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anti-CREBBP antibody :: Rabbit CBP, acetylated Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS613786 anti-CREBBP antibody
Unit / Price
0.1 mL  /  $590 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CBP, acetylated (CREBBP), Polyclonal Antibody

 Also Known As   

CBP, acetylated (Lys1535)/p300 (Lys1499) (CREB Binding Protein, Histone Acetyl Transferase, RTS, RSTS, Rubinstein-Taybi Syndrome)

 Product Synonym Names    Anti -CBP, acetylated (Lys1535)/p300 (Lys1499) (CREB Binding Protein, Histone Acetyl Transferase, RTS, RSTS, Rubinstein-Taybi Syndrome)
 Product Gene Name   

anti-CREBBP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_000016.9 (3775055..3930121, complement). Location: 16p13.3
 3D Structure    ModBase 3D Structure for O60424
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Monkey, Mouse, Rat
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 Specificity    Detects endogenous levels of CBP or p300 only when acetylated at lysine 1535 or lysine
 Purity/Purification    Affinity Purified
Purified by Protein A and immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in 10mM sodium HEPES, pH 7.5,, 150 mM NaCl, 100ug/ml BSA and 50% glycerol.
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 Immunogen    Synthetic acetylated peptide (KLH-coupled) corresponding to residues surrounding Lys1535 of human CBP.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-CREBBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CREBBP antibody

   CBP (CREB-binding protein) and p300 are highly conserved and functionally related transcriptional co-activators that associate with transcriptional regulators and signaling molecules, integrating multiple signal transduction pathways with the transcriptional machinery (1,2). CBP/p300 also contain histone acetyltransferase (HAT) activity, allowing them to acetylate histones and other proteins (2). Phosphorylation of p300 at Ser89 by PKC represses its transciptional acitivity, and phosphorylation at the same site by AMPK disrupts the association of p300 with nuclear receptors (3,4). Ser1834 phosphorylation of p300 by Akt disrupts its association with C/EBPb (5). Growth factors induce phosphorylation of CBP at Ser437, which is required for CBP recruitment to the transcription complex (6). CaM kinase IV phosphorylates CBP at Ser302, which is required for CBP-dependent transcriptional activation in the CNS(7). The role of acetylation of CBP/p300 is of particular interest (2,8). Acetylation of Lys1499 of p300 has been demonstrated to enhance its HAT activity and affect a wide variety of signaling events (9).
 Product Categories/Family for anti-CREBBP antibody    Antibodies; Abs to Disease Markers
 Applications Tested/Suitable for anti-CREBBP antibody   

Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-CREBBP antibody    Suitable for use in Western Blot, Immunoprecipitation.
Dilution: Western Blot: 1:1000
Immunoprecipitation: 1:50
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NCBI/Uniprot data below describe general gene information for CREBBP. It may not necessarily be applicable to this product.
 NCBI GI #    3168627
 NCBI GeneID    1387
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 UniProt Primary Accession #    O60424 [Other Products]
 UniProt Related Accession #    O60424; Q4G0V0; Q4LE28; Q712H6; Q75MY6; Q92793 [Other Products]
 Molecular Weight    101,798 Da [Similar Products]
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 NCBI Official Full Name    CBP
 NCBI Official Synonym Full Names    CREB binding protein
 NCBI Official Symbol    CREBBP [Similar Products]
 NCBI Official Synonym Symbols   
CBP; RSTS; KAT3A
[Similar Products]
 NCBI Protein Information    CREB-binding protein; OTTHUMP00000159801
 UniProt Protein Name    CBP
 Protein Family    CREB-binding protein
 UniProt Gene Name    CBP [Similar Products]
 UniProt Entry Name    O60424_HUMAN
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 NCBI Summary for CREBBP    This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
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 UniProt Comments for CREBBP    CBP: a protein acetyltransferase that can transcriptionally activate histones. Acetylates the NCOA3 coactivator. Binds specifically to phosphorylated CREB1 and enhances its transcriptional activity toward cAMP-responsive genes. Methylation of the KIX domain by CARM1 blocks association with CREB, blocking CREB signaling, and activating the apoptotic response. Found in a complex containing NCOA2, NCOA3, IKKA, IKKB, and IKBKG. Probably part of a complex with HIF1A and EP300. Interacts with the C-terminal region of CITED4. The TAZ-type 1 domain interacts with HIF1A. Interacts with MAF, SRCAP, CARM1, ELF3, MLLT7/FOXO4, N4BP2, NCOA1, NCOA3, NCOA6, PCAF, PELP1, PML, SMAD1, SMAD2, SMAD3, SPIB and TRERF1. Interacts with HTLV-1 Tax, p30II, and HIV-1 Tat. Interacts with KLF1; the interaction results in acetylation of KLF1 and enhancement of its transcriptional activity. Interacts with ZCCHC12. Interacts with DAXX; the interaction is dependent on CBP sumoylation and results in suppression of the transcriptional activiy via recruitment of HDAC2 to DAAX. Interacts with MTDH. Interacts with NFATC4. Interacts with MAFG; the interaction acetylates MAFG in the basic region and stimulates NFE2 transcriptional activity through increasing its DNA-binding activity. Interacts with IRF2; the interaction acetylates IRF2 and regulates its activity on the H4 promoter. Interacts via its N-terminus with the C-terminus of SS18L1. Interacts with MECOM. Chromosomal aberrations involving CBP may be a cause of acute myeloid leukemias. Known translocation partners include MYST3, MLL, and MYST4. MYST3-CBP fusion proteins may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1), an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.

