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anti-CBX4 antibody :: Rabbit CBX4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150226
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CBX4, Polyclonal Antibody

 Also Known As   

CBX4 Antibody

 Product Synonym Names    CBX4; PC2; NBP16; E3 SUMO-protein ligase CBX4; Chromobox protein homolog 4; Pc2; chromobox homolog 4
 Product Gene Name   

anti-CBX4 antibody

[Similar Products]
 Antibody/Peptide Pairs    CBX4 peptide (MBS152340) is used for blocking the activity of CBX4 antibody (MBS150226)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603079
 3D Structure    ModBase 3D Structure for O00257
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Two alternatively spliced transcript variants have been observed.
 Purity/Purification    CBX4 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    CBX4 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CBX4.
 Buffer    CBX4 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    CBX4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-CBX4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CBX4 antibody

   CBX4 Antibody: Polycomb group (PcG) proteins are chromatin-associated proteins which are important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1 and RING domain-containing proteins (RING1, RING2 and BMI1). CBX4 (Chromobox protein homolog 4 or PC2), which functions as a transcriptional suppressor, is a candidate of KyoT2-binding proteins. It is a E3 SUMO-protein ligase which facilitates SUMO1 conjugation. Depletion of CBX4 results in decreased cellular resistance to ionizing radiation. CBX4 is directly involved in the cellular response to DNA damage.
 Applications Tested/Suitable for anti-CBX4 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-CBX4 antibody    CBX4 antibody can be used for detection of CBX4 by Western blot at 1 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-CBX4 antibody    Western blot analysis of CBX4 in human brain tissue lysate with CBX4 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
anti-CBX4 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-CBX4 antibody    Immunofluorescence of CBX4 in human brain tissue with CBX4 antibody at 20 μg/mL.
anti-CBX4 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for CBX4. It may not necessarily be applicable to this product.
 NCBI GI #    55770830
 NCBI GeneID    8535
 NCBI Accession #    NP_003646 [Other Products]
 NCBI GenBank Nucleotide #    NM_003655.2 [Other Products]
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 UniProt Primary Accession #    O00257 [Other Products]
 UniProt Secondary Accession #    Q6TPI8; Q96C04; B1PJR7 [Other Products]
 UniProt Related Accession #    O00257 [Other Products]
 Molecular Weight    62 kDa
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 NCBI Official Full Name    E3 SUMO-protein ligase CBX4
 NCBI Official Synonym Full Names    chromobox homolog 4
 NCBI Official Symbol    CBX4 [Similar Products]
 NCBI Official Synonym Symbols   
PC2; NBP16
[Similar Products]
 NCBI Protein Information    E3 SUMO-protein ligase CBX4; Pc class 2 homolog; polycomb 2 homolog; NS5ATP1-binding protein 16; chromobox protein homolog 4; chromobox homolog 4 (Pc class homolog, Drosophila)
 UniProt Protein Name    E3 SUMO-protein ligase CBX4
 UniProt Synonym Protein Names   
Chromobox protein homolog 4; Polycomb 2 homolog; Pc2; hPc2
 Protein Family    E3 SUMO-protein ligase
 UniProt Gene Name    CBX4 [Similar Products]
 UniProt Synonym Gene Names    Pc2; hPc2 [Similar Products]
 UniProt Entry Name    CBX4_HUMAN
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 UniProt Comments for CBX4    CBX4: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; SUMO ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: nucleoplasm; nuclear speck; PcG protein complex; nucleus

Molecular Function: protein binding; enzyme binding; single-stranded RNA binding; SUMO binding; phosphoprotein binding; chromatin binding; transcription corepressor activity; methylated histone residue binding; ligase activity

Biological Process: protein sumoylation; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis
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 Research Articles on CBX4    1. The presence of CBX4-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CBX4 antibodyPathways associated with anti-CBX4 antibody
 Reference Product  PubMed Publications
 BMI1 antibody  >15 publications with CBX4 and BMI1
 RING1 antibody  >11 publications with CBX4 and RING1
 EZH2 antibody  >10 publications with CBX4 and EZH2
 CBX8 antibody  >8 publications with CBX4 and CBX8
 RNF2 antibody  >3 publications with CBX4 and RNF2
 PHC1 antibody  >2 publications with CBX4 and PHC1
 PHC2 antibody  >1 publications with CBX4 and PHC2
 PCGF2 antibody  >1 publications with CBX4 and PCGF2
 CTBP1 antibody  >1 publications with CBX4 and CTBP1
 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Oxidative Stress Induced Senescence Pathway antibodies  Oxidative Stress Induced Senescence Pathway Diagram
 Regulation Of Retinoblastoma Protein Pathway antibodies  Regulation Of Retinoblastoma Protein Pathway Diagram
Diseases associated with anti-CBX4 antibodyOrgans/Tissues associated with anti-CBX4 antibody
 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >5 publications with CBX4 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >2 publications with CBX4 and Liver Neoplasms
 Liver Diseases Antibodies  >2 publications with CBX4 and Liver Diseases
 Disease Models, Animal Antibodies  >2 publications with CBX4 and Disease Models, Animal
 Immune System Diseases Antibodies  >1 publications with CBX4 and Immune System Diseases
 Breast Neoplasms Antibodies  >1 publications with CBX4 and Breast Neoplasms
 Inflammation Antibodies  >1 publications with CBX4 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with CBX4 and Blood
 Liver Antibodies  >3 publications with CBX4 and Liver
 Vascular Antibodies  >2 publications with CBX4 and Vascular
 Kidney Antibodies  >2 publications with CBX4 and Kidney
 Prostate Antibodies  >2 publications with CBX4 and Prostate
 Ovary Antibodies  >1 publications with CBX4 and Ovary
 Skin Antibodies  >1 publications with CBX4 and Skin
 Thymus Antibodies  >1 publications with CBX4 and Thymus
 Brain Antibodies  >1 publications with CBX4 and Brain
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