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anti-CARKL antibody :: Rabbit CARKL Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9604927
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CARKL, Polyclonal Antibody

★Popular Item★
 Also Known As   

CARKL Antibody

 Product Synonym Names    Carbohydrate kinase like; Carbohydrate kinase like protein; Carbohydrate kinase-like protein; CARKL; Sedoheptulokinase; SHK; Shpk; SHPK_HUMAN
 Product Gene Name   

anti-CARKL antibody

[Similar Products]
 Product Synonym Gene Name    SHPK [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9UHJ6
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    CARKL antibody detects endogenous levels of total CARKL
 Purity/Purification    The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
 Form/Format    Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    A synthesized peptide
 Subcellular Location    Cytoplasm.
 Tissue Specificity    Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain.
 Conjugation    Unconjugated
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 Preparation and Storage    Store at -20 degree C. Stable for 12 months from date of receipt.
 Other Notes    Small volumes of anti-CARKL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CARKL antibody

   Function: Acts as a modulator of macrophage activation through control of glucose metabolism.
Similarity: Belongs to the FGGY kinase family.
 Applications Tested/Suitable for anti-CARKL antibody   

Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)

 Application Notes for anti-CARKL antibody    WB: 1:500-1:1000
IHC: 1:50-1:200
IF/ICC: 1:100-1:500
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 Immunofluorescence (IF) of anti-CARKL antibody    MBS9604927 staining Hela cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
anti-CARKL antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-CARKL antibody    Western blot analysis of extracts from Jurkat cells, using CARKL antibody.The lane on the left is treated with the antigen-specific peptide.
anti-CARKL antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CARKL antibody    MBS9604927 at 1/100 staining Human brain cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
anti-CARKL antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CARKL. It may not necessarily be applicable to this product.
 NCBI GI #    74315356
 NCBI GeneID    23729
 NCBI Accession #    NP_037408.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_013276.2 [Other Products]
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 UniProt Primary Accession #    Q9UHJ6 [Other Products]
 UniProt Secondary Accession #    Q8WUH3; B2R640 [Other Products]
 UniProt Related Accession #    Q9UHJ6 [Other Products]
 Molecular Weight    Observed: 55 kD
Predicted: 52 kDa
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 NCBI Official Full Name    sedoheptulokinase
 NCBI Official Synonym Full Names    sedoheptulokinase
 NCBI Official Symbol    SHPK [Similar Products]
 NCBI Official Synonym Symbols   
SHK; CARKL
[Similar Products]
 NCBI Protein Information    sedoheptulokinase
 UniProt Protein Name    Sedoheptulokinase
 UniProt Synonym Protein Names   
Carbohydrate kinase-like protein
 UniProt Gene Name    SHPK [Similar Products]
 UniProt Synonym Gene Names    CARKL; SHK [Similar Products]
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 NCBI Summary for CARKL    The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CARKL    Acts as a modulator of macrophage activation through control of glucose metabolism.
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 Research Articles on CARKL    1. CARKL-dependent metabolic reprogramming is required for proper M1- and M2-like macrophage polarization
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-CARKL antibodyOrgans/Tissues associated with anti-CARKL antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1 publications with CARKL and Necrosis
 Inflammation Antibodies  >1 publications with CARKL and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with CARKL and Blood
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