography.
 Form/Format    Supplied in 1XPBS, 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
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 Immunogen Type    Recombinant protein
 Immunogen Description    Recombinant protein fragment contain a sequence corresponding to a region within amino acids 544 and 855 of CACNA1S
 Target Name    CACNA1S
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 Preparation and Storage    Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.
 Other Notes    Small volumes of anti-CACNA1S antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CACNA1S antibody

   This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. [provided by RefSeq]
 Product Categories/Family for anti-CACNA1S antibody    Total protein Ab
 Applications Tested/Suitable for anti-CACNA1S antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CACNA1S antibody    Western blotting: 1:500-1:3000
Immunohistochemistry: 1:100-1:500
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 Testing Data of anti-CACNA1S antibody    Sample (30 ug of whole cell lysate) A: 293T 5% SDS PAGE Primary antibody diluted at 1: 1000
anti-CACNA1S antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-CACNA1S antibody    Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using CACNA1S antibody at 1: 100 dilution.
anti-CACNA1S antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CACNA1S. It may not necessarily be applicable to this product.
 NCBI GI #    110349767
 NCBI GeneID    779
 NCBI Accession #    NP_000060 [Other Products]
 NCBI GenBank Nucleotide #    NM_000069.2 [Other Products]
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 UniProt Secondary Accession #    Q12896; Q13934; A4IF51; B1ALM2 [Other Products]
 UniProt Related Accession #    Q13698 [Other Products]
 Molecular Weight    212,350 Da
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 NCBI Official Full Name    voltage-dependent L-type calcium channel subunit alpha-1S
 NCBI Official Synonym Full Names    calcium channel, voltage-dependent, L type, alpha 1S subunit
 NCBI Official Symbol    CACNA1S [Similar Products]
 NCBI Official Synonym Symbols   
MHS5; HOKPP; TTPP1; Cav1.1; HOKPP1; hypoPP; CCHL1A3; CACNL1A3
[Similar Products]
 NCBI Protein Information    voltage-dependent L-type calcium channel subunit alpha-1S
 UniProt Protein Name    Voltage-dependent L-type calcium channel subunit alpha-1S
 UniProt Synonym Protein Names   
Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; Voltage-gated calcium channel subunit alpha Cav1.1
 Protein Family    Voltage-dependent L-type calcium channel
 UniProt Gene Name    CACNA1S [Similar Products]
 UniProt Synonym Gene Names    CACH1; CACN1; CACNL1A3 [Similar Products]
 UniProt Entry Name    CAC1S_HUMAN
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 NCBI Summary for CACNA1S    This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CACNA1S    CACNA1S: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle. Defects in CACNA1S are the cause of periodic paralysis hypokalemic type 1 (HOKPP1); also designated HYPOPP. HOKPP1 is an autosomal dominant disorder manifested by episodic flaccid generalized muscle weakness associated with falls of serum potassium levels. Defects in CACNA1S are the cause of malignant hyperthermia susceptibility type 5 (MHS5); an autosomal dominant disorder that is potentially lethal in susceptible individuals on exposure to commonly used inhalational anesthetics and depolarizing muscle relaxants. Defects in CACNA1S are the cause of susceptibility to thyrotoxic periodic paralysis type 1 (TTPP1). A sporadic muscular disorder characterized by episodic weakness and hypokalemia during a thyrotoxic state. It is clinically similar to hereditary hypokalemic periodic paralysis, except for the fact that hyperthyroidism is an absolute requirement for disease manifestation. The disease presents with recurrent episodes of acute muscular weakness of the four extremities that vary in severity from paresis to complete paralysis. Attacks are triggered by ingestion of a high carbohydrate load or strenuous physical activity followed by a period of rest. Thyrotoxic periodic paralysis can occur in association with any cause of hyperthyroidism, but is most commonly associated with Graves disease. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1S subfamily.

Protein type: Membrane protein, multi-pass; Channel, calcium; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: I band; sarcoplasmic reticulum; T-tubule; cytoplasm; plasma membrane; voltage-gated calcium channel complex

Molecular Function: voltage-gated calcium channel activity; metal ion binding; high voltage-gated calcium channel activity

Biological Process: endoplasmic reticulum organization and biogenesis; axon guidance; striated muscle contraction; muscle contraction; calcium ion transport; skeletal muscle adaptation; skeletal muscle fiber development; extraocular skeletal muscle development; skeletal development; myoblast fusion; neuromuscular junction development

Disease: Malignant Hyperthermia, Susceptibility To, 5; Thyrotoxic Periodic Paralysis, Susceptibility To, 1; Hypokalemic Periodic Paralysis, Type 1
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 Research Articles on CACNA1S    1. The authors found one and three rare variants of unknown significance in CACNA1S in the Malignant Hyperthermia and Exertional Heat cohorts
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CACNA1S antibodyPathways associated with anti-CACNA1S antibody
 Reference Product  PubMed Publications
 RYR1 antibody  >50 publications with CACNA1S and RYR1
 CACNA1H antibody  >1 publications with CACNA1S and CACNA1H
 CACNA2D1 antibody  >1 publications with CACNA1S and CACNA2D1
 CACNB1 antibody  >1 publications with CACNA1S and CACNB1
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Diseases associated with anti-CACNA1S antibodyOrgans/Tissues associated with anti-CACNA1S antibody
 Disease Name  Pubmed Publications
 Hypokalemic Periodic Paralysis Antibodies  >68 publications with CACNA1S and Hypokalemic Periodic Paralysis
 HYPOKALEMIC PERIODIC PARALYSIS, TYPE 1 Antibodies  >13 publications with CACNA1S and HYPOKALEMIC PERIODIC PARALYSIS, TYPE 1
 Malignant hyperthermia susceptibility type 5 Antibodies  >5 publications with CACNA1S and Malignant hyperthermia susceptibility type 5
 Arrhythmias, Cardiac Antibodies  >5 publications with CACNA1S and Arrhythmias, Cardiac
 Weight Loss Antibodies  >2 publications with CACNA1S and Weight Loss
 Respiratory Insufficiency Antibodies  >2 publications with CACNA1S and Respiratory Insufficiency
 Weight Gain Antibodies  >1 publications with CACNA1S and Weight Gain
 Glucose Intolerance Antibodies  >1 publications with CACNA1S and Glucose Intolerance
 Hypertrophy Antibodies  >1 publications with CACNA1S and Hypertrophy
 Hyperplasia Antibodies  >1 publications with CACNA1S and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >112 publications with CACNA1S and Muscle
 Thyroid Antibodies  >5 publications with CACNA1S and Thyroid
 Liver Antibodies  >1 publications with CACNA1S and Liver
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