NP_001036189.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,742 Da
NCBI Official Full Name
poliovirus receptor-related protein 2 isoform delta
UniProt Protein Name
Poliovirus receptor-related protein 2
UniProt Synonym Protein Names
Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Nectin-2
UniProt Synonym Gene Names
UniProt Entry Name
PVRL2_HUMAN
NCBI Summary for CD112
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for CD112
nectin 2: Probable cell adhesion protein. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: focal adhesion; cell surface; plasma membrane; integral to membrane; intercellular junction; zonula adherens
Molecular Function: viral receptor activity; identical protein binding; protein binding; protein homodimerization activity; coreceptor activity; cell adhesion molecule binding
Biological Process: establishment of mitochondrion localization; acrosome formation; intercellular junction assembly and maintenance; regulation of immune response; sperm mitochondrion organization and biogenesis; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of immunoglobulin mediated immune response; spermatid nuclear differentiation; cytoskeleton organization and biogenesis; susceptibility to natural killer cell mediated cytotoxicity; virion attachment, binding of host cell surface coreceptor; positive regulation of natural killer cell mediated cytotoxicity; signal transduction; positive regulation of mast cell activation; fertilization; viral envelope fusion with host membrane; adhesion to host; cell part morphogenesis; homophilic cell adhesion; spermatid development
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Products associated with anti-CD112 antibody
Pathways associated with anti-CD112 antibody
Diseases associated with anti-CD112 antibody
Organs/Tissues associated with anti-CD112 antibody
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