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anti-CCR5 antibody :: Rabbit CCR5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS540460
Unit / Price
0.1 mg Affinity-Purified  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CCR5, Polyclonal Antibody

 Also Known As   

CCR5 Antibody

 Product Synonym Names    AM4 7; CCCKR 5; CD 195; CHEMR13; HIV 1 Fusion Coreceptor; IDDM22; MIP-1 alpha receptor antibody
 Product Gene Name   

anti-CCR5 antibody

[Similar Products]
 Matching Pairs    Antibody: CCR5 (MBS540460)
Positive Control: CCR5 (MBS542609)
 Antibody/Peptide Pairs    CCR5 peptide (MBS542653) is used for blocking the activity of CCR5 antibody (MBS540460)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601373
 3D Structure    ModBase 3D Structure for P51681
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Monkey, Rat
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 Form/Format    Affinity Purified
 Concentration    0.64-0.70 ug/ul in antibody stabilization buffer (lot specific)
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 Immunogen    Synthetic peptide taken within amino acid region 1-50 on human CCR5 protein.
 Expression    Spleen, Thymus, myeloid cell line THP-1, promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Lesser expressed in peripheral blood leukocytes, small intestine and ovary and lung.
 Molecular Function    actin binding; C-C chemokin binding; GPCR; Receptor; Transducer; Host-virus interaction
 Structure    Interacts with PRAF2, HIV-1 surface protein gp120. Glycosylation on Ser-6 is required for binding with CCL4.
 Subcellular Location    Cell membrane; Mulipass membrane protein.
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-CCR5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CCR5 antibody

   Affinity Purified Chemokine receptor type 5 Antibody
Receptor for several inflammatory C-C chemokines. May play a role in control of granulocytic lineage proliferation or differentiation.
 Product Categories/Family for anti-CCR5 antibody    Primary Antibodies; Neuroscience; Neurodegenerative Disease; Alzheimer's Research; CCR5 Antibody
 Applications Tested/Suitable for anti-CCR5 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-CCR5 antibody    Dot Blot: 1:10,000
ELISA: 1:10,000
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:500
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 Western Blot (WB) of anti-CCR5 antibody    anti-CCR5 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CCR5 antibody    anti-CCR5 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CCR5. It may not necessarily be applicable to this product.
 NCBI GI #    2305158
 NCBI GeneID    1234
 NCBI Accession #    AAB65720.1 [Other Products]
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 UniProt Primary Accession #    P51681 [Other Products]
 UniProt Secondary Accession #    O14692; O14693; O14695; O14696; O14697; O14698; O14699; O14700; O14701; O14702; O14703 [Other Products]
 UniProt Related Accession #    P51681 [Other Products]
 Molecular Weight    40,524 Da
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 NCBI Official Full Name    CCR5 receptor, partial
 NCBI Official Synonym Full Names    C-C motif chemokine receptor 5 (gene/pseudogene)
 NCBI Official Symbol    CCR5 [Similar Products]
 NCBI Official Synonym Symbols   
CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5
[Similar Products]
 NCBI Protein Information    C-C chemokine receptor type 5
 UniProt Protein Name    C-C chemokine receptor type 5
 UniProt Synonym Protein Names   
CHEMR13; HIV-1 fusion coreceptor; CD_antigen: CD195
 Protein Family    C-C chemokine receptor
 UniProt Gene Name    CCR5 [Similar Products]
 UniProt Synonym Gene Names    CMKBR5; C-C CKR-5; CC-CKR-5; CCR-5; CCR5 [Similar Products]
 UniProt Entry Name    CCR5_HUMAN
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 NCBI Summary for CCR5    This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]
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 UniProt Comments for CCR5    CCR5: a 7-transmembrane G-linked receptor for a number of inflammatory C-C type chemokines including MIP-1-alpha, MIP-1-beta and RANTES. Transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (along with CD4) for HIV-1 R5 isolates. Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding to CCL3/MIP-1alpha and CCR4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on S6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2. Variations in CCR5 are associated with resistance or susceptibility to immunodeficiency virus type 1 (resistance or susceptibility to HIV-1). Variations in CCR5 gene also influence the rate of progression to AIDS after infection. R60S variant, a naturally occurring mutation in a conserved residue in the first intracellular domain of CCR5, results in reduced amounts of the protein in the membrane and consequently may be associated with reduced susceptibility to infection by microbes that depend on these molecules as their receptors. Variations in CCR5 are associated with susceptibility to West Nile virus (WNV) infection

Protein type: GPCR, family 1; Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, GPCR; Receptor, cytokine; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cell surface; cytoplasm; endosome; external side of plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: actin binding; C-C chemokine binding; C-C chemokine receptor activity; chemokine receptor activity; coreceptor activity; phosphoinositide phospholipase C activity; protein binding; viral receptor activity

Biological Process: calcium ion transport; calcium-mediated signaling; cell surface receptor linked signal transduction; cell-cell signaling; cellular defense response; chemotaxis; dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; entry into host cell; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; MAPKKK cascade; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; viral envelope fusion with host membrane

Disease: Diabetes Mellitus, Insulin-dependent, 22; Hepatitis C Virus, Susceptibility To; West Nile Virus, Susceptibility To
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 Research Articles on CCR5    1. carriers of the CCR5-Delta32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CCR5 antibodyPathways associated with anti-CCR5 antibody
 Reference Product  PubMed Publications
 CD4 antibody  >3463 publications with CCR5 and CD4
 CXCR4 antibody  >2695 publications with CCR5 and CXCR4
 CCL5 antibody  >1100 publications with CCR5 and CCL5
 CCL4 antibody  >625 publications with CCR5 and CCL4
 CCL3 antibody  >547 publications with CCR5 and CCL3
 CCL2 antibody  >372 publications with CCR5 and CCL2
 CXCL12 antibody  >315 publications with CCR5 and CXCL12
 CCL11 antibody  >65 publications with CCR5 and CCL11
 CCL8 antibody  >45 publications with CCR5 and CCL8
 JAK2 antibody  >5 publications with CCR5 and JAK2
 Products by Pathway  Pathway Diagram
 Binding And Entry Of HIV Virion Pathway antibodies  Binding And Entry Of HIV Virion Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Early Phase Of HIV Life Cycle Pathway antibodies  Early Phase Of HIV Life Cycle Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
Diseases associated with anti-CCR5 antibodyOrgans/Tissues associated with anti-CCR5 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >965 publications with CCR5 and Inflammation
 Nervous System Diseases Antibodies  >441 publications with CCR5 and Nervous System Diseases
 Necrosis Antibodies  >308 publications with CCR5 and Necrosis
 Cardiovascular Diseases Antibodies  >250 publications with CCR5 and Cardiovascular Diseases
 Liver Diseases Antibodies  >217 publications with CCR5 and Liver Diseases
 Lung Diseases Antibodies  >204 publications with CCR5 and Lung Diseases
 Hepatitis C Antibodies  >120 publications with CCR5 and Hepatitis C
 Atherosclerosis Antibodies  >108 publications with CCR5 and Atherosclerosis
 Fibrosis Antibodies  >108 publications with CCR5 and Fibrosis
 Kidney Diseases Antibodies  >105 publications with CCR5 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4077 publications with CCR5 and Blood
 Brain Antibodies  >398 publications with CCR5 and Brain
 Lymph Node Antibodies  >285 publications with CCR5 and Lymph Node
 Kidney Antibodies  >190 publications with CCR5 and Kidney
 Thymus Antibodies  >114 publications with CCR5 and Thymus
 Muscle Antibodies  >86 publications with CCR5 and Muscle
 Eye Antibodies  >42 publications with CCR5 and Eye
 Connective Tissue Antibodies  >32 publications with CCR5 and Connective Tissue
 Pharynx Antibodies  >30 publications with CCR5 and Pharynx
 Prostate Antibodies  >28 publications with CCR5 and Prostate
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