NP_001229796.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,517 Da
NCBI Official Full Name
killer cell immunoglobulin-like receptor 3DL2 isoform 2
NCBI Official Synonym Full Names
killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2
NCBI Official Synonym Symbols
3DL2; p140; NKAT4; CD158K; NKAT-4; NKAT4B; KIR-3DL2 [Similar Products]
NCBI Protein Information
killer cell immunoglobulin-like receptor 3DL2
UniProt Protein Name
Killer cell immunoglobulin-like receptor 3DL2
UniProt Synonym Protein Names
CD158 antigen-like family member K; MHC class I NK cell receptor; Natural killer-associated transcript 4; NKAT-4; p70 natural killer cell receptor clone CL-5; p70 NK receptor CL-5; CD_antigen: CD158k
UniProt Synonym Gene Names
NCBI Summary for CD158k
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]
UniProt Comments for CD158k
KIR3DL2: Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis. Belongs to the immunoglobulin superfamily.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component: integral to plasma membrane; plasma membrane
Biological Process: cellular defense response; regulation of immune response
Research Articles on CD158k
Precautions
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Products associated with anti-CD158k antibody
Pathways associated with anti-CD158k antibody
Diseases associated with anti-CD158k antibody
Organs/Tissues associated with anti-CD158k antibody
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