AAI44177.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 55 kDa Observed MW: 55-60 kDa
NCBI Official Full Name
CBLL1 protein
NCBI Official Synonym Full Names
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
NCBI Protein Information
E3 ubiquitin-protein ligase Hakai; Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1; Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1; E-cadherin binding protein E7; RING finger protein 188; c-Cbl-like protein 1; casitas B-lineage lymphoma-transforming sequence-like protein 1
UniProt Protein Name
E3 ubiquitin-protein ligase Hakai
UniProt Synonym Protein Names
Casitas B-lineage lymphoma-transforming sequence-like protein 1; RING finger protein 188; c-Cbl-like protein 1
UniProt Synonym Gene Names
UniProt Entry Name
HAKAI_HUMAN
NCBI Summary for CBLL1
This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]
UniProt Comments for CBLL1
CBLL1: Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation.
Protein type: EC 6.3.2.19; Ubiquitin ligase; Ubiquitin conjugating system; Cell adhesion; Motility/polarity/chemotaxis; C2H2-type zinc finger protein; Ligase; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 7q22.3
Cellular Component: ubiquitin ligase complex
Molecular Function: identical protein binding; protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity
Biological Process: cell-cell adhesion; protein ubiquitination; positive regulation of endocytosis; negative regulation of cell adhesion; positive regulation of cell migration
Research Articles on CBLL1
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Products associated with anti-CBLL1 antibody
Diseases associated with anti-CBLL1 antibody
Organs/Tissues associated with anti-CBLL1 antibody
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