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anti-CAMK2D antibody :: Rabbit CAMK2D Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS125250
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CAMK2D, Polyclonal Antibody

 Also Known As   

CAMK2D Polyclonal Antibody

 Product Synonym Names    CAMKD; DKFZp686G23119; DKFZp686I2288; MGC44911
 Product Gene Name   

anti-CAMK2D antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607708
 3D Structure    ModBase 3D Structure for Q13557
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human CAMK2D
 Calculated Molecular Weight    56kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-CAMK2D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CAMK2D antibody

   The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]
 Product Categories/Family for anti-CAMK2D antibody    Polyclonal
 Applications Tested/Suitable for anti-CAMK2D antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-CAMK2D antibody    WB: 1:500 - 1:1000
IHC: 1:50 - 1:100
IF: 1:20 - 1:50
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 Western Blot (WB) of anti-CAMK2D antibody    Western blot analysis of extracts of HeLa cells tissue, using CAMK2D antibody.
anti-CAMK2D antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CAMK2D. It may not necessarily be applicable to this product.
 NCBI GI #    116242602
 NCBI GeneID    817
 NCBI Accession #    Q13557.3 [Other Products]
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 UniProt Primary Accession #    Q13557 [Other Products]
 UniProt Secondary Accession #    Q52PK4; Q59G21; Q8N553; Q9UGH6; Q9UQE9; A8MVS8 [Other Products]
 UniProt Related Accession #    Q13557 [Other Products]
 Molecular Weight    499
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 NCBI Official Full Name    Calcium/calmodulin-dependent protein kinase type II subunit delta
 NCBI Official Synonym Full Names    calcium/calmodulin-dependent protein kinase II delta
 NCBI Official Symbol    CAMK2D [Similar Products]
 NCBI Official Synonym Symbols   
CAMKD
[Similar Products]
 NCBI Protein Information    calcium/calmodulin-dependent protein kinase type II subunit delta; CaMK-II delta subunit; caMK-II subunit delta; CaM-kinase II delta chain; CaM kinase II delta subunit; caM kinase II subunit delta; calcium/calmodulin-dependent protein kinase type II delta chain; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta
 UniProt Protein Name    Calcium/calmodulin-dependent protein kinase type II subunit delta
 Protein Family    Calcium/calmodulin-dependent protein kinase
 UniProt Gene Name    CAMK2D [Similar Products]
 UniProt Synonym Gene Names    CAMKD; CaM kinase II subunit delta; CaMK-II subunit delta [Similar Products]
 UniProt Entry Name    KCC2D_HUMAN
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 NCBI Summary for CAMK2D    The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]
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 UniProt Comments for CAMK2D    CAMK2D: a protein kinase of the calcium/calmodulin-dependent protein kinase (CAMK) group that interacts with the sarcoplasmic reticulum membrane in cardiac and skeletal muscle. Regulates Ca2+ homeostatis and excitation-contraction coupling (ECC) in heart. Calmodulin binding induces conformational changes that relieve autoinhibition, permitting autophosphorylation at T287, rendering the kinase constitutively active and independent of Ca2+-binding. Targets ion channels, transporters and accessory proteins involved in Ca2+ influx into the myocyte, Ca2+ release from the sarcoplasmic reticulum (SR), SR Ca2+ uptake and Na+ and K+ channel transport. Also targets transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca2+ release via direct phosphorylation of RYR2 Ca2+ channel on S2808. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca2+ influx to myocytes by binding and phosphorylating the L-type Ca2+ channel subunit beta-2 CACNB2. In addition to Ca2+ channels, can target and regulate the cardiac sarcolemmal Na+ channel SCN5A and the K+ channel Kv4.3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLB), an endogenous inhibitor of SERCA2A, contributing to the enhancement of SR Ca2+ uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca2+ transport through phosphorylation of PLB and TRDN, a ryanodine receptor-coupling factor. CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with RRAD and CACNB2. Ten isoforms of the human protein are produced by alternative splicing. Isoform Delta3, isoform Delta2, isoform Delta8 and isoform Delta9 are expressed in cardiac muscle. Isoform Delta11 is expressed in skeletal muscle. Activity is induced in skeletal muscle during exercise. The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.

Protein type: EC 2.7.11.17; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMK2 family

Chromosomal Location of Human Ortholog: 4q26

Cellular Component: nucleoplasm; sarcoplasmic reticulum membrane; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nucleus; cytosol; sarcolemma

Molecular Function: calmodulin binding; sodium channel inhibitor activity; protein serine/threonine kinase activity; protein binding; protein homodimerization activity; calmodulin-dependent protein kinase activity; titin binding; nitric-oxide synthase binding; ATP binding

Biological Process: positive regulation of smooth muscle cell proliferation; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; peptidyl-threonine phosphorylation; positive regulation of smooth muscle cell migration; protein amino acid phosphorylation; cellular potassium ion homeostasis; regulation of heart contraction; protein oligomerization; regulation of transcription from RNA polymerase II promoter; positive regulation of Rac protein signal transduction; synaptic transmission; endoplasmic reticulum calcium ion homeostasis; peptidyl-serine phosphorylation; regulation of G2/M transition of mitotic cell cycle; response to hypoxia; regulation of cell growth; regulation of the force of heart contraction
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 Research Articles on CAMK2D    1. CaMKIID specifically phosphorylates Thr-457 on CEACAM1-SF, which in turn regulates the process of lumen formation via apoptosis of the central acinar cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CAMK2D antibodyPathways associated with anti-CAMK2D antibody
 Reference Product  PubMed Publications
 CAMK2B antibody  >2 publications with CAMK2D and CAMK2B
 CALM2 antibody  >1 publications with CAMK2D and CALM2
 Products by Pathway  Pathway Diagram
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 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
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 CREB Phosphorylation Through The Activation Of CaMKII Pathway antibodies  CREB Phosphorylation Through The Activation Of CaMKII Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
Diseases associated with anti-CAMK2D antibodyOrgans/Tissues associated with anti-CAMK2D antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >16 publications with CAMK2D and Cardiovascular Diseases
 Heart Diseases Antibodies  >14 publications with CAMK2D and Heart Diseases
 Hypertrophy Antibodies  >7 publications with CAMK2D and Hypertrophy
 Disease Models, Animal Antibodies  >4 publications with CAMK2D and Disease Models, Animal
 Nervous System Diseases Antibodies  >3 publications with CAMK2D and Nervous System Diseases
 Arrhythmias, Cardiac Antibodies  >3 publications with CAMK2D and Arrhythmias, Cardiac
 Cardiomyopathies Antibodies  >3 publications with CAMK2D and Cardiomyopathies
 Seizures Antibodies  >2 publications with CAMK2D and Seizures
 Brain Diseases Antibodies  >2 publications with CAMK2D and Brain Diseases
 Myocardial Ischemia Antibodies  >2 publications with CAMK2D and Myocardial Ischemia
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >22 publications with CAMK2D and Muscle
 Heart Antibodies  >20 publications with CAMK2D and Heart
 Brain Antibodies  >11 publications with CAMK2D and Brain
 Blood Antibodies  >5 publications with CAMK2D and Blood
 Pancreas Antibodies  >3 publications with CAMK2D and Pancreas
 Connective Tissue Antibodies  >2 publications with CAMK2D and Connective Tissue
 Embryonic Tissue Antibodies  >2 publications with CAMK2D and Embryonic Tissue
 Bone Antibodies  >1 publications with CAMK2D and Bone
 Kidney Antibodies  >1 publications with CAMK2D and Kidney
 Lung Antibodies  >1 publications with CAMK2D and Lung
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