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anti-CD184 antibody :: Goat anti-Rat CD184 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS224039
Testing Data #1
Unit / Price
0.1 mg  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD184, Polyclonal Antibody

 Also Known As   

GOAT ANTI HUMAN CD184 (N-TERMINAL)

 Product Gene Name   

anti-CD184 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    162643
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
 Species Reactivity    Rat
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.1% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin
 Histology Positive Control Tissue    Spleen
Buffer Solution
 Antiserum Preparation    Antiserum to human CD184 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD184 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD184 antibody

   Goat anti Human CD184 antibody recognises an epitope within the N-terminal (NT) region of human CD184, otherwise known as CXCR4 (C-X-C chemokine receptor type 4), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, ubiquitously expressed in blood and tissue cells, which acts as a specific receptor for the chemokine SDF-1 (Stromal cell-derived factor 1). Interaction of CD184 with SDF-1 mediates the chemotaxis of progenitor and mature blood cells, and is critical for B- lymphopoiesis and myelopoiesis. CD184 is a major co-receptor for infection by T-cell tropic strains of HIV1, and also a primary receptor for some HIV2 isolates. Goat anti Human CD184 antibody is reported as suitable for use in immunofluorescence studies.
 Applications Tested/Suitable for anti-CD184 antibody   

ELISA (EIA), Immunohistology Paraffin, Western Blot (WB)

 Application Notes for anti-CD184 antibody    ELISA: Maximum Dilution: 1/25000;
Immunohistology - Paraffin: Maximum Dilution: 1/150;
Western Blotting: Maximum Dilution: 1/250
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 Testing Data #1 of anti-CD184 antibody    Paraffin embedded human spleen stained with Goat anti Human CD184 (N-terminal) (MBS224039)
anti-CD184 antibody Testing Data #1 image
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NCBI/Uniprot data below describe general gene information for CD184. It may not necessarily be applicable to this product.
 NCBI GI #    56790927
 NCBI GeneID    7852
 NCBI Accession #    NP_001008540.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001008540.1 [Other Products]
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 UniProt Secondary Accession #    O60835; P30991; P56438; Q53S69; Q9BXA0; Q9UKN2; B2R5N0 [Other Products]
 UniProt Related Accession #    P61073 [Other Products]
 Molecular Weight    40,221 Da
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 NCBI Official Full Name    C-X-C chemokine receptor type 4 isoform a
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) receptor 4
 NCBI Official Symbol    CXCR4 [Similar Products]
 NCBI Official Synonym Symbols   
FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; D2S201E
[Similar Products]
 NCBI Protein Information    C-X-C chemokine receptor type 4; CD184 antigen; LPS-associated protein 3; SDF-1 receptor; fusin; leukocyte-derived seven transmembrane domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; stromal cell-derived factor 1 receptor
 UniProt Protein Name    C-X-C chemokine receptor type 4
 UniProt Synonym Protein Names   
FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; Lipopolysaccharide-associated protein 3; LAP-3; LPS-associated protein 3; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD_antigen: CD184
 UniProt Gene Name    CXCR4 [Similar Products]
 UniProt Synonym Gene Names    CXC-R4; CXCR-4; LESTR; LAP-3; LPS-associated protein 3; SDF-1 receptor [Similar Products]
 UniProt Entry Name    CXCR4_HUMAN
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 NCBI Summary for CD184    This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD184    CXCR4: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Monomer. Can form dimers. Interacts with CD164. Interacts with HIV-1 surface protein gp120 and Tat. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with human cytomegalovirus/HHV- 5 protein UL78. Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q21

Cellular Component: growth cone; cell surface; lysosome; early endosome; cytoplasm; cytoplasmic membrane-bound vesicle; leading edge; late endosome; integral to membrane; plasma membrane; intercellular junction; cytoplasmic vesicle; external side of plasma membrane

Molecular Function: G-protein coupled receptor activity; viral receptor activity; ubiquitin binding; protein binding; cytokine binding; ubiquitin protein ligase binding; myosin light chain binding; coreceptor activity; actin binding; C-X-C chemokine receptor activity

Biological Process: entry of virus into host cell; regulation of chemotaxis; neutrophil activation; viral reproduction; activation of MAPK activity; apoptosis; response to virus; neuron migration; calcium-mediated signaling; motor axon guidance; regulation of cell migration; germ cell development; patterning of blood vessels; T cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; ameboidal cell migration; germ cell migration; myelin maintenance; response to hypoxia; dendritic cell chemotaxis; entry into host cell; positive regulation of oligodendrocyte differentiation; brain development; inflammatory response

Disease: Whim Syndrome
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 Research Articles on CD184    1. Data show that the CXC chemokine receptor 4 (CXCR4) antagonist AMD 3100 disrupted the stromal cell-derived factor 1 (SDF-1alpha)/CXCR4 axis and decreases platelet-derived growth factor B (PDGF-B) protein expression in vivo in two xenograft Ewing tumor models.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD184 antibodyPathways associated with anti-CD184 antibody
 Reference Product  PubMed Publications
 CXCL12 antibody  >3342 publications with CD184 and CXCL12
 CD4 antibody  >2112 publications with CD184 and CD4
 CCL2 antibody  >150 publications with CD184 and CCL2
 PTPRC antibody  >124 publications with CD184 and PTPRC
 HIF1A antibody  >98 publications with CD184 and HIF1A
 RAC1 antibody  >45 publications with CD184 and RAC1
 ITCH antibody  >13 publications with CD184 and ITCH
 ADRBK1 antibody  >6 publications with CD184 and ADRBK1
 SDC4 antibody  >5 publications with CD184 and SDC4
 UBC antibody  >4 publications with CD184 and UBC
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Binding And Entry Of HIV Virion Pathway antibodies  Binding And Entry Of HIV Virion Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with anti-CD184 antibodyOrgans/Tissues associated with anti-CD184 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >661 publications with CD184 and Inflammation
 Neoplasm Metastasis Antibodies  >625 publications with CD184 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >486 publications with CD184 and Disease Models, Animal
 Nervous System Diseases Antibodies  >449 publications with CD184 and Nervous System Diseases
 Breast Neoplasms Antibodies  >399 publications with CD184 and Breast Neoplasms
 Lung Diseases Antibodies  >321 publications with CD184 and Lung Diseases
 Necrosis Antibodies  >295 publications with CD184 and Necrosis
 Lung Neoplasms Antibodies  >238 publications with CD184 and Lung Neoplasms
 Heart Diseases Antibodies  >222 publications with CD184 and Heart Diseases
 Neoplasms, Experimental Antibodies  >217 publications with CD184 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3727 publications with CD184 and Blood
 Bone Antibodies  >1624 publications with CD184 and Bone
 Bone Marrow Antibodies  >1432 publications with CD184 and Bone Marrow
 Vascular Antibodies  >1011 publications with CD184 and Vascular
 Brain Antibodies  >679 publications with CD184 and Brain
 Lung Antibodies  