P04632.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Calpain small subunit 1
NCBI Official Synonym Full Names
calpain, small subunit 1
NCBI Official Synonym Symbols
CANP; CDPS; CSS1; CANPS; CAPN4; CALPAIN4 [Similar Products]
NCBI Protein Information
calpain small subunit 1; CANP small subunit; calpain regulatory subunit; calpain, small polypeptide; calpain 4, small subunit (30K); calcium-dependent protease, small subunit; calcium-dependent protease small subunit 1; calcium-activated neutral proteinase small subunit
UniProt Protein Name
Calpain small subunit 1
UniProt Synonym Protein Names
Calcium-activated neutral proteinase small subunit; CANP small subunit; Calcium-dependent protease small subunit; CDPS; Calcium-dependent protease small subunit 1; Calpain regulatory subunit
UniProt Synonym Gene Names
UniProt Entry Name
CPNS1_HUMAN
NCBI Summary for CAPNS1
This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
UniProt Comments for CAPNS1
CAPNS1: Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Protein type: Protease; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19q13.12
Cellular Component: membrane; cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding
Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; positive regulation of cell proliferation; proteolysis
Research Articles on CAPNS1
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Products associated with anti-CAPNS1 antibody
Pathways associated with anti-CAPNS1 antibody
Diseases associated with anti-CAPNS1 antibody
Organs/Tissues associated with anti-CAPNS1 antibody
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