NP_000570.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 40 kDa Predicted: 41 kDa
NCBI Official Full Name
C-C chemokine receptor type 5
NCBI Official Synonym Full Names
C-C motif chemokine receptor 5 (gene/pseudogene)
NCBI Official Synonym Symbols
CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5 [Similar Products]
NCBI Protein Information
C-C chemokine receptor type 5
UniProt Protein Name
C-C chemokine receptor type 5
UniProt Synonym Protein Names
CHEMR13; HIV-1 fusion coreceptor; CD_antigen: CD195
UniProt Synonym Gene Names
NCBI Summary for CCR5
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]
UniProt Comments for CCR5
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation.
Research Articles on CCR5
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Products associated with anti-CCR5 antibody
Pathways associated with anti-CCR5 antibody
Diseases associated with anti-CCR5 antibody
Organs/Tissues associated with anti-CCR5 antibody
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