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anti-CD109 antibody :: Rabbit anti-Human CD109 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2530288
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD109, Polyclonal Antibody

★Popular Item★
 Also Known As   

CD109 Polyclonal Antibody

 Product Synonym Names    CPAMD7; RP11-525G3.1
 Product Gene Name   

anti-CD109 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2530288 Technical Datasheet    Technical Datasheet PDF
 OMIM    608859
 3D Structure    ModBase 3D Structure for Q6YHK3
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity purification
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 Immunogen    Synthetic peptide of human CD109
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CD109 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD109 antibody

   This gene encodes a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene.
 Applications Tested/Suitable for anti-CD109 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-CD109 antibody    IHC: 1:25-1:100
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 Immunohistochemistry (IHC) of anti-CD109 antibody    Immunohistochemistry of paraffin-embedded Human liver cancer tissue using CD109 Polyclonal Antibody at dilution 1:30
anti-CD109 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CD109 antibody    Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CD109 Polyclonal Antibody at dilution 1:30
anti-CD109 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CD109. It may not necessarily be applicable to this product.
 NCBI GI #    227430303
 NCBI GeneID    135228
 NCBI Accession #    NP_001153059 [Other Products]
 NCBI GenBank Nucleotide #    NM_001159588.2 [Other Products]
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 UniProt Primary Accession #    Q6YHK3 [Other Products]
 UniProt Secondary Accession #    Q0P6K7; Q5SYA8; Q5XUM7; Q5XUM9; Q6MZI7; Q8N3A7; Q8N915; Q8TDJ2; A5YKK4; B2R948; B3KW25 [Other Products]
 UniProt Related Accession #    Q6YHK3 [Other Products]
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 NCBI Official Full Name    CD109 antigen isoform 3 preproprotein
 NCBI Official Synonym Full Names    CD109 molecule
 NCBI Official Symbol    CD109 [Similar Products]
 NCBI Official Synonym Symbols   
p180; r150; CPAMD7
[Similar Products]
 NCBI Protein Information    CD109 antigen; 150 kDa TGF-beta-1-binding protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7; Gov platelet alloantigens; activated T-cell marker CD109; platelet-specific Gov antigen
 UniProt Protein Name    CD109 antigen
 UniProt Synonym Protein Names   
150 kDa TGF-beta-1-binding protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7; Platelet-specific Gov antigen; p180; r150; CD_antigen: CD109
 Protein Family    CD109 antigen
 UniProt Gene Name    CD109 [Similar Products]
 UniProt Synonym Gene Names    CPAMD7 [Similar Products]
 UniProt Entry Name    CD109_HUMAN
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 NCBI Summary for CD109    This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
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 UniProt Comments for CD109    CD109: Modulates negatively TGFB1 signaling in keratinocytes. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 6q13

Cellular Component: extracellular space; cell surface; plasma membrane

Molecular Function: serine-type endopeptidase inhibitor activity; transforming growth factor beta binding

Biological Process: negative regulation of protein amino acid phosphorylation; hair follicle development; negative regulation of transforming growth factor beta receptor signaling pathway; regulation of keratinocyte differentiation
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 Research Articles on CD109    1. CD109 plays a critical role in non-small-cell lung cancer (NSCLC) progression, and is overexpressed in advanced NSCLC
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-CD109 antibodyOrgans/Tissues associated with anti-CD109 antibody
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >6 publications with CD109 and Lung Neoplasms
 Inflammation Antibodies  >5 publications with CD109 and Inflammation
 Lung Diseases Antibodies  >5 publications with CD109 and Lung Diseases
 Colorectal Neoplasms Antibodies  >5 publications with CD109 and Colorectal Neoplasms
 Breast Neoplasms Antibodies  >4 publications with CD109 and Breast Neoplasms
 Fibrosis Antibodies  >3 publications with CD109 and Fibrosis
 Disease Models, Animal Antibodies  >3 publications with CD109 and Disease Models, Animal
 Necrosis Antibodies  >2 publications with CD109 and Necrosis
 Hyperplasia Antibodies  >1 publications with CD109 and Hyperplasia
 Hemolysis Antibodies  >1 publications with CD109 and Hemolysis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35 publications with CD109 and Blood
 Bone Antibodies  >8 publications with CD109 and Bone
 Skin Antibodies  >7 publications with CD109 and Skin
 Lung Antibodies  >7 publications with CD109 and Lung
 Vascular Antibodies  >4 publications with CD109 and Vascular
 Liver Antibodies  >3 publications with CD109 and Liver
 Testis Antibodies  >3 publications with CD109 and Testis
 Connective Tissue Antibodies  >2 publications with CD109 and Connective Tissue
 Uterus Antibodies  >2 publications with CD109 and Uterus
 Esophagus Antibodies  >2 publications with CD109 and Esophagus
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