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anti-CBR1 antibody :: Rabbit anti-Human, Mouse CBR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7047821
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CBR1, Polyclonal Antibody

★Popular Item★
 Also Known As   

CBR1 Antibody

 Product Synonym Names    Carbonyl reductase [NADPH] 1; 15-hydroxyprostaglandin dehydrogenase [NADP(+)]; NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase; Short chain dehydrogenase/reductase family 21C member 1; CBR1; CBR; CRN; SDR21C1
 Product Gene Name   

anti-CBR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    J04056 mRNA
 3D Structure    ModBase 3D Structure for P16152
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Carbonyl reductase [NADPH] 1 protein (176-268AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-70212 / sc-70215
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CBR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CBR1 antibody

   NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
 Applications Tested/Suitable for anti-CBR1 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-CBR1 antibody    WB: 1: 500-1: 5000
IF: 1: 50-1: 200
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 Western Blot (WB) of anti-CBR1 antibody    Western Blot
Positive WB detected in:HEK293 whole cell lysate,PC3 whole cell lysate,Mouse kidney tissue,Mouse brain tissue
All lanes: CBR1 antibody at 2.5ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 31,19 kDa
Observed band size: 31 kDa

anti-CBR1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-CBR1 antibody    Immunofluorescent analysis of A549 cells using MBS7047821 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-CBR1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for CBR1. It may not necessarily be applicable to this product.
 NCBI GI #    557948119
 NCBI GeneID    873
 NCBI Accession #    NP_001273718.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001286789.1 [Other Products]
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 UniProt Primary Accession #    P16152 [Other Products]
 UniProt Secondary Accession #    Q3LHW8; B2RBZ7; B4DFK7 [Other Products]
 UniProt Related Accession #    P16152 [Other Products]
 Molecular Weight    18,762 Da
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 NCBI Official Full Name    carbonyl reductase
 NCBI Official Synonym Full Names    carbonyl reductase 1
 NCBI Official Symbol    CBR1 [Similar Products]
 NCBI Official Synonym Symbols   
CBR; hCBR1; SDR21C1
[Similar Products]
 NCBI Protein Information    carbonyl reductase [NADPH] 1
 UniProt Protein Name    Carbonyl reductase [NADPH] 1
 UniProt Synonym Protein Names   
15-hydroxyprostaglandin dehydrogenase [NADP(+)] (EC:1.1.1.197); NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase (EC:1.1.1.189); Short chain dehydrogenase/reductase family 21C member 1
 Protein Family    Carbonyl reductase
 UniProt Gene Name    CBR1 [Similar Products]
 UniProt Synonym Gene Names    CBR; CRN; SDR21C1 [Similar Products]
 UniProt Entry Name    CBR1_HUMAN
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 NCBI Summary for CBR1    The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
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 UniProt Comments for CBR1    CBR1: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: EC 1.1.1.184; EC 1.1.1.189; EC 1.1.1.197; Lipid Metabolism - arachidonic acid; Oxidoreductase

Chromosomal Location of Human Ortholog: 21q22.13

Cellular Component: cytosol

Molecular Function: carbonyl reductase (NADPH) activity; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; prostaglandin-E2 9-reductase activity

Biological Process: cyclooxygenase pathway; drug metabolic process; epithelial cell differentiation; vitamin K metabolic process
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 Research Articles on CBR1    1. These results suggest that CR1 induces apoptosis by activating the caspase pathway via binding to TNFR1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CBR1 antibodyPathways associated with anti-CBR1 antibody
 Reference Product  PubMed Publications
 AKR1B1 antibody  >10 publications with CBR1 and AKR1B1
 AKR1A1 antibody  >9 publications with CBR1 and AKR1A1
 GCH1 antibody  >1 publications with CBR1 and GCH1
 SPR antibody  >1 publications with CBR1 and SPR
 UBC antibody  >1 publications with CBR1 and UBC
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
Diseases associated with anti-CBR1 antibodyOrgans/Tissues associated with anti-CBR1 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >14 publications with CBR1 and Breast Neoplasms
 Disease Models, Animal Antibodies  >12 publications with CBR1 and Disease Models, Animal
 Liver Diseases Antibodies  >7 publications with CBR1 and Liver Diseases
 Liver Neoplasms Antibodies  >5 publications with CBR1 and Liver Neoplasms
 Necrosis Antibodies  >5 publications with CBR1 and Necrosis
 Brain Diseases Antibodies  >4 publications with CBR1 and Brain Diseases
 Lung Neoplasms Antibodies  >4 publications with CBR1 and Lung Neoplasms
 Drug-Related Side Effects and Adverse Reactions Antibodies  >4 publications with CBR1 and Drug-Related Side Effects and Adverse Reactions
 Heart Diseases Antibodies  >4 publications with CBR1 and Heart Diseases
 Fibrosis Antibodies  >4 publications with CBR1 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >28 publications with CBR1 and Liver
 Brain Antibodies  >16 publications with CBR1 and Brain
 Blood Antibodies  >13 publications with CBR1 and Blood
 Uterus Antibodies  >10 publications with CBR1 and Uterus
 Heart Antibodies  >8 publications with CBR1 and Heart
 Ovary Antibodies  >6 publications with CBR1 and Ovary
 Lung Antibodies  >6 publications with CBR1 and Lung
 Muscle Antibodies  >5 publications with CBR1 and Muscle
 Embryonic Tissue Antibodies  >4 publications with CBR1 and Embryonic Tissue
 Nerve Antibodies  >4 publications with CBR1 and Nerve
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