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anti-Calcr antibody :: Rabbit CALCITONIN RECEPTOR Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS223231 anti-Calcr antibody
Unit / Price
0.01 mg  /  $175 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CALCITONIN RECEPTOR (Calcr), Polyclonal Antibody

 Also Known As   

RABBIT ANTI RAT CALCITONIN RECEPTOR

 Product Gene Name   

anti-Calcr antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P32214
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
 Immunogen    Synthetic peptide derived from a C-terminal sequence of rat calcitonin receptor.
Histology Positive Control Tissue
 Antiserum Preparation    Antisera to calcitonin receptor were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography on Protein A.
 Target Species    Rat
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch.
 Other Notes    Small volumes of anti-Calcr antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Calcr antibody

   Rabbit anti Rat Calcitonin Receptor antibody recognizes the calcitonin receptor in human, mouse and rat. The calcitonin receptor is a seven transmembrane domain cell surface protein which is coupled to G protein messenger systems. MBS221657 recognizes an epitope within the cytoplasmic domain that is common to both C1a and C1b rat isoforms. Calcitonin receptor is expressed in kidney, central and peripheral nervous systems and in osteoclasts. It is also expressed in a number of tissues during the development of the embryo and may be important in foetal morphogenesis.
 Applications Tested/Suitable for anti-Calcr antibody   

Immunohistology Frozen, ELISA (EIA), Immunofluorescence (IF), Immunohistology Paraffin*

 Application Notes for anti-Calcr antibody    Immunohistology - Frozen: Minimum Dilution: 1/10; Maximum Dilution: 1/50;
Immunohistology - Paraffin: Minimum Dilution: 1/10; Maximum Dilution: 1/50; Application Note: The use of 4% paraformaldehyde fixation, rather than formalin fixation is recommended.

A sensitive detection system is also recommended. e.g. A catalysed signal amplification system.
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NCBI/Uniprot data below describe general gene information for Calcr. It may not necessarily be applicable to this product.
 NCBI GI #    77404382
 NCBI GeneID    116506
 NCBI Accession #    NP_001029187.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001034015.1 [Other Products]
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 UniProt Primary Accession #    P32214 [Other Products]
 UniProt Secondary Accession #    P32213 [Other Products]
 UniProt Related Accession #    P32214 [Other Products]
 Molecular Weight    55,879 Da [Similar Products]
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 NCBI Official Full Name    calcitonin receptor isoform 1a
 NCBI Official Synonym Full Names    calcitonin receptor
 NCBI Official Symbol    Calcr [Similar Products]
 NCBI Protein Information    calcitonin receptor; C1A/C1B; CT-R
 UniProt Protein Name    Calcitonin receptor
 UniProt Synonym Protein Names   
C1A/C1B
 Protein Family    Calcitonin receptor
 UniProt Gene Name    Calcr [Similar Products]
 UniProt Synonym Gene Names    CT-R [Similar Products]
 UniProt Entry Name    CALCR_RAT
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 NCBI Summary for Calcr    receptor for calcitonin; acts via adenylate cyclase signaling [RGD, Feb 2006]
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 UniProt Comments for Calcr    CALCR: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. Belongs to the G-protein coupled receptor 2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral; Receptor, GPCR

Cellular Component: neuron projection; cell soma; axon; plasma membrane; integral to membrane; acrosome; cytosol; cilium

Molecular Function: calcitonin binding; receptor activity; protein transporter activity; calcitonin receptor activity

Biological Process: regulation of bone resorption; response to glucocorticoid stimulus; adenylate cyclase activation; osteoclast differentiation; regulation of mRNA stability; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; protein transport; elevation of cytosolic calcium ion concentration; phospholipase C activation; receptor internalization; positive regulation of cAMP biosynthetic process; negative regulation of ossification; positive regulation of adenylate cyclase activity
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 Research Articles on Calcr    1. In conclusion, oral KBP-042 is a novel DACRA, which exerts antiobesity and antidiabetic efficacy by dual modulation of insulin sensitivity and directly decelerating stress on the pancreatic alpha- and beta-cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Calcr antibodyDiseases associated with anti-Calcr antibody
 Products by Pathway  Pathway Diagram
 Calcitonin-like Ligand Receptors Pathway antibodies  Calcitonin-like Ligand Receptors Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Disease Name  Pubmed Publications
 Osteoporosis Antibodies  >10 publications with Calcr and Osteoporosis
 Lung Diseases Antibodies  >4 publications with Calcr and Lung Diseases
 Inflammation Antibodies  >3 publications with Calcr and Inflammation
 Fibrosis Antibodies  >3 publications with Calcr and Fibrosis
 Necrosis Antibodies  >2 publications with Calcr and Necrosis
 Death Antibodies  >2 publications with Calcr and Death
 Nervous System Diseases Antibodies  >1 publications with Calcr and Nervous System Diseases
 Insulin Resistance Antibodies  >1 publications with Calcr and Insulin Resistance
 Kidney Diseases Antibodies  >1 publications with Calcr and Kidney Diseases
 Memory Disorders Antibodies  >1 publications with Calcr and Memory Disorders
Organs/Tissues associated with anti-Calcr antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with Calcr and Brain
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