Protein type: Acetyltransferase; Nuclear receptor co-regulator; DNA-binding; Transcription, coactivator/corepressor; Motility/polarity/chemotaxis; EC 2.3.1.48

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: nucleoplasm; nuclear body; transcription factor complex; cytoplasm; nuclear chromatin; outer kinetochore of condensed chromosome; nucleus; histone acetyltransferase complex

Molecular Function: MRF binding; protein binding; signal transducer activity; histone acetyltransferase activity; zinc ion binding; p53 binding; acetyltransferase activity; transcription coactivator activity; chromatin binding; transcription factor activity; transcription factor binding

Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; establishment and/or maintenance of chromatin architecture; viral reproduction; positive regulation of transcription, DNA-dependent; rhythmic process; germ-line stem cell maintenance; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; signal transduction; homeostatic process; regulation of transcription, DNA-dependent; positive regulation of interferon type I production; response to hypoxia; innate immune response; gene expression; protein complex assembly; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; histone acetylation; regulation of smoothened signaling pathway; N-terminal peptidyl-lysine acetylation

Disease: Rubinstein-taybi Syndrome 1
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 Research Articles on CREBBP    1. This study demonstrated an association between two polymorphisms in the CBP gene and cognitive function in an elderly population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CREBBP antibodyPathways associated with anti-CREBBP antibody
 Reference Product  PubMed Publications
 EP300 antibody  >108 publications with CREBBP and EP300
 NCOA1 antibody  >53 publications with CREBBP and NCOA1
 JUN antibody  >40 publications with CREBBP and JUN
 RELA antibody  >30 publications with CREBBP and RELA
 NCOA2 antibody  >24 publications with CREBBP and NCOA2
 MLL antibody  >23 publications with CREBBP and MLL
 STAT1 antibody  >23 publications with CREBBP and STAT1
 MYB antibody  >19 publications with CREBBP and MYB
 NCOA3 antibody  >19 publications with CREBBP and NCOA3
 PML antibody  >16 publications with CREBBP and PML
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
Diseases associated with anti-CREBBP antibodyOrgans/Tissues associated with anti-CREBBP antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >153 publications with CREBBP and Neoplasms
 Leukemia Antibodies  >90 publications with CREBBP and Leukemia
 Rubinstein-Taybi Syndrome Antibodies  >74 publications with CREBBP and Rubinstein-Taybi Syndrome
 Craniofacial Abnormalities Antibodies  >62 publications with CREBBP and Craniofacial Abnormalities
 Bone Diseases, Developmental Antibodies  >60 publications with CREBBP and Bone Diseases, Developmental
 Leukemia, Myeloid Antibodies  >49 publications with CREBBP and Leukemia, Myeloid
 Leukemia, Myeloid, Acute Antibodies  >42 publications with CREBBP and Leukemia, Myeloid, Acute
 Neurodegenerative Diseases Antibodies  >39 publications with CREBBP and Neurodegenerative Diseases
 Necrosis Antibodies  >31 publications with CREBBP and Necrosis
 Carcinoma Antibodies  >28 publications with CREBBP and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >127 publications with CREBBP and Brain
 Blood Antibodies  >84 publications with CREBBP and Blood
 Nerve Antibodies  >57 publications with CREBBP and Nerve
 Muscle Antibodies  >45 publications with CREBBP and Muscle
 Liver Antibodies  >31 publications with CREBBP and Liver
 Thyroid Antibodies  >29 publications with CREBBP and Thyroid
 Heart Antibodies  >25 publications with CREBBP and Heart
 Bone Antibodies  >23 publications with CREBBP and Bone
 Kidney Antibodies  >19 publications with CREBBP and Kidney
 Lung Antibodies  >19 publications with CREBBP and Lung
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