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anti-CADPS antibody :: Rabbit CAPS1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150862
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CAPS1 (CADPS), Polyclonal Antibody

★Popular Item★
 Also Known As   

CAPS1 Antibody

 Product Synonym Names    CAPS1; CAPS; CAPS1; CADPS1; CAPS; KIAA1121; Calcium-dependent secretion activator 1; Calcium-dependent activator protein for secretion 1; CAPS-1; Ca++-dependent secretion activator
 Product Gene Name   

anti-CADPS antibody

[Similar Products]
 Antibody/Peptide Pairs    CAPS1 peptide (MBS151794) is used for blocking the activity of CAPS1 antibody (MBS150862)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604667
 3D Structure    ModBase 3D Structure for Q9ULU8
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Numerous isoforms of CAPS1 are known to exist; the lower molecular weight bands seen in the immunoblot image are likely to be these isoforms. This CAPS1 antibody is predicted to be specific to CAPS1 and not recognize CAPS2.
 Purity/Purification    CAPS1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    CAPS1 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of the human CAPS1.
 Buffer    CAPS1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    CAPS1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-CADPS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CADPS antibody

   CAPS1 Antibody: CAPS1 and its related protein CAPS2 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles; CAPS-deficienct neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. CAPS1 acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4, 5-bisphosphate and is thought to be a specific regulator of large dense-core vesicle fusion.
 Applications Tested/Suitable for anti-CADPS antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-CADPS antibody    CAPS1 antibody can be used for detection of CAPS1 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-CADPS antibody    Western blot analysis of CAPS1 in rat brain tissue lysate with CAPS1 antibody at (A) 0.5 and (B) 1 μg/mL.
anti-CADPS antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CADPS antibody    Immunohistochemistry of CAPS1 in human brain with CAPS1 antibody at 5 μg/mL.
anti-CADPS antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-CADPS antibody    Immunofluorescence of CAPS1 in human brain tissue with CAPS1 antibody at 20 μg/mL.
anti-CADPS antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for CADPS. It may not necessarily be applicable to this product.
 NCBI GI #    34452713
 NCBI GeneID    8618
 NCBI Accession #    NP_899631 [Other Products]
 NCBI GenBank Nucleotide #    NM_183394.2 [Other Products]
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 UniProt Primary Accession #    Q9ULU8 [Other Products]
 UniProt Secondary Accession #    Q13339; Q6GQQ6; Q8N2Z5; Q8N3M7; Q8NFR0; Q96BC2; A6NF60 [Other Products]
 UniProt Related Accession #    Q9ULU8 [Other Products]
 Molecular Weight    50,236 Da
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 NCBI Official Full Name    calcium-dependent secretion activator 1 isoform 2
 NCBI Official Synonym Full Names    Ca++-dependent secretion activator
 NCBI Official Symbol    CADPS [Similar Products]
 NCBI Official Synonym Symbols   
CAPS; CAPS1; CADPS1
[Similar Products]
 NCBI Protein Information    calcium-dependent secretion activator 1; CAPS-1; Ca2+-dependent secretion activator; Ca2+-regulated cytoskeletal protein; Ca2+-dependent activator protein for secretion; calcium-dependent activator protein for secretion 1
 UniProt Protein Name    Calcium-dependent secretion activator 1
 UniProt Synonym Protein Names   
Calcium-dependent activator protein for secretion 1; CAPS-1
 Protein Family    Calcium-dependent secretion activator
 UniProt Gene Name    CADPS [Similar Products]
 UniProt Synonym Gene Names    CAPS; CAPS1; KIAA1121; CAPS-1 [Similar Products]
 UniProt Entry Name    CAPS1_HUMAN
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 NCBI Summary for CADPS    This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]
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 UniProt Comments for CADPS    CADPS: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 3p14.2

Cellular Component: cytoplasmic vesicle membrane; synapse; cytosol; cell junction

Molecular Function: protein binding; metal ion binding; lipid binding; protein kinase binding

Biological Process: catecholamine secretion; protein transport; exocytosis; vesicle organization and biogenesis; synaptic vesicle priming
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 Research Articles on CADPS    1. the preferential binding of CAPS1 to open syntaxin-1 can contribute to the stabilization of the open state of syntaxin-1 during its transition from "closed" state to the SNARE complex formation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CADPS antibodyDiseases associated with anti-CADPS antibody
 Reference Product  PubMed Publications
 CAPS2 antibody  >11 publications with CADPS and CAPS2
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >2 publications with CADPS and Brain Diseases
 Child Development Disorders, Pervasive Antibodies  >1 publications with CADPS and Child Development Disorders, Pervasive
 Nervous System Diseases Antibodies  >1 publications with CADPS and Nervous System Diseases
 Embryo Loss Antibodies  >1 publications with CADPS and Embryo Loss
 Hypertension Antibodies  >1 publications with CADPS and Hypertension
 Weight Loss Antibodies  >1 publications with CADPS and Weight Loss
 Inflammation Antibodies  >1 publications with CADPS and Inflammation
Organs/Tissues associated with anti-CADPS antibody
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >18 publications with CADPS and Nerve
 Brain Antibodies  >13 publications with CADPS and Brain
 Embryonic Tissue Antibodies  >4 publications with CADPS and Embryonic Tissue
 Adrenal Gland Antibodies  >4 publications with CADPS and Adrenal Gland
 Pituitary Gland Antibodies  >3 publications with CADPS and Pituitary Gland
 Pancreas Antibodies  >2 publications with CADPS and Pancreas
 Eye Antibodies  >2 publications with CADPS and Eye
 Kidney Antibodies  >1 publications with CADPS and Kidney
 Testis Antibodies  >1 publications with CADPS and Testis
 Ovary Antibodies  >1 publications with CADPS and Ovary
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