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anti-CBX8 antibody :: Goat CBX8 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420413
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CBX8, Polyclonal Antibody

 Also Known As   

Goat anti-CBX8 Antibody

 Product Synonym Names    CBX8; chromobox homolog 8 (Pc class homolog, Drosophila); HPC3; PC3; RC1; chromobox homolog 8; polycomb 3; CBX8 antibody; chromobox homolog 8 (Pc class homolog; Drosophila) antibody; HPC3 antibody; PC3 antibody; RC1 antibody; chromobox homolog 8 antibody; polycomb 3 antibody
 Product Gene Name   

anti-CBX8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
 Antibody/Peptide Pairs    CBX8 peptide (MBS426408) is used for blocking the activity of CBX8 antibody (MBS420413)
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 Immunogen Sequence    RERGTSRVDD KPSS
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-RERGTSRVDDKPSS, from the internal region of the protein sequence according to NP_065700.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CBX8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CBX8 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-CBX8 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
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 Western Blot (WB) of anti-CBX8 antibody    (0.1ug/ml) staining of K562 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-CBX8 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CBX8. It may not necessarily be applicable to this product.
 NCBI GI #    10190682
 NCBI GeneID    57332
 NCBI Accession #    NP_065700.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020649.2 [Other Products]
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 UniProt Secondary Accession #    Q96H39; Q9NR07 [Other Products]
 UniProt Related Accession #    Q9HC52 [Other Products]
 Molecular Weight    43,396 Da
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 NCBI Official Full Name    chromobox protein homolog 8
 NCBI Official Synonym Full Names    chromobox 8
 NCBI Official Symbol    CBX8 [Similar Products]
 NCBI Official Synonym Symbols   
PC3; RC1
[Similar Products]
 NCBI Protein Information    chromobox protein homolog 8
 UniProt Protein Name    Chromobox protein homolog 8
 UniProt Synonym Protein Names   
Polycomb 3 homolog; Pc3; hPc3; Rectachrome 1
 Protein Family    Chromobox protein
 UniProt Gene Name    CBX8 [Similar Products]
 UniProt Synonym Gene Names    PC3; RC1; Pc3; hPc3 [Similar Products]
 UniProt Entry Name    CBX8_HUMAN
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 UniProt Comments for CBX8    CBX8: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: heterochromatin; nuclear chromatin; nucleoplasm; nucleus; PcG protein complex

Molecular Function: methylated histone residue binding; protein binding; single-stranded RNA binding

Biological Process: histone ubiquitination; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of DNA repair; protein sumoylation; regulation of catalytic activity; transcription, DNA-dependent
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 Research Articles on CBX8    1. Low CBX8 expression was associated with distant metastasis in colorectal cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Goat anti-CBX8 Antibody
 Catalog #  Product Name  Catalog #  Product Name
 MBS1278486  CBX8 cDNA Clone  MBS9208747  CBX8 Antibody (Center)
 MBS7227871  Canine Chromobox protein homolog 8 (CBX8) ELISA Kit  MBS9230040  CBX8 Blocking Peptide (Center)
 MBS426408  CBX8 Immunizing Peptide  MBS421248  Goat anti-CBX6 and CBX8 Antibody
 MBS7249465  Guinea pig Chromobox protein homolog 8 (CBX8) ELISA Kit  MBS9403731  CBX8 Antibody
 MBS9401833  CBX8 antibody  MBS2528072  CBX8 Polyclonal Antibody
Products associated with anti-CBX8 antibodyPathways associated with anti-CBX8 antibody
 Reference Product  PubMed Publications
 BMI1 antibody  >6 publications with CBX8 and BMI1
 EZH2 antibody  >5 publications with CBX8 and EZH2
 MLLT3 antibody  >2 publications with CBX8 and MLLT3
 PHC2 antibody  >2 publications with CBX8 and PHC2
 RNF2 antibody  >2 publications with CBX8 and RNF2
 SUZ12 antibody  >1 publications with CBX8 and SUZ12
 PCGF2 antibody  >1 publications with CBX8 and PCGF2
 Products by Pathway  Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Oxidative Stress Induced Senescence Pathway antibodies  Oxidative Stress Induced Senescence Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 SUMO E3 Ligases SUMOylate Target Proteins Pathway antibodies  SUMO E3 Ligases SUMOylate Target Proteins Pathway Diagram
 SUMOylation Pathway antibodies  SUMOylation Pathway Diagram
 SUMOylation Of DNA Damage Response And Repair Proteins Pathway antibodies  SUMOylation Of DNA Damage Response And Repair Proteins Pathway Diagram
 SUMOylation Of RNA Binding Proteins Pathway antibodies  SUMOylation Of RNA Binding Proteins Pathway Diagram
Diseases associated with anti-CBX8 antibodyOrgans/Tissues associated with anti-CBX8 antibody
 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >2 publications with CBX8 and Cell Transformation, Neoplastic
 Memory Disorders Antibodies  >1 publications with CBX8 and Memory Disorders
 Brain Diseases Antibodies  >1 publications with CBX8 and Brain Diseases
 Liver Neoplasms Antibodies  >1 publications with CBX8 and Liver Neoplasms
 Death Antibodies  >1 publications with CBX8 and Death
 Disease Models, Animal Antibodies  >1 publications with CBX8 and Disease Models, Animal
 Liver Diseases Antibodies  >1 publications with CBX8 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2 publications with CBX8 and Bone
 Brain Antibodies  >2 publications with CBX8 and Brain
 Lung Antibodies  >2 publications with CBX8 and Lung
 Prostate Antibodies  >1 publications with CBX8 and Prostate
 Bone Marrow Antibodies  >1 publications with CBX8 and Bone Marrow
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