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anti-CACNB4 antibody :: Goat CACNB4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421064
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CACNB4, Polyclonal Antibody

 Also Known As   

Goat anti-CACNB4 (C terminus) Antibody

 Product Synonym Names    Goat Anti-CACNB4 (internal) Antibody; CACNB4; CAB4; CACNLB4; calcium channel, voltage-dependent, beta 4 subunit; dihydropyridine-sensitive L-type, calcium channel beta-4 subunit; EA5; EIG9; EJM; EJM4; EJM6; OTTHUMP00000207247; OTTHUMP00000207249; CACNB4 antibody; CAB4 antibody; CACNLB4 antibody; calcium channel; voltage-dependent; beta 4 subunit antibody; dihydropyridine-sensitive L-type; calcium channel beta-4 subunit antibody; CACNB4 (C terminus)
 Product Gene Name   

anti-CACNB4 antibody

[Similar Products]
 Antibody/Peptide Pairs    CACNB4 peptide (MBS428193) is used for blocking the activity of CACNB4 antibody (MBS421064)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    CSPGGYSHDS RHRL
 OMIM    601949
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Pig
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence CSPGGYSHDSRHRL, from the C Terminus of the protein sequence according to NP_001005747.1; NP_000717.2; NP_001005746.1.
 Epitope    C Terminus
 Note    This antibody is expected to recognise all reported protein isoforms of human CACNB4 (NP_001005747.1; NP_000717.2; NP_001005746.1;)
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CACNB4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CACNB4 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-CACNB4 antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx 60+55kDa bands observed in Human Bone Marrow lysates and in transfected HEK293 transiently expressing CACNB4 (calculated MW of 58.2kDa according to NP_000717.2 and 54.7kDa according to NP_001005747.1). Recommended concentration: 0.3-1ug/ml.
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 Western Blot (WB) of anti-CACNB4 antibody    (0.2ug/ml) staining of human bone marrow lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-CACNB4 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-CACNB4 antibody    HEK293 overexpressing CACNB4 (RC210440) and probed (mock transfection in first lane), tested by Origene.
anti-CACNB4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CACNB4. It may not necessarily be applicable to this product.
 NCBI GI #    54607068
 NCBI GeneID    785
 NCBI Accession #    NP_001005747.1 [Other Products]
 NCBI Related Accession #    NP_000717.2; NP_001005746.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001005747.2 [Other Products]
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 UniProt Secondary Accession #    O60515; Q6B000; Q96L40; A7BJ74; A8K1Y4; B4DG40 [Other Products]
 UniProt Related Accession #    O00305 [Other Products]
 Molecular Weight    51,331 Da
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 NCBI Official Full Name    voltage-dependent L-type calcium channel subunit beta-4 isoform a
 NCBI Official Synonym Full Names    calcium voltage-gated channel auxiliary subunit beta 4
 NCBI Official Symbol    CACNB4 [Similar Products]
 NCBI Official Synonym Symbols   
EA5; EJM; CAB4; EIG9; EJM4; EJM6; CACNLB4
[Similar Products]
 NCBI Protein Information    voltage-dependent L-type calcium channel subunit beta-4
 UniProt Protein Name    Voltage-dependent L-type calcium channel subunit beta-4
 UniProt Synonym Protein Names   
Calcium channel voltage-dependent subunit beta 4
 Protein Family    Voltage-dependent L-type calcium channel
 UniProt Gene Name    CACNB4 [Similar Products]
 UniProt Synonym Gene Names    CACNLB4; CAB4 [Similar Products]
 UniProt Entry Name    CACB4_HUMAN
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 NCBI Summary for CACNB4    This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for CACNB4    CACNB4: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB4 are the cause of susceptibility to epilepsy, idiopathic generalized type 9 (EIG9). A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Defects in CACNB4 are the cause of susceptibility to juvenile myoclonic epilepsy type 6 (EJM6). EJM6 is a subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Defects in CACNB4 are the cause of episodic ataxia type 5 (EA5). EA5 is a disorder characterized by episodes of vertigo and ataxia that last for several hours. Interictal examination show spontaneous downbeat and gaze-evoked nystagmus, mild dysarthria and truncal ataxia. Belongs to the calcium channel beta subunit family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium

Chromosomal Location of Human Ortholog: 2q22-q23

Cellular Component: cytosol; internal side of plasma membrane; plasma membrane; synapse; voltage-gated calcium channel complex

Molecular Function: calcium channel activity; high voltage-gated calcium channel activity; protein binding; protein kinase binding; voltage-gated calcium channel activity

Biological Process: action potential propagation; adult walking behavior; cAMP metabolic process; cellular calcium ion homeostasis; detection of light stimulus involved in visual perception; gamma-aminobutyric acid secretion; gamma-aminobutyric acid signaling pathway; membrane depolarization; muscle fiber development; neuromuscular junction development; Peyer's patch development; spleen development; synaptic transmission; synaptic transmission, glutamatergic; T cell receptor signaling pathway; thymus development; transport

Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 9; Episodic Ataxia, Type 5
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 Research Articles on CACNB4    1. The nuclear targeting properties of the truncated beta(4b(1-481)) subunit in tsA-201 cells, skeletal myotubes, and in hippocampal neurons, were investigated.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CACNB4 antibodyDiseases associated with anti-CACNB4 antibody
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cardiac Conduction Pathway antibodies  Cardiac Conduction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway antibodies  Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway Diagram
 Disease Name  Pubmed Publications
 Ataxia Antibodies  >14 publications with CACNB4 and Ataxia
 Epilepsy, Generalized Antibodies  >10 publications with CACNB4 and Epilepsy, Generalized
 Disease Models, Animal Antibodies  >7 publications with CACNB4 and Disease Models, Animal
 Myoclonic Epilepsy, Juvenile Antibodies  >7 publications with CACNB4 and Myoclonic Epilepsy, Juvenile
 Neurodegenerative Diseases Antibodies  >4 publications with CACNB4 and Neurodegenerative Diseases
 Atrophy Antibodies  >3 publications with CACNB4 and Atrophy
 Lung Diseases Antibodies  >2 publications with CACNB4 and Lung Diseases
 Inflammation Antibodies  >2 publications with CACNB4 and Inflammation
 Episodic Ataxia, Type 5 Antibodies  >2 publications with CACNB4 and Episodic Ataxia, Type 5
 Death Antibodies  >2 publications with CACNB4 and Death
Organs/Tissues associated with anti-CACNB4 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >29 publications with CACNB4 and Brain
 Muscle Antibodies  >7 publications with CACNB4 and Muscle
 Kidney Antibodies  >2 publications with CACNB4 and Kidney
 Thyroid Antibodies  >2 publications with CACNB4 and Thyroid
 Testis Antibodies  >1 publications with CACNB4 and Testis
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