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anti-CCR4 antibody :: Rabbit CCR4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241421
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CCR4, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human CCR4

 Product Synonym Names    Anti-CCR4 Antibody (C-Terminus) IHC-plus; CCR4; C-C chemokine receptor type 4; CD194; CD194 antigen; C-C CKR-4; Chemr13; CKR-4; CC chemokine receptor 4; CC-CKR-4; CCR-4; HGCN:14099; C-c chemokine receptor 4; Chemokine (C-C) receptor 4; CKR4; CMKBR4; K5-5; Human CCR4
 Product Gene Name   

anti-CCR4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604836
 3D Structure    ModBase 3D Structure for P51679
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gibbon, Gorilla, Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
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 Specificity    Human CCR4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 16 amino acid peptide from C-terminal cytoplasmic domain of human CCR4. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset (100%); Monkey, Elephant (94%); Hamster (88%); Dog, Panda, Horse (81%).
 Immunogen Type    Synthetic peptide
 Immunogen    CCR4 antibody was raised against synthetic 16 amino acid peptide from C-terminal cytoplasmic domain of human CCR4. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset (100%); Monkey, Elephant (94%); Hamster (88%); Dog, Panda, Horse (81%).
 Antigen Modification    C-Terminus
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-CCR4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CCR4 antibody

   CCR4, a Chemokine Receptor, mediates inflammatory responses and HIV-1 infections. It binds beta-family chemokines (CC motif) such as TARC (thymus and activation-regulated chemokine) and MDC (macrophage-derived chemokine).
 Product Categories/Family for anti-CCR4 antibody    Family: GPCR
Subfamily: Chemokine
 Applications Tested/Suitable for anti-CCR4 antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-CCR4 antibody    ELISA, IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-CCR4 antibody    Anti-CCR4 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-CCR4 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CCR4. It may not necessarily be applicable to this product.
 NCBI GI #    5031627
 NCBI GeneID    1233
 NCBI Accession #    NP_005499.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005508.4 [Other Products]
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 UniProt Primary Accession #    P51679 [Other Products]
 UniProt Secondary Accession #    Q9ULY6; Q9ULY7 [Other Products]
 UniProt Related Accession #    P51679 [Other Products]
 Molecular Weight    41,403 Da
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 NCBI Official Full Name    C-C chemokine receptor type 4
 NCBI Official Synonym Full Names    chemokine (C-C motif) receptor 4
 NCBI Official Symbol    CCR4 [Similar Products]
 NCBI Official Synonym Symbols   
CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099
[Similar Products]
 NCBI Protein Information    C-C chemokine receptor type 4; CCR-4; C-C CKR-4; chemokine (C-C) receptor 4
 UniProt Protein Name    C-C chemokine receptor type 4
 UniProt Synonym Protein Names   
K5-5; CD_antigen: CD194
 Protein Family    C-C chemokine receptor
 UniProt Gene Name    CCR4 [Similar Products]
 UniProt Synonym Gene Names    CMKBR4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4 [Similar Products]
 UniProt Entry Name    CCR4_HUMAN
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 NCBI Summary for CCR4    The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CCR4    CCR4: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol- calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Motility/polarity/chemotaxis; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p24

Cellular Component: cell soma; integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity

Biological Process: response to antibiotic; G-protein coupled receptor protein signaling pathway; response to radiation; elevation of cytosolic calcium ion concentration; positive regulation of positive chemotaxis; response to bacterium; neuron migration; immune response; inflammatory response; chemotaxis; tolerance induction
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 Research Articles on CCR4    1. CCR4 has a role in tumor aggressive behavior in renal cell carcinoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CCR4 antibodyPathways associated with anti-CCR4 antibody
 Reference Product  PubMed Publications
 CCL17 antibody  >246 publications with CCR4 and CCL17
 CCL22 antibody  >223 publications with CCR4 and CCL22
 CCL5 antibody  >89 publications with CCR4 and CCL5
 CCL3 antibody  >46 publications with CCR4 and CCL3
 CXCL12 antibody  >42 publications with CCR4 and CXCL12
 CCL27 antibody  >20 publications with CCR4 and CCL27
 CCL13 antibody  >10 publications with CCR4 and CCL13
 CCL26 antibody  >8 publications with CCR4 and CCL26
 ADRBK1 antibody  >2 publications with CCR4 and ADRBK1
 ADRBK2 antibody  >1 publications with CCR4 and ADRBK2
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
Diseases associated with anti-CCR4 antibodyOrgans/Tissues associated with anti-CCR4 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >275 publications with CCR4 and Inflammation
 Lung Diseases Antibodies  >136 publications with CCR4 and Lung Diseases
 Necrosis Antibodies  >82 publications with CCR4 and Necrosis
 Carcinoma Antibodies  >38 publications with CCR4 and Carcinoma
 Drug Hypersensitivity Antibodies  >37 publications with CCR4 and Drug Hypersensitivity
 Fibrosis Antibodies  >30 publications with CCR4 and Fibrosis
 Liver Diseases Antibodies  >21 publications with CCR4 and Liver Diseases
 Neoplasms, Experimental Antibodies  >20 publications with CCR4 and Neoplasms, Experimental
 Heart Diseases Antibodies  >19 publications with CCR4 and Heart Diseases
 Lung Neoplasms Antibodies  >16 publications with CCR4 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >849 publications with CCR4 and Blood
 Thymus Antibodies  >157 publications with CCR4 and Thymus
 Lung Antibodies  >147 publications with CCR4 and Lung
 Brain Antibodies  >34 publications with CCR4 and Brain
 Adipose Tissue Antibodies  >8 publications with CCR4 and Adipose Tissue
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