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anti-KIT antibody :: Rabbit CD117 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS821960 anti-KIT antibody
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD117 (KIT), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-CD117 Antibody

 Product Synonym Names    SCFR; Mast/stem cell growth factor receptor Kit; SCFR; Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117
 Product Gene Name   

anti-KIT antibody

[Similar Products]
 Antibody/Peptide Pairs    CD117 peptide (MBS823406) is used for blocking the activity of CD117 antibody (MBS821960)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 606764
 3D Structure    ModBase 3D Structure for P10721
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Dog, Monkey, Pig
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 Specificity    Recognizes endogenous levels of CD117 protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD117. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-KIT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KIT antibody

   Rabbit polyclonal antibody to CD117
 Applications Tested/Suitable for anti-KIT antibody   

Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-KIT antibody    WB (1/500 - 1/1000), IP (1/10 - 1/100)
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 Western Blot (WB) of anti-KIT antibody    anti-KIT antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for KIT. It may not necessarily be applicable to this product.
 NCBI GI #    4557695
 NCBI GeneID    3815
 NCBI Accession #    NP_000213.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000222.2 [Other Products]
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 UniProt Primary Accession #    P10721 [Other Products]
 UniProt Secondary Accession #    Q6IQ28; Q99662; Q9UM99; B5A956; D5LXN2; D5M931; F5H8F8 [Other Products]
 UniProt Related Accession #    P10721 [Other Products]
 Molecular Weight    46,658 Da
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 NCBI Official Full Name    mast/stem cell growth factor receptor Kit isoform 1
 NCBI Official Synonym Full Names    v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
 NCBI Official Symbol    KIT [Similar Products]
 NCBI Official Synonym Symbols   
PBT; SCFR; C-Kit; CD117
[Similar Products]
 NCBI Protein Information    mast/stem cell growth factor receptor Kit; p145 c-kit; proto-oncogene c-Kit; piebald trait protein; soluble KIT variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
 UniProt Protein Name    Mast/stem cell growth factor receptor Kit
 UniProt Synonym Protein Names   
Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD_antigen: CD117
 Protein Family    Mast/stem cell growth factor receptor
 UniProt Gene Name    KIT [Similar Products]
 UniProt Synonym Gene Names    SCFR; SCFR; PBT [Similar Products]
 UniProt Entry Name    KIT_HUMAN
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 NCBI Summary for KIT    This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KIT    Kit: a receptor tyrosine kinase and a member of the subfamily that includes PDGF, CSF-1 and FLT-3/flk-2 receptors. Receptor for stem cell factor. Plays a critical role in hematopoietic stem cell, mast cell, melanocyte and germ cell development. Ligand binding induces autophosphorylation, dimerization and activation, leading to the recruitment and phosphorylation of downstream SH2-containing signaling components including PLC-gamma, PI3 kinase p85, SHP2 and CrkL, linking c-Kit to various cell signaling pathways. Molecular lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders, while mutations that constitutively activate c-Kit can lead to hyperplasia and tumorigenesis. Activating mutations cause >90% of gastrointestinal stromal tumors (GIST); successfully treated with inhibitors Gleevec (imatinib, Glivec) and Sutent (Sutinib, SU11248). Activating mutations also induce mastocytosis. Autocrine/paracrine stimulation may drive some lung and other tumors. Loss of expression associated with melanoma progression. Familial loss of function mutations cause piebaldism, with defects in hair and skin pigmentation due to lack of melanocytes.

Protein type: Oncoprotein; Membrane protein, integral; Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; PDGFR family

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: extracellular space; internal side of plasma membrane; mast cell granule; acrosome; integral to membrane; plasma membrane; intercellular junction; external side of plasma membrane

