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anti-CASC5 antibody :: Rabbit anti-Human CASC5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS612441 anti-CASC5 antibody
Unit / Price
0.1 mg  /  $700 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CASC5, Polyclonal Antibody

 Also Known As   

CASC5 (CASC-5, Cancer Susceptibility Candidate 5, D40, KIAA1570)

 Product Synonym Names    Anti -CASC5 (CASC-5, Cancer Susceptibility Candidate 5, D40, KIAA1570)
 Product Gene Name   

anti-CASC5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 15; NC_000015.9 (40886447..40954881). Location: 15q14
 3D Structure    ModBase 3D Structure for Q05C46
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Species Crossreactivity: Human.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Tris-citrate/phosphate [pH7-8]
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 Immunogen    Synthetic peptide corresponding to amino acid residues between residue 250 and 300 of human Cancer Susceptibility Candidate 5 using the numbering given in entry NP_733468.2 (GeneID 57082).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-CASC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CASC5 antibody    Antibodies; Abs to Cell Markers
 Applications Tested/Suitable for anti-CASC5 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-CASC5 antibody    Suitable for use in ELISA, Western Blotting, Immunoprecipitation.
Dilution: Western Blotting: 1:1000-1:2000
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NCBI/Uniprot data below describe general gene information for CASC5. It may not necessarily be applicable to this product.
 NCBI GI #    116283489
 NCBI GeneID    57082
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 UniProt Primary Accession #    Q05C46 [Other Products]
 UniProt Related Accession #    Q05C46; Q8NG31 [Other Products]
 Molecular Weight    47,881 Da [Similar Products]
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 NCBI Official Full Name    CASC5 protein
 NCBI Official Synonym Full Names    cancer susceptibility candidate 5
 NCBI Official Symbol    CASC5 [Similar Products]
 NCBI Official Synonym Symbols   
D40; CT29; KNL1; hKNL-1; AF15Q14; hSpc105; KIAA1570
[Similar Products]
 NCBI Protein Information    protein CASC5; OTTHUMP00000233260; OTTHUMP00000233262; OTTHUMP00000233428; cancer/testis antigen 29; kinetochore null 1 homolog; kinetochore-null protein 1; bub-linking kinetochore protein; blinkin, bub-linking kinetochore protein; ALL1-fused gene from chromosome 15q14 protein; cancer susceptibility candidate gene 5 protein
 UniProt Protein Name    CASC5 protein
 Protein Family    Protein
 UniProt Gene Name    CASC5 [Similar Products]
 UniProt Entry Name    Q05C46_HUMAN
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 NCBI Summary for CASC5    The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013]
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 UniProt Comments for CASC5    CASC5 iso6: Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. A chromosomal aberration involving CASC5 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with MLL/HRX. May give rise to a MLL-CASC5 fusion protein. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: nucleoplasm; cytoplasm; acrosome; nucleus; cytosol

Molecular Function: protein binding

Biological Process: acrosome formation; mitosis; nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; cell division; mitotic cell cycle; attachment of spindle microtubules to kinetochore
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 Research Articles on CASC5    1. Expression levels of D40 mRNA and proteins decrease according to the degree of spermatogenesis impairment in male infertile patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CASC5 antibodyPathways associated with anti-CASC5 antibody
 Reference Product  PubMed Publications
 MIS12 antibody  >4 publications with CASC5 and MIS12
 DSN1 antibody  >1 publications with CASC5 and DSN1
 Products by Pathway  Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway antibodies  Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic M-M/G1 Phases Pathway antibodies  Mitotic M-M/G1 Phases Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 Nucleosome Assembly Pathway antibodies  Nucleosome Assembly Pathway Diagram
Diseases associated with anti-CASC5 antibodyOrgans/Tissues associated with anti-CASC5 antibody
 Disease Name  Pubmed Publications
 Leukemia Antibodies  >3 publications with CASC5 and Leukemia
 Leukemia, T-Cell Antibodies  >1 publications with CASC5 and Leukemia, T-Cell
 Neuroectodermal Tumors Antibodies  >1 publications with CASC5 and Neuroectodermal Tumors
 Colorectal Neoplasms Antibodies  >1 publications with CASC5 and Colorectal Neoplasms
 Leukemia, Myeloid, Acute Antibodies  >1 publications with CASC5 and Leukemia, Myeloid, Acute
 Lymphoma Antibodies  >1 publications with CASC5 and Lymphoma
 Leukemia, Lymphoid Antibodies  >1 publications with CASC5 and Leukemia, Lymphoid
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >4 publications with CASC5 and Testis
 Blood Antibodies  >1 publications with CASC5 and Blood
 Intestine Antibodies  >1 publications with CASC5 and Intestine
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