NP_001002880.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
protein chibby homolog 1 isoform b
NCBI Official Synonym Full Names
chibby family member 1, beta catenin antagonist
NCBI Official Synonym Symbols
CBY; arb1; PGEA1; C22orf2; PIGEA14; PIGEA-14; HS508I15A [Similar Products]
NCBI Protein Information
protein chibby homolog 1
UniProt Protein Name
Protein chibby homolog 1
UniProt Synonym Protein Names
ARPP-binding protein; Cytosolic leucine-rich protein; PIGEA-14; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
UniProt Synonym Gene Names
UniProt Entry Name
CBY1_HUMAN
NCBI Summary for CBY1
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CBY1
CBY1: Inhibits the Wnt/Wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Belongs to the chibby family.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 22q12
Cellular Component: cytosol; nucleoplasm; nucleus; trans-Golgi network
Molecular Function: beta-catenin binding; identical protein binding; protein binding
Biological Process: cardiac muscle cell differentiation; fat cell differentiation; negative regulation of transcription, DNA-dependent; negative regulation of Wnt receptor signaling pathway; protein localization
Research Articles on CBY1
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Products associated with anti-CBY1 antibody
Pathways associated with anti-CBY1 antibody
Diseases associated with anti-CBY1 antibody
Organs/Tissues associated with anti-CBY1 antibody
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