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anti-CCL4 antibody :: Rabbit anti-Human CCL4 / SYCA4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS248019
Immunohistochemistry (IHC)
Unit / Price
0.05 mL  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CCL4 / SYCA4, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal (IgG) to Human CCL4 / SYCA4

 Product Synonym Names    Anti-CCL4 / SYCA4 Antibody (aa19-92) IHC-plus; CCL4; ACT2; Act-2; AT744.1; C-C motif chemokine 4; Chemokine (C-C motif) ligand 4; CC chemokine ligand 4; HC21; LAG1; MIP1B; MIP1B1; LAG-1; SCYA2; Secreted protein G-26; SIS-gamma; MIP-1-beta; MIP-1-beta(1-69); Small-inducible cytokine A4; Human CCL4; SYCA4
 Product Gene Name   

anti-CCL4 antibody

[Similar Products]
 Product Synonym Gene Name    SYCA4 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    182284
 3D Structure    ModBase 3D Structure for P13236
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Human CCL4 / SYCA4
 Purity/Purification    Immunoaffinity Purified
 Form/Format    0.1 M Tris-glycine, pH 7, 10% Glycerol, 0.01% Thimerosal
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide corresponding to a region within amino acids 19 and 92 of CCL4. Percent identity by BLAST analysis: Human (100%).
 Immunogen Type    Synthetic peptide
 Immunogen    CCL4 / SYCA4 antibody was raised against synthetic peptide corresponding to a region within amino acids 19 and 92 of CCL4. Percent identity by BLAST analysis: Human (100%).
 Antigen Modification    aa19-92
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 Preparation and Storage    Keep as concentrated solution. Aliquot and store at -20 degree C or below. Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of anti-CCL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CCL4 antibody    Family: Intercrine
Subfamily: Intercrine beta
 Applications Tested/Suitable for anti-CCL4 antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-CCL4 antibody    ELISA, IHC-P (10 ug/ml)
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 Immunohistochemistry (IHC) of anti-CCL4 antibody    Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
anti-CCL4 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CCL4. It may not necessarily be applicable to this product.
 NCBI GI #    4506845
 NCBI GeneID    6351
 NCBI Accession #    NP_002975.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002984.2 [Other Products]
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 UniProt Primary Accession #    P13236 [Other Products]
 UniProt Secondary Accession #    P22617; Q13704; Q3SXL8; Q6FGI8 [Other Products]
 UniProt Related Accession #    P13236 [Other Products]
 Molecular Weight    10,212 Da
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 NCBI Official Full Name    C-C motif chemokine 4
 NCBI Official Synonym Full Names    chemokine (C-C motif) ligand 4
 NCBI Official Symbol    CCL4 [Similar Products]
 NCBI Official Synonym Symbols   
ACT2; G-26; HC21; LAG1; LAG-1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MIP-1-beta
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 4; PAT 744; SIS-gamma; MIP-1-beta(1-69); secreted protein G-26; T-cell activation protein 2; G-26 T-lymphocyte-secreted protein; lymphocyte activation gene 1 protein; macrophage inflammatory protein 1-beta; small inducible cytokine A4 (homologous to mouse Mip-1b)
 UniProt Protein Name    C-C motif chemokine 4
 UniProt Synonym Protein Names   
G-26 T-lymphocyte-secreted protein; HC21; Lymphocyte activation gene 1 protein; LAG-1; MIP-1-beta(1-69); Macrophage inflammatory protein 1-beta; MIP-1-beta; PAT 744; Protein H400; SIS-gamma; Small-inducible cytokine A4; T-cell activation protein 2; ACT-2
 Protein Family    C-C motif chemokine
 UniProt Gene Name    CCL4 [Similar Products]
 UniProt Synonym Gene Names    LAG1; MIP1B; SCYA4; LAG-1; MIP-1-beta; ACT-2 [Similar Products]
 UniProt Entry Name    CCL4_HUMAN
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 NCBI Summary for CCL4    The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]
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 UniProt Comments for CCL4    CCL4: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Chemokine

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space; extracellular region

Molecular Function: identical protein binding; CCR1 chemokine receptor binding; protein binding; chemokine activity; cytokine activity; CCR5 chemokine receptor binding

Biological Process: cell-cell signaling; response to virus; response to toxin; establishment and/or maintenance of cell polarity; immune response; positive regulation of calcium-mediated signaling; cell adhesion; signal transduction; positive regulation of calcium ion transport; cell motility; inflammatory response
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 Research Articles on CCL4    1. The allele and genotype frequencies of CCL2, CCL3 and CCL4 were not different between HCs and patients with PTB.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CCL4 antibodyPathways associated with anti-CCL4 antibody
 Reference Product  PubMed Publications
 CCL3 antibody  >1609 publications with CCL4 and CCL3
 CCR5 antibody  >591 publications with CCL4 and CCR5
 CCR1 antibody  >197 publications with CCL4 and CCR1
 CXCL2 antibody  >187 publications with CCL4 and CXCL2
 CCR2 antibody  >108 publications with CCL4 and CCR2
 CXCR3 antibody  >75 publications with CCL4 and CXCR3
 CCR3 antibody  >71 publications with CCL4 and CCR3
 CCR7 antibody  >53 publications with CCL4 and CCR7
 CCR8 antibody  >24 publications with CCL4 and CCR8
 IL1B antibody  >14 publications with CCL4 and IL1B
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
Diseases associated with anti-CCL4 antibodyOrgans/Tissues associated with anti-CCL4 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >690 publications with CCL4 and Immune System Diseases
 Protein Deficiency Antibodies  >157 publications with CCL4 and Protein Deficiency
 Bone Diseases Antibodies  >105 publications with CCL4 and Bone Diseases
 Hypertension, Portal Antibodies  >90 publications with CCL4 and Hypertension, Portal
 Disease Susceptibility Antibodies  >77 publications with CCL4 and Disease Susceptibility
 Gastrointestinal Diseases Antibodies  >76 publications with CCL4 and Gastrointestinal Diseases
 Eye Diseases Antibodies  >71 publications with CCL4 and Eye Diseases
 Asthma Antibodies  >68 publications with CCL4 and Asthma
 Pneumonia Antibodies  >67 publications with CCL4 and Pneumonia
 Ischemia Antibodies  >61 publications with CCL4 and Ischemia
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4330 publications with CCL4 and Liver
 Blood Antibodies  >3240 publications with CCL4 and Blood
 Lung Antibodies  >400 publications with CCL4 and Lung
 Bone Marrow Antibodies  >299 publications with CCL4 and Bone Marrow
 Kidney Antibodies  >284 publications with CCL4 and Kidney
 Intestine Antibodies  >116 publications with CCL4 and Intestine
 Lymph Antibodies  >109 publications with CCL4 and Lymph
 Parathyroid Antibodies  >14 publications with CCL4 and Parathyroid
 Prostate Antibodies  >11 publications with CCL4 and Prostate
 Adrenal Gland Antibodies  >7 publications with CCL4 and Adrenal Gland
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