AAH44774
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
115,301 Da
NCBI Official Full Name
Nod2 protein, partial
NCBI Official Synonym Full Names
nucleotide-binding oligomerization domain containing 2
NCBI Official Synonym Symbols
CD; ACUG; BLAU; IBD1; Nlrc2; Card15; F830032C23Rik [Similar Products]
NCBI Protein Information
nucleotide-binding oligomerization domain-containing protein 2
UniProt Protein Name
Nucleotide-binding oligomerization domain-containing protein 2
UniProt Synonym Protein Names
Caspase recruitment domain-containing protein 15
UniProt Synonym Gene Names
UniProt Comments for CARD15
Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response (PubMed:22607974). Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1. Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon.
Research Articles on CARD15
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Products associated with anti-CARD15 antibody
Pathways associated with anti-CARD15 antibody
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