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anti-ITGAL antibody :: Goat CD11A/integrin alpha L Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421988
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD11A/integrin alpha L (ITGAL), Polyclonal Antibody

 Also Known As   

Goat anti-CD11A/integrin alpha L Antibody

 Product Synonym Names    ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide); CD11A; LFA-1; LFA1A; LFA-1 alpha; antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide; integrin alpha L; integrin g; ITGAL antibody; integrin; alpha L (antigen CD11A (p180); lymphocyte function-associated antigen 1 antibody; alpha polypeptide) antibody; CD11A antibody; LFA-1 antibody; LFA1A antibody; LFA-1 alpha antibody; antigen CD11A (p180); lymphocyte function-associated antigen 1; alpha polypeptide antibody; integrin alpha L antibody; integrin gene promoter antibody; lymphocyte function-associated antigen 1 antibody; Integrin alpha L; CD11A / integrin alpha L
 Product Gene Name   

anti-ITGAL antibody

[Similar Products]
 Product Synonym Gene Name    CD11A [Similar Products]
 Antibody/Peptide Pairs    CD11A / integrin alpha L peptide (MBS426430) is used for blocking the activity of CD11A/integrin alpha L antibody (MBS421988)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    YQVRIQPSIH DHN
 OMIM    153370
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-YQVRIQPSIHDHN, from the internal region of the protein sequence according to NP_002200.2; NP_001107852.1.
 Epitope    Internal region
 Note    This antibody is expected to recognize both reported isoforms (NP_002200.2; NP_001107852.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ITGAL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ITGAL antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ITGAL antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Immunohistochemistry: In paraffin embedded Human Liver shows selected staining of cells within aggregated splenocytes of the white pulp. Recommended concentration, 4-6ug/ml.
Western Blot: Approx 200kDa band observed in Human Spleen and Tonsil lysates (calculated MW of 129kDa according to NP_002200.2). The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources. Recommended concentration: 0.5-2ug/ml.
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 Western Blot (WB) of anti-ITGAL antibody    (0.5ug/ml) staining of Human Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ITGAL antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ITGAL antibody    (3.8ug/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-ITGAL antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ITGAL. It may not necessarily be applicable to this product.
 NCBI GI #    167466215
 NCBI GeneID    3683
 NCBI Accession #    NP_002200.2 [Other Products]
 NCBI Related Accession #    NP_001107852.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002209.2 [Other Products]
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 UniProt Secondary Accession #    O43746; Q45H73; Q96HB1; Q9UBC8 [Other Products]
 UniProt Related Accession #    P20701 [Other Products]
 Molecular Weight    119,224 Da
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 NCBI Official Full Name    integrin alpha-L isoform a
 NCBI Official Synonym Full Names    integrin subunit alpha L
 NCBI Official Symbol    ITGAL [Similar Products]
 NCBI Official Synonym Symbols   
CD11A; LFA-1; LFA1A
[Similar Products]
 NCBI Protein Information    integrin alpha-L
 UniProt Protein Name    Integrin alpha-L
 UniProt Synonym Protein Names   
CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD_antigen: CD11a
 Protein Family    Integrin
 UniProt Gene Name    ITGAL [Similar Products]
 UniProt Synonym Gene Names    CD11A; LFA-1A [Similar Products]
 UniProt Entry Name    ITAL_HUMAN
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 NCBI Summary for ITGAL    ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ITGAL    ITGAL: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Belongs to the integrin alpha chain family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cell surface; integrin complex; membrane; plasma membrane

Molecular Function: cell adhesion molecule binding; ICAM-3 receptor activity; metal ion binding; protein binding; protein complex binding; protein heterodimerization activity

Biological Process: cell adhesion; cell motility; cell-matrix adhesion; extracellular matrix organization and biogenesis; heterophilic cell adhesion; inflammatory response; integrin-mediated signaling pathway; leukocyte adhesion; leukocyte migration; receptor clustering; regulation of immune response; signal transduction; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
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 Research Articles on ITGAL    1. beta2 integrins-mediated chemosensory adhesion and migration of polymorphonuclear leukocytes on the vascular graft surface, bacterial cellulose.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ITGAL antibodyPathways associated with anti-ITGAL antibody
 Reference Product  PubMed Publications
 ITGB2 antibody  >12 publications with ITGAL and ITGB2
 ICAM1 antibody  >7 publications with ITGAL and ICAM1
 ITGB1 antibody  >3 publications with ITGAL and ITGB1
 ITGB3 antibody  >2 publications with ITGAL and ITGB3
 CD8A antibody  >2 publications with ITGAL and CD8A
 ICAM2 antibody  >1 publications with ITGAL and ICAM2
 ICAM3 antibody  >1 publications with ITGAL and ICAM3
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
Diseases associated with anti-ITGAL antibodyOrgans/Tissues associated with anti-ITGAL antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >254 publications with ITGAL and Inflammation
 Necrosis Antibodies  >220 publications with ITGAL and Necrosis
 Lung Diseases Antibodies  >71 publications with ITGAL and Lung Diseases
 Carcinoma Antibodies  >31 publications with ITGAL and Carcinoma
 Heart Diseases Antibodies  >27 publications with ITGAL and Heart Diseases
 Kidney Diseases Antibodies  >25 publications with ITGAL and Kidney Diseases
 Atherosclerosis Antibodies  >25 publications with ITGAL and Atherosclerosis
 Lung Injury Antibodies  >22 publications with ITGAL and Lung Injury
 Colitis Antibodies  >21 publications with ITGAL and Colitis
 Fibrosis Antibodies  >16 publications with ITGAL and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1589 publications with ITGAL and Blood
 Bone Marrow Antibodies  >185 publications with ITGAL and Bone Marrow
 Lung Antibodies  >121 publications with ITGAL and Lung
 Lymph Antibodies  >87 publications with ITGAL and Lymph
 Lymph Node Antibodies  >79 publications with ITGAL and Lymph Node
 Spleen Antibodies  >76 publications with ITGAL and Spleen
 Intestine Antibodies  >53 publications with ITGAL and Intestine
 Brain Antibodies  >51 publications with ITGAL and Brain
 Liver Antibodies  >49 publications with ITGAL and Liver
 Kidney Antibodies  >49 publications with ITGAL and Kidney
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