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anti-CD136 (RON) antibody :: Rabbit CD136 (RON) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS462021
Testing Data
Unit / Price
0.1 mg  /  $265 +1 FREE 8GB USB
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 Product Name   

CD136 (RON) (CD136 (RON)), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti CD136 antibody

 Product Synonym Names    Rabbit anti-CD136; Recepteur d’origine nantais (RON); Macrophage-Stimulating 1 Receptor (MST1R).
 Product Gene Name   

anti-CD136 (RON) antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Rat, Mouse
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 Specificity    This antibody recognizes ~175 kDa of human LRP5 protein. It also reacts with mouse and rat. The other species are not tested.
 Purity/Purification    The Rabbit IgG is purified by Site-specific Epitope Affinity Purification.
 Form/Format    This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
 Concentration    Size: 100 ug/200 ul (lot specific)
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 Antigen Preparation    A synthetic peptide corresponding to the human CD136 at internal domain. This sequence is identical to mouse or rat origin.
 Positive Control    CD136 transfected HEK293
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 Preparation and Storage    The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycle
 Other Notes    Small volumes of anti-CD136 (RON) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD136 (RON) antibody

   CD136, a transmembrane receptor tyrosine kinase, also known as Macrophage stimulating 1 receptor (MST1R) and RON (Recepteur d'origine nantais), is a member of the MET proto-oncogene family (63% homology), and is the receptor for macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. Binding of MSP to CD136 stimulates tyrosine phosphorylation on Tyr 1238 and Tyr 1239. This phosphorylation leads to a upregulation of CD136 catalytic activity and subsequent activation of downstream signaling molecules. In addition, CD136 contains putative autophosphorylation sites on Tyr 1353 and Tyr 1360. RON mediates multiple signaling cascades, such as MAPK, PI3K/AKT, FAK pathways. CD136 activation can also significantly increase C-Src activity. CD136 is a disulfide-linked 180kD heterodimer composed of a 35kD alpha chain and a 150kD beta chain, and is mainly expressed in cells of epithelial origin. CD136 is thought to play a role in early embryonic development and in the inflammatory response as well as implicated in the progression and metastasis of tumors including those of the breast and colon.
 Applications Tested/Suitable for anti-CD136 (RON) antibody   

ELISA, Western Blot, Immunohistochemistry

 Application Notes for anti-CD136 (RON) antibody    Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
Immunohistochemistry: 2-5 ug/ml
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 Testing Data of anti-CD136 (RON) antibody    anti-CD136 (RON) antibody Testing Data image
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 Molecular Weight    185 kDa
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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