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anti-CAPRIN2 antibody :: Rabbit CAPRIN2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2516464
Unit / Price
0.06 mL  /  $195 +1 FREE 8GB USB
0.12 mL  /  $270 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CAPRIN2, Polyclonal Antibody

★Popular Item★
 Also Known As   

CAPRIN2 Antibody

 Product Synonym Names    C1QDC1, caprin 2, caprin family member 2, CAPRIN2, EEG 1, EEG1, KIAA1873, Protein EEG1, RNA granule protein 140, RNG140
 Product Gene Name   

anti-CAPRIN2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2516464 Technical Datasheet    Technical Datasheet PDF
 OMIM    610375
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
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 Immunogen    Fusion protein of CAPRIN2
 Buffer    PBS with 0.02% sodium azide and 50% glycerol pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-107473 / sc-107474
 Calculated MW    1127aa,126 kDa
 Observed MW    150 kDa
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CAPRIN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CAPRIN2 antibody

   Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Faciliates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112).
 Applications Tested/Suitable for anti-CAPRIN2 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-CAPRIN2 antibody    WB 1:200-1:1000, IF 1:20-1:200
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 Western Blot of anti-CAPRIN2 antibody    SH-SY5Y cells were subjected to SDS-PAGE followed by western blot with CAPRIN2 Polyclonal Antibody at dilution of 1:300
anti-CAPRIN2 antibody Western Blot (WB) image
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 Immunofluorescent of anti-CAPRIN2 antibody    Immunofluorescent analysis of HepG2 cells using CAPRIN2 Polyclonal Antibody at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-CAPRIN2 antibody Immunofluorescent image
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NCBI/Uniprot data below describe general gene information for CAPRIN2. It may not necessarily be applicable to this product.
 NCBI GI #    332205983
 NCBI GeneID    65981
 NCBI Accession #    NP_001193785.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001206856.2 [Other Products]
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 UniProt Secondary Accession #    Q149P6; Q149P7; Q6IMN5; Q7Z371; Q8TE70; Q8TE71; Q96RN6; Q9H667; Q9HAL4; E4NKG2 [Other Products]
 UniProt Related Accession #    Q6IMN6 [Other Products]
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 NCBI Official Full Name    caprin-2 isoform 4
 NCBI Official Synonym Full Names    caprin family member 2
 NCBI Official Symbol    CAPRIN2 [Similar Products]
 NCBI Official Synonym Symbols   
EEG1; EEG-1; C1QDC1; RNG140
[Similar Products]
 NCBI Protein Information    caprin-2; C1q domain-containing protein 1; CAPRIN2; RNA granule protein 140; cytoplasmic activation/proliferation-associated protein 2; gastric cancer multidrug resistance-associated protein
 UniProt Protein Name    Caprin-2
 UniProt Synonym Protein Names   
C1q domain-containing protein 1; Cytoplasmic activation/proliferation-associated protein 2; Gastric cancer multidrug resistance-associated protein; Protein EEG-1; RNA granule protein 140
 Protein Family    Caprin
 UniProt Gene Name    CAPRIN2 [Similar Products]
 UniProt Entry Name    CAPR2_HUMAN
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 NCBI Summary for CAPRIN2    The protein encoded by this gene may be involved in the transitioning of erythroblasts from a highly proliferative state to a terminal phase of differentiation. High level expression of the encoded protein can lead to apoptosis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
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 UniProt Comments for CAPRIN2    C1QDC1: May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis. Belongs to the caprin family. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 12p11

Cellular Component: nucleoplasm; centrosome; mitochondrion; cytoplasm; nucleus; receptor complex

Molecular Function: protein binding; RNA binding; receptor binding

Biological Process: positive regulation of protein binding; negative regulation of translation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite morphogenesis; negative regulation of cell growth; positive regulation of peptidyl-serine phosphorylation
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 Research Articles on CAPRIN2    1. Caprin-2 promotes activation of the canonical Wnt signaling pathway by regulating LRP5/6 phosphorylation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-CAPRIN2 antibodyOrgans/Tissues associated with anti-CAPRIN2 antibody
 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >1 publications with CAPRIN2 and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >1 publications with CAPRIN2 and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with CAPRIN2 and Liver Diseases
 Necrosis Antibodies  >1 publications with CAPRIN2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with CAPRIN2 and Blood
 Skin Antibodies  >1 publications with CAPRIN2 and Skin
 Spleen Antibodies  >1 publications with CAPRIN2 and Spleen
 Muscle Antibodies  >1 publications with CAPRIN2 and Muscle
 Kidney Antibodies  >1 publications with CAPRIN2 and Kidney
 Liver Antibodies  >1 publications with CAPRIN2 and Liver
 Eye Antibodies  >1 publications with CAPRIN2 and Eye
 Brain Antibodies  >1 publications with CAPRIN2 and Brain
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