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anti-CBX5 antibody :: Goat CBX5/HP1-Alpha Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420702
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CBX5/HP1-Alpha, Polyclonal Antibody

 Also Known As   

Goat anti-CBX5/HP1-Alpha Antibody

 Product Synonym Names    CBX5; HP1-ALPHA; chromobox homolog 5 (HP1 alpha homolog, Drosophila); HGNC: 1555; HP1; HP1Hs-alpha; chromobox homolog 5 (Drosophila HP1 alpha); Heterochromatin protein-1; HP1A; antigen p25; heterochromatin protein 1 homolog alpha; heterochromatin protein; CBX5 antibody; HP1-ALPHA antibody; chromobox homolog 5 (HP1 alpha homolog; Drosophila) antibody; HGNC: 1555 antibody; HP1 antibody; HP1Hs-alpha antibody; chromobox homolog 5 (Drosophila HP1 alpha) antibody; Heterochromatin protein-1 antibody; HP1A antibody; antigen p25 antibody; heterochromatin protein 1 homolog alpha antibody; heterochromatin protein 1-alpha antibody; CBX5 / HP1-Alpha
 Product Gene Name   

anti-CBX5 antibody

[Similar Products]
 Product Synonym Gene Name    HP1-Alpha [Similar Products]
 Matching Pairs    Unconjugated Antibody: CBX5/HP1-Alpha (MBS420702)
Biotin Conjugated Antibody: CBX5/HP1-Alpha (MBS423571)
 Antibody/Peptide Pairs    CBX5 / HP1-Alpha peptide (MBS425815) is used for blocking the activity of CBX5/HP1-Alpha antibody (MBS420702)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    NKRKSNFSNS ADDIK
 OMIM    604478
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-NKRKSNFSNSADDIK, from the internal region of the protein sequence according to NP_036249.1; NP_001120793.1; NP_001120794.1.
 Epitope    Internal region
 Note    Variants (NP_036249.1; NP_001120793.1; NP_001120794.1) encode the same protein.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CBX5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CBX5 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CBX5 antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Immunohistochemistry: In paraffin embedded Human Uterus shows strong nuclear staining in the glandular epithelial cells. Recommended concentration, 2-3ug/ml.
Western Blot: Approx.22kDa band observed in lysates of Human fibroblast cell lines A431 and HeLa (calculated MW of 22.2kDa according to NP_036249.1). Recommended concentration: 0. 03-0.1ug/ml.
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 Western Blot (WB) of anti-CBX5 antibody    (0. 03ug/ml) staining of Hela lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-CBX5 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CBX5 antibody    (2.5ug/ml) staining of paraffin embedded Human Uterus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-CBX5 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CBX5. It may not necessarily be applicable to this product.
 NCBI GI #    6912292
 NCBI GeneID    23468
 NCBI Accession #    NP_036249.1 [Other Products]
 NCBI Related Accession #    NP_001120793.1; NP_001120794.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012117.2 [Other Products]
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 UniProt Secondary Accession #    B2R8T9 [Other Products]
 UniProt Related Accession #    P45973 [Other Products]
 Molecular Weight    22,225 Da
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 NCBI Official Full Name    chromobox protein homolog 5
 NCBI Official Synonym Full Names    chromobox 5
 NCBI Official Symbol    CBX5 [Similar Products]
 NCBI Official Synonym Symbols   
HP1; HP1A; HEL25
[Similar Products]
 NCBI Protein Information    chromobox protein homolog 5
 UniProt Protein Name    Chromobox protein homolog 5
 UniProt Synonym Protein Names   
Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha
 Protein Family    Chromobox protein
 UniProt Gene Name    CBX5 [Similar Products]
 UniProt Synonym Gene Names    HP1A; HP1 alpha [Similar Products]
 UniProt Entry Name    CBX5_HUMAN
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 NCBI Summary for CBX5    This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CBX5    HP1 alpha: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Interacts with SUV420H1 and SUV420H2. Interacts with HP1BP3. Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain. Can interact directly with CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at 'Lys- 9'. Interacts with BAHD1, MIS12 and DSN1. Interacts with POGZ; POGZ and PXVXL motif-containing proteins such as INCENP and TRIM28 compete for interaction with CBX5. Interacts with INCENP and TRIM24. Interacts with JC virus agnoprotein; this interaction induces the dissociation of CBX5 from LBR, resulting in destabilization of the nuclear envelope. Interacts with CHAMP1. Interacts with ASXL1.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: centric heterochromatin; chromocenter; histone deacetylase complex; histone methyltransferase complex; kinetochore; nuclear chromosome, telomeric region; nuclear envelope; nuclear heterochromatin; nucleolus; nucleoplasm; nucleus; PML body; transcriptional repressor complex

Molecular Function: chromatin binding; histone deacetylase binding; methylated histone residue binding; protein binding; protein binding, bridging; protein homodimerization activity

Biological Process: blood coagulation; negative regulation of transcription, DNA-dependent; viral reproduction
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 Research Articles on CBX5    1. HP1alpha plays an important role in the differentiation and angiogenic function of Endothelial Progenitor Cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CBX5 antibodyPathways associated with anti-CBX5 antibody
 Reference Product  PubMed Publications
 CBX3 antibody  >12 publications with CBX5 and CBX3
 SUV39H1 antibody  >2 publications with CBX5 and SUV39H1
 DNMT3B antibody  >2 publications with CBX5 and DNMT3B
 TRIM28 antibody  >2 publications with CBX5 and TRIM28
 ATRX antibody  >1 publications with CBX5 and ATRX
 Products by Pathway  Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-CBX5 antibodyOrgans/Tissues associated with anti-CBX5 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >3 publications with CBX5 and Disease Models, Animal
 Breast Neoplasms Antibodies  >3 publications with CBX5 and Breast Neoplasms
 Lung Diseases Antibodies  >2 publications with CBX5 and Lung Diseases
 Lung Neoplasms Antibodies  >2 publications with CBX5 and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with CBX5 and Cell Transformation, Neoplastic
 Anemia Antibodies  >1 publications with CBX5 and Anemia
 Neurobehavioral Manifestations Antibodies  >1 publications with CBX5 and Neurobehavioral Manifestations
 Neoplasms, Experimental Antibodies  >1 publications with CBX5 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >4 publications with CBX5 and Embryonic Tissue
 Blood Antibodies  >3 publications with CBX5 and Blood
 Lung Antibodies  >2 publications with CBX5 and Lung
 Kidney Antibodies  >2 publications with CBX5 and Kidney
 Intestine Antibodies  >2 publications with CBX5 and Intestine
 Liver Antibodies  >2 publications with CBX5 and Liver
 Vascular Antibodies  >2 publications with CBX5 and Vascular
 Placenta Antibodies  >1 publications with CBX5 and Placenta
 Stomach Antibodies  >1 publications with CBX5 and Stomach
 Connective Tissue Antibodies  >1 publications with CBX5 and Connective Tissue
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