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anti-CD14 antibody :: Goat CD14 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421195
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD14, Polyclonal Antibody

 Also Known As   

Goat anti-CD14 Antibody

 Product Synonym Names    CD14; CD14 antigen; HGNC: 1628; CD14 antibody; CD14 antigen antibody; HGNC: 1628 antibody
 Product Gene Name   

anti-CD14 antibody

[Similar Products]
 Product Synonym Gene Name    CD14 [Similar Products]
 Antibody/Peptide Pairs    CD14 peptide (MBS425946) is used for blocking the activity of CD14 antibody (MBS421195)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KRVDADADPR QYAD
 OMIM    158120
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-KRVDADADPRQYAD, from the internal region of the protein sequence according to NP_000582.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CD14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CD14 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CD14 antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Immunohistochemistry: In paraffin embedded Human Spleen shows strong clustered staining in some splenocytes. Recommended concentration, 4-6ug/ml.
Western Blot: Approx 55kDa band observed in Human Lung, Lymph Node and Tonsil lysates (calculated MW of 40.1kDa according to NP_000582.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Funda et al, Infect Immun.2001 Jun;69(6): 3772-81; PMID: 11349042). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-CD14 antibody    (1ug/ml) staining of Human Lymph Node lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-CD14 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CD14 antibody    Staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-CD14 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CD14. It may not necessarily be applicable to this product.
 NCBI GI #    4557417
 NCBI GeneID    929
 NCBI Accession #    NP_000582.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000591.3 [Other Products]
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 UniProt Secondary Accession #    Q53XT5; Q96FR6; Q96L99; Q9UNS3 [Other Products]
 UniProt Related Accession #    P08571 [Other Products]
 Molecular Weight    40,076 Da
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 NCBI Official Full Name    monocyte differentiation antigen CD14
 NCBI Official Synonym Full Names    CD14 molecule
 NCBI Official Symbol    CD14 [Similar Products]
 NCBI Protein Information    monocyte differentiation antigen CD14
 UniProt Protein Name    Monocyte differentiation antigen CD14
 UniProt Synonym Protein Names   
Myeloid cell-specific leucine-rich glycoprotein; CD_antigen: CD14
 Protein Family    Monocyte differentiation antigen
 UniProt Gene Name    CD14 [Similar Products]
 UniProt Entry Name    CD14_HUMAN
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 NCBI Summary for CD14    The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]
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 UniProt Comments for CD14    CD14: Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: anchored to external side of plasma membrane; endosome membrane; extracellular region; extracellular space; Golgi apparatus; lipid raft; lipopolysaccharide receptor complex; plasma membrane

Molecular Function: lipopolysaccharide binding; opsonin receptor activity; peptidoglycan receptor activity; protein binding

Biological Process: apoptosis; cell surface receptor linked signal transduction; I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; lipopolysaccharide-mediated signaling pathway; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of MyD88-independent toll-like receptor signaling pathway; phagocytosis; positive regulation of cytokine secretion; positive regulation of endocytosis; positive regulation of interferon type I production; positive regulation of interferon-gamma production; positive regulation of tumor necrosis factor production; receptor-mediated endocytosis; response to electrical stimulus; response to ethanol; response to heat; response to magnesium ion; toll-like receptor 4 signaling pathway
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 Research Articles on CD14    1. therapy with rituximab, cyclophosphamide and fludarabine resulted in a significant reduction in the number of non-classical CD14+CD16++ monocytes and soluble form of CD163 but upregulation of membrane-associated monocyte CD163
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Goat anti-CD14 Antibody
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 MBS2546544  Recombinant Human CD14 Protein (Fc tag)  MBS2533984  Anti-Mouse CD14 Antibody (FITC conjugated)
 MBS703387  Rat soluble cluster of differentiation 14, sCD14 ELISA Kit  MBS033122  Horse sCD14 ELISA Kit
 MBS9415034  CD14 Monoclonal Antibody  MBS8247747  CD144 Blocking Peptide
 MBS7241372  Bovine CD14  ELISA Kit  MBS767662  CD147 Rabbit Polyclonal
 MBS014602  Hamster Cd147/Emmprin ELISA Kit  MBS670375  Mouse Anti-Human CD14-APC/CY5.5
Products associated with anti-CD14 antibodyPathways associated with anti-CD14 antibody
 Reference Product  PubMed Publications
 TLR4 antibody  >1570 publications with CD14 and TLR4
 TLR2 antibody  >808 publications with CD14 and TLR2
 LBP antibody  >457 publications with CD14 and LBP
 MYD88 antibody  >287 publications with CD14 and MYD88
 CD36 antibody  >215 publications with CD14 and CD36
 LY96 antibody  >156 publications with CD14 and LY96
 TLR1 antibody  >107 publications with CD14 and TLR1
 TLR6 antibody  >68 publications with CD14 and TLR6
 ITGAM antibody  >45 publications with CD14 and ITGAM
 ITGB2 antibody  >3 publications with CD14 and ITGB2
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Caspase Activation Via Extrinsic Apoptotic Signalig Pathway antibodies  Caspase Activation Via Extrinsic Apoptotic Signalig Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With The TLR Signaling Cascade Pathway antibodies  Diseases Associated With The TLR Signaling Cascade Pathway Diagram
 Diseases Of Immune System Pathway antibodies  Diseases Of Immune System Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
Diseases associated with anti-CD14 antibodyOrgans/Tissues associated with anti-CD14 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2660 publications with CD14 and Inflammation
 Necrosis Antibodies  >2427 publications with CD14 and Necrosis
 Cardiovascular Diseases Antibodies  >742 publications with CD14 and Cardiovascular Diseases
 Lung Diseases Antibodies  >581 publications with CD14 and Lung Diseases
 Nervous System Diseases Antibodies  >441 publications with CD14 and Nervous System Diseases
 Liver Diseases Antibodies  >402 publications with CD14 and Liver Diseases
 Disease Models, Animal Antibodies  >373 publications with CD14 and Disease Models, Animal
 Atherosclerosis Antibodies  >355 publications with CD14 and Atherosclerosis
 Heart Diseases Antibodies  >322 publications with CD14 and Heart Diseases
 Asthma Antibodies  >282 publications with CD14 and Asthma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8172 publications with CD14 and Blood
 Bone Antibodies  >1429 publications with CD14 and Bone
 Vascular Antibodies  >905 publications with CD14 and Vascular
 Liver Antibodies  >679 publications with CD14 and Liver
 Lung Antibodies  >638 publications with CD14 and Lung
 Kidney Antibodies  >366 publications with CD14 and Kidney
 Brain Antibodies  >343 publications with CD14 and Brain
 Heart Antibodies  >340 publications with CD14 and Heart
 Muscle Antibodies  >297 publications with CD14 and Muscle
 Intestine Antibodies  >265 publications with CD14 and Intestine
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