NP_001286.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,173 Da
NCBI Official Full Name
C-C chemokine receptor type 1
NCBI Official Synonym Full Names
chemokine (C-C motif) receptor 1
NCBI Official Synonym Symbols
CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1 [Similar Products]
NCBI Protein Information
C-C chemokine receptor type 1; CCR-1; CC-CKR-1; RANTES-R; C-C CKR-1; MIP-1alpha-R; LD78 receptor; RANTES receptor; macrophage inflammatory protein 1-alpha receptor
UniProt Protein Name
C-C chemokine receptor type 1
UniProt Synonym Protein Names
HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; CD_antigen: CD191
UniProt Synonym Gene Names
CMKBR1; CMKR1; SCYAR1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; MIP-1alpha-R [Similar Products]
UniProt Entry Name
CCR1_HUMAN
NCBI Summary for CCR1
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]
UniProt Comments for CCR1
CCR1: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. Belongs to the G-protein coupled receptor 1 family.
Protein type: Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3p21
Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane
Molecular Function: protein binding; C-C chemokine receptor activity; chemokine receptor activity; C-C chemokine binding; phosphoinositide phospholipase C activity
Biological Process: exocytosis; positive regulation of osteoclast differentiation; metabolic process; cytokine and chemokine mediated signaling pathway; chemotaxis; cellular calcium ion homeostasis; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of bone mineralization; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; cell-cell signaling; calcium ion transport; response to wounding; dendritic cell chemotaxis; immune response; cell adhesion; inflammatory response; positive regulation of calcium ion transport
Research Articles on CCR1
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Products associated with anti-CCR1 antibody
Pathways associated with anti-CCR1 antibody
Diseases associated with anti-CCR1 antibody
Organs/Tissues associated with anti-CCR1 antibody
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