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anti-CARD14 antibody :: Rabbit anti-Human CARD14 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2517739
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CARD14, Polyclonal Antibody

★Popular Item★
 Also Known As   

CARD14 Polyclonal Antibody

 Product Synonym Names    PRP; PSS1; BIMP2; CARMA2; PSORS2
 Product Gene Name   

anti-CARD14 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    173200
 3D Structure    ModBase 3D Structure for BC018142
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity purification
 Concentration    1.3mg/mL (lot specific)
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CARD14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CARD14 antibody

   Background: This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants.
 Product Categories/Family for anti-CARD14 antibody    Cell biology
 Applications Tested/Suitable for anti-CARD14 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CARD14 antibody    WB: 1:200-1:1000
IHC: 1:25-1:100
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 Western Blot (WB) of anti-CARD14 antibody    Western Blot analysis of Human fetal brain tissue using CARD14 Polyclonal Antibody at dilution of 1:650
anti-CARD14 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CARD14 antibody    Immunohistochemistry of paraffin-embedded Human liver cancer using CARD14 Polyclonal Antibody at dilution of 1:30
anti-CARD14 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CARD14 antibody    Immunohistochemistry of paraffin-embedded Human thyroid cancer using CARD14 Polyclonal Antibody at dilution of 1:30
anti-CARD14 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CARD14. It may not necessarily be applicable to this product.
 NCBI GI #    384229040
 NCBI GeneID    79092
 NCBI Accession #    NP_001244899.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001257970.1 [Other Products]
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 UniProt Primary Accession #    BC018142 [Other Products]
 UniProt Secondary Accession #    Q9BVB5; B8QQJ3 [Other Products]
 UniProt Related Accession #    Q9BXL6 [Other Products]
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 NCBI Official Full Name    caspase recruitment domain-containing protein 14 isoform 3
 NCBI Official Synonym Full Names    caspase recruitment domain family, member 14
 NCBI Official Symbol    CARD14 [Similar Products]
 NCBI Official Synonym Symbols   
PRP; PSS1; BIMP2; CARMA2; PSORS2
[Similar Products]
 NCBI Protein Information    caspase recruitment domain-containing protein 14; CARD-containing MAGUK protein 2; bcl10-interacting maguk protein 2
 UniProt Protein Name    Caspase recruitment domain-containing protein 14
 UniProt Synonym Protein Names   
CARD-containing MAGUK protein 2; Carma 2
 Protein Family    Caspase recruitment domain-containing protein
 UniProt Gene Name    CARD14 [Similar Products]
 UniProt Synonym Gene Names    CARMA2; Carma 2 [Similar Products]
 UniProt Entry Name    CAR14_HUMAN
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 NCBI Summary for CARD14    This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
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 UniProt Comments for CARD14    CARD14: a protein containing a caspase recruitment domain (CARD) that functions as an activator of BCL10 and NF-kappaB signaling. CARD is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in signaling through highly specific protein-protein homophilic interactions. CARD proteins function as scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. The CARD domain of CARD14 associates specifically with the CARD domains of CARD10 and BCL10, a signaling protein that activates NF-kB through the IkappaB kinase complex in response to upstream stimuli. When expressed in cells, CARD14 activates NF-kappaB and induces the phosphorylation of BCL10. A subgroup of primary lymphomas of the central nervous system have higher levels of CARD14 expression.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: cytoplasm; plasma membrane

Molecular Function: CARD domain binding

Biological Process: tumor necrosis factor-mediated signaling pathway; apoptosis; activation of NF-kappaB-inducing kinase; positive regulation of protein amino acid phosphorylation; negative regulation of apoptosis; activation of NF-kappaB transcription factor

Disease: Psoriasis 2; Pityriasis Rubra Pilaris
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 Research Articles on CARD14    1. Owing to the relatively small number of cases analysed in this study, we cannot rule out the possibility that CARD14 mutations may be an exceptional cause of sporadic pityriasis rubra pilaris, as previously found in sporadic psoriasis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CARD14 antibodyDiseases associated with anti-CARD14 antibody
 Reference Product  PubMed Publications
 BCL10 antibody  >6 publications with CARD14 and BCL10
 MALT1 antibody  >2 publications with CARD14 and MALT1
 RIPK2 antibody  >1 publications with CARD14 and RIPK2
 Disease Name  Pubmed Publications
 Psoriasis Antibodies  >20 publications with CARD14 and Psoriasis
 Inflammation Antibodies  >8 publications with CARD14 and Inflammation
 Necrosis Antibodies  >4 publications with CARD14 and Necrosis
 Arthritis, Experimental Antibodies  >1 publications with CARD14 and Arthritis, Experimental
 Granuloma Antibodies  >1 publications with CARD14 and Granuloma
 Kidney Diseases Antibodies  >1 publications with CARD14 and Kidney Diseases
 Hypertension Antibodies  >1 publications with CARD14 and Hypertension
 Liver Diseases Antibodies  >1 publications with CARD14 and Liver Diseases
 Hyperplasia Antibodies  >1 publications with CARD14 and Hyperplasia
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