NP_001014437.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
94,638 Da
NCBI Official Full Name
cysteine--tRNA ligase, cytoplasmic isoform c
NCBI Official Synonym Full Names
cysteinyl-tRNA synthetase
NCBI Protein Information
cysteine--tRNA ligase, cytoplasmic
UniProt Protein Name
Cysteine--tRNA ligase, cytoplasmic
UniProt Synonym Protein Names
Cysteinyl-tRNA synthetase; CysRS
UniProt Synonym Gene Names
UniProt Entry Name
SYCC_HUMAN
NCBI Summary for CARS
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]
UniProt Comments for CARS
CARS: a class 1 aminoacyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. Two alternatively spliced isoforms are described.
Protein type: Translation; Oncoprotein; Ligase; EC 6.1.1.16
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: cytoplasm; cytosol
Molecular Function: ATP binding; cysteine-tRNA ligase activity; metal ion binding; protein binding; protein homodimerization activity; tRNA binding
Biological Process: cysteinyl-tRNA aminoacylation; gene expression; tRNA aminoacylation for protein translation
Research Articles on CARS
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Products associated with anti-CARS antibody
Pathways associated with anti-CARS antibody
Diseases associated with anti-CARS antibody
Organs/Tissues associated with anti-CARS antibody
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