Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow CCL21 rightarrow Polyclonal CCL21  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • EFNA1 ELISA Kit
 • Trichosanthes kirilowii Ribosome-inactivating protein alpha-... Recombinant Protein
 • SSB IgG ELISA Kit
 • CEA Antibody
 • CD100 Antibody
 • PMN, Adsorbed Antiserum Antibody
 • ORP5 (OSBPL5) Antibody
 • Sialate O-acetylesterase (Siae) Recombinant Protein
 • general transcription factor IIIC, polypeptide 3, 102kDa (GT... ELISA Kit
 • Aggrecan, C-terminal neoepitope NITEGE Antibody
 • CD40 Antibody
 • CD2 Antibody
 • CRTH2 (GPR44) Blocking Peptide
 • GABRB2 cDNA Clone
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-CCL21 antibody :: Rabbit anti-Human CCL21 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS127186
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CCL21, Polyclonal Antibody

 Also Known As   

CCL21 Polyclonal Antibody

 Product Synonym Names    ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21
 Product Gene Name   

anti-CCL21 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    602737
 3D Structure    ModBase 3D Structure for O00585
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
Section Bar
 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human CCL21
 Calculated Molecular Weight    15kDa
Section Bar
 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-CCL21 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-CCL21 antibody

   This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).
 Product Categories/Family for anti-CCL21 antibody    Polyclonal
 Applications Tested/Suitable for anti-CCL21 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CCL21 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
Section Bar
 Western Blot (WB) of anti-CCL21 antibody    Western blot analysis of extracts of Caco-2 cell lysate, using CCL21 antibody.
anti-CCL21 antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CCL21. It may not necessarily be applicable to this product.
 NCBI GI #    6094386
 NCBI GeneID    6366
 NCBI Accession #    O00585.1 [Other Products]
Section Bar
 UniProt Primary Accession #    O00585 [Other Products]
 UniProt Related Accession #    O00585 [Other Products]
 Molecular Weight    134
Table BarTOPTable Bar
 NCBI Official Full Name    C-C motif chemokine 21
 NCBI Official Synonym Full Names    chemokine (C-C motif) ligand 21
 NCBI Official Symbol    CCL21 [Similar Products]
 NCBI Official Synonym Symbols   
ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 21; beta chemokine exodus-2; secondary lymphoid tissue chemokine; Efficient Chemoattractant for Lymphocytes; small inducible cytokine subfamily A (Cys-Cys), member 21
 UniProt Protein Name    C-C motif chemokine 21
 UniProt Synonym Protein Names   
6Ckine; Beta-chemokine exodus-2; Secondary lymphoid-tissue chemokine; SLC; Small-inducible cytokine A21
 Protein Family    C-C motif chemokine
 UniProt Gene Name    CCL21 [Similar Products]
 UniProt Synonym Gene Names    SCYA21; SLC [Similar Products]
 UniProt Entry Name    CCL21_HUMAN
Section Bar
 NCBI Summary for CCL21    This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]
Section Bar
 UniProt Comments for CCL21    CCL21: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Secreted, signal peptide; Chemokine; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine receptor binding; chemokine activity; CCR7 chemokine receptor binding

Biological Process: positive regulation of filopodium formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; formation of immunological synapse; positive regulation of chemotaxis; positive regulation of dendritic cell antigen processing and presentation; cell maturation; positive regulation of JNK cascade; positive regulation of phosphoinositide 3-kinase activity; positive regulation of cell adhesion mediated by integrin; positive regulation of receptor-mediated endocytosis; G-protein coupled receptor protein signaling pathway; positive regulation of protein kinase B signaling cascade; positive regulation of pseudopodium formation; positive regulation of actin filament polymerization; cell-cell signaling; positive regulation of protein kinase activity; release of sequestered calcium ion into cytosol; T cell costimulation; ruffle organization and biogenesis; dendritic cell chemotaxis; establishment of T cell polarity; immune response; positive regulation of cell-matrix adhesion; inflammatory response
Table BarTOPTable Bar
 Research Articles on CCL21    1. CCL21 was shown to be involved in the induction of ulcerative colitis. Suppression of CCL21 expression decreased damage induced from ulcerative colitis, indicating that CCL21 targeted therapy might be an effective treatment for this disease
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-CCL21 antibodyPathways associated with anti-CCL21 antibody
 Reference Product  PubMed Publications
 CCR7 antibody  >470 publications with CCL21 and CCR7
 CXCL13 antibody  >122 publications with CCL21 and CXCL13
 CXCL10 antibody  >61 publications with CCL21 and CXCL10
 CCR6 antibody  >41 publications with CCL21 and CCR6
 CXCL9 antibody  >36 publications with CCL21 and CXCL9
 CXCR5 antibody  >28 publications with CCL21 and CXCR5
 CCR5 antibody  >26 publications with CCL21 and CCR5
 CXCL11 antibody  >15 publications with CCL21 and CXCL11
 CCL27 antibody  >14 publications with CCL21 and CCL27
 CCR1 antibody  >9 publications with CCL21 and CCR1
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
Diseases associated with anti-CCL21 antibodyOrgans/Tissues associated with anti-CCL21 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >190 publications with CCL21 and Inflammation
 Autoimmune Diseases Antibodies  >94 publications with CCL21 and Autoimmune Diseases
 Disease Models, Animal Antibodies  >92 publications with CCL21 and Disease Models, Animal
 Necrosis Antibodies  >81 publications with CCL21 and Necrosis
 Nervous System Diseases Antibodies  >53 publications with CCL21 and Nervous System Diseases
 Arthritis, Rheumatoid Antibodies  >52 publications with CCL21 and Arthritis, Rheumatoid
 Lung Diseases Antibodies  >50 publications with CCL21 and Lung Diseases
 Vascular Diseases Antibodies  >46 publications with CCL21 and Vascular Diseases
 Cardiovascular Diseases Antibodies  >34 publications with CCL21 and Cardiovascular Diseases
 Intestinal Diseases Antibodies  >31 publications with CCL21 and Intestinal Diseases
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >386 publications with CCL21 and Lymph Node
 Vascular Antibodies  >142 publications with CCL21 and Vascular
 Spleen Antibodies  >101 publications with CCL21 and Spleen
 Lung Antibodies  >85 publications with CCL21 and Lung
 Liver Antibodies  >49 publications with CCL21 and Liver
 Embryonic Tissue Antibodies  >30 publications with CCL21 and Embryonic Tissue
 Kidney Antibodies  >26 publications with CCL21 and Kidney
 Muscle Antibodies  >22 publications with CCL21 and Muscle
 Pancreas Antibodies  >22 publications with CCL21 and Pancreas
 Intestine Antibodies  >20 publications with CCL21 and Intestine
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions