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anti-CBLC antibody :: Rabbit anti-Human CBL-C Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS627246 anti-CBLC antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CBL-C (CBLC), Polyclonal Antibody

 Also Known As   

CBL-C, NT (Signal Transduction Protein CBL-C, SH3-binding Protein CBL-C, SH3-binding Protein CBL-3, CBL3, RING Finger Protein 57, RNF57)

 Product Synonym Names    Anti -CBL-C, NT (Signal Transduction Protein CBL-C, SH3-binding Protein CBL-C, SH3-binding Protein CBL-3, CBL3, RING Finger Protein 57, RNF57)
 Product Gene Name   

anti-CBLC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (45281126..45303903). Location: 19q13.2
 OMIM    608453
 3D Structure    ModBase 3D Structure for Q9ULV8
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human Cbl.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.09% sodium azide.
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 Immunogen    Synthetic peptide selected from the N-terminal region of human Cbl-c (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-CBLC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CBLC antibody

   Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
 Product Categories/Family for anti-CBLC antibody    Antibodies; Abs to Transcription Factors, Zinc (Ring) Finger
 Applications Tested/Suitable for anti-CBLC antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CBLC antibody    Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
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NCBI/Uniprot data below describe general gene information for CBLC. It may not necessarily be applicable to this product.
 NCBI GI #    6291532
 NCBI GeneID    23624
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 UniProt Primary Accession #    Q9ULV8 [Other Products]
 UniProt Secondary Accession #    Q8N1E5; Q9Y5Z2; Q9Y5Z3 [Other Products]
 UniProt Related Accession #    Q9ULV8 [Other Products]
 Molecular Weight    52,456 Da [Similar Products]
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 NCBI Official Full Name    Cbl-c
 NCBI Official Synonym Full Names    Cas-Br-M (murine) ecotropic retroviral transforming sequence c
 NCBI Official Symbol    CBLC [Similar Products]
 NCBI Official Synonym Symbols   
CBL-3; RNF57; CBL-SL
[Similar Products]
 NCBI Protein Information    signal transduction protein CBL-C; OTTHUMP00000198327; OTTHUMP00000198328; RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Cas-Br-M (murine) ectropic retroviral transforming sequence c
 UniProt Protein Name    Signal transduction protein CBL-C
 UniProt Synonym Protein Names   
RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C
 Protein Family    E3 ubiquitin-protein ligase
 UniProt Gene Name    CBLC [Similar Products]
 UniProt Synonym Gene Names    CBL3; RNF57 [Similar Products]
 UniProt Entry Name    CBLC_HUMAN
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 NCBI Summary for CBLC    CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999 [PubMed 10362357]).[supplied by OMIM]
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 UniProt Comments for CBLC    Cbl-c: Regulator of EGFR mediated signal transduction. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin ligase; Ubiquitin conjugating system; Ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: nucleus

Molecular Function: signal transducer activity; zinc ion binding; phosphotyrosine binding; calcium ion binding; SH3 domain binding; epidermal growth factor receptor binding; ligase activity

Biological Process: negative regulation of epidermal growth factor receptor activity; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; cell surface receptor linked signal transduction; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination
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 Research Articles on CBLC    1. the N terminus of Cbl-c contributes to the binding to the E2 and phosphorylation of Tyr-341 leads to a decrease in affinity and an increase in the E3 activity of Cbl-c
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CBLC antibodyPathways associated with anti-CBLC antibody
 Reference Product  PubMed Publications
 SRC antibody  >4 publications with CBLC and SRC
 EGFR antibody  >3 publications with CBLC and EGFR
 ITCH antibody  >1 publications with CBLC and ITCH
 Products by Pathway  Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
Diseases associated with anti-CBLC antibodyOrgans/Tissues associated with anti-CBLC antibody
 Disease Name  Pubmed Publications
 Seizures Antibodies  >4 publications with CBLC and Seizures
 Retinal Degeneration Antibodies  >4 publications with CBLC and Retinal Degeneration
 Cell Transformation, Neoplastic Antibodies  >2 publications with CBLC and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >1 publications with CBLC and Adenocarcinoma
 Lung Neoplasms Antibodies  >1 publications with CBLC and Lung Neoplasms
 Craniofacial Abnormalities Antibodies  >1 publications with CBLC and Craniofacial Abnormalities
 Neural Tube Defects Antibodies  >1 publications with CBLC and Neural Tube Defects
 Neurodegenerative Diseases Antibodies  >1 publications with CBLC and Neurodegenerative Diseases
 Neurologic Manifestations Antibodies  >1 publications with CBLC and Neurologic Manifestations
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >8 publications with CBLC and Skin
 Brain Antibodies  >7 publications with CBLC and Brain
 Mammary Gland Antibodies  >1 publications with CBLC and Mammary Gland
 Lung Antibodies  >1 publications with CBLC and Lung
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