NP_899631
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,236 Da
NCBI Official Full Name
calcium-dependent secretion activator 1 isoform 2
NCBI Official Synonym Full Names
Ca++-dependent secretion activator
NCBI Protein Information
calcium-dependent secretion activator 1; CAPS-1; Ca2+-dependent secretion activator; Ca2+-regulated cytoskeletal protein; Ca2+-dependent activator protein for secretion; calcium-dependent activator protein for secretion 1
UniProt Protein Name
Calcium-dependent secretion activator 1
UniProt Synonym Protein Names
Calcium-dependent activator protein for secretion 1; CAPS-1
UniProt Synonym Gene Names
UniProt Entry Name
CAPS1_HUMAN
NCBI Summary for CADPS
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]
UniProt Comments for CADPS
CADPS: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 3p14.2
Cellular Component: cytoplasmic vesicle membrane; synapse; cytosol; cell junction
Molecular Function: protein binding; metal ion binding; lipid binding; protein kinase binding
Biological Process: catecholamine secretion; protein transport; exocytosis; vesicle organization and biogenesis; synaptic vesicle priming
Research Articles on CADPS
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Products associated with anti-CADPS antibody
Diseases associated with anti-CADPS antibody
Organs/Tissues associated with anti-CADPS antibody
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