Molecular Function: protein binding; protein homodimerization activity; protease binding; metal ion binding; cytokine binding; protein-tyrosine kinase activity; stem cell factor receptor activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: nerve growth factor receptor signaling pathway; activation of MAPK activity; somatic stem cell maintenance; germ cell programmed cell death; positive regulation of JAK-STAT cascade; lymphoid progenitor cell differentiation; positive regulation of long-term neuronal synaptic plasticity; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of cell shape; epithelial cell proliferation; germ cell migration; erythrocyte differentiation; somatic stem cell division; T cell differentiation; fibroblast growth factor receptor signaling pathway; embryonic hemopoiesis; mast cell chemotaxis; stem cell differentiation; detection of mechanical stimulus involved in sensory perception of sound; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of tyrosine phosphorylation of Stat1 protein; immature B cell differentiation; positive regulation of transcription factor activity; regulation of pigmentation during development; glycosphingolipid metabolic process; mast cell cytokine production; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; signal transduction; ovarian follicle development; myeloid progenitor cell differentiation; positive regulation of MAPKKK cascade; melanocyte differentiation; positive regulation of cell proliferation; negative regulation of programmed cell death; visual learning; hemopoiesis; inflammatory response; positive regulation of Notch signaling pathway; lamellipodium biogenesis; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; dendritic cell cytokine production; cytokine and chemokine mediated signaling pathway; male gonad development; stem cell maintenance; positive regulation of phosphoinositide 3-kinase activity; mast cell degranulation; regulation of cell proliferation; positive regulation of pseudopodium formation; gut development; positive regulation of tyrosine phosphorylation of Stat5 protein; pigmentation; actin cytoskeleton reorganization; innate immune response; spermatogenesis; spermatid development; positive regulation of cell migration

Disease: Gastrointestinal Stromal Tumor; Mast Cell Disease; Piebald Trait; Testicular Germ Cell Tumor
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 Research Articles on KIT    1. We herein report a case of familial systemic mastocytosis with the rare KIT K509I germ line mutation affecting two family members: mother and daughter.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KIT antibodyPathways associated with anti-KIT antibody
 Reference Product  PubMed Publications
 KITLG antibody  >3739 publications with KIT and KITLG
 JAK2 antibody  >133 publications with KIT and JAK2
 CBL antibody  >56 publications with KIT and CBL
 GRB2 antibody  >39 publications with KIT and GRB2
 PTPN11 antibody  >33 publications with KIT and PTPN11
 TEC antibody  >30 publications with KIT and TEC
 PTPN6 antibody  >23 publications with KIT and PTPN6
 GRB7 antibody  >8 publications with KIT and GRB7
 PIK3R1 antibody  >4 publications with KIT and PIK3R1
 SOCS6 antibody  >2 publications with KIT and SOCS6
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
Diseases associated with anti-KIT antibodyOrgans/Tissues associated with anti-KIT antibody
 Disease Name  Pubmed Publications
 Gastrointestinal Stromal Tumors Antibodies  >2232 publications with KIT and Gastrointestinal Stromal Tumors
 Nervous System Diseases Antibodies  >1282 publications with KIT and Nervous System Diseases
 Liver Diseases Antibodies  >1256 publications with KIT and Liver Diseases
 Inflammation Antibodies  >1249 publications with KIT and Inflammation
 Lung Diseases Antibodies  >1156 publications with KIT and Lung Diseases
 Adenocarcinoma Antibodies  >1126 publications with KIT and Adenocarcinoma
 Necrosis Antibodies  >1091 publications with KIT and Necrosis
 Leukemia, Myeloid, Acute Antibodies  >868 publications with KIT and Leukemia, Myeloid, Acute
 Heart Diseases Antibodies  >818 publications with KIT and Heart Diseases
 Breast Neoplasms Antibodies  >683 publications with KIT and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2196 publications with KIT and Muscle
 Liver Antibodies  >2043 publications with KIT and Liver
 Skin Antibodies  >1478 publications with KIT and Skin
 Lung Antibodies  >1427 publications with KIT and Lung
 Heart Antibodies  >1270 publications with KIT and Heart
 Intestine Antibodies  >1108 publications with KIT and Intestine
 Kidney Antibodies  >1007 publications with KIT and Kidney
 Brain Antibodies  >997 publications with KIT and Brain
 Nerve Antibodies  >650 publications with KIT and Nerve
 Spleen Antibodies  >626 publications with KIT and Spleen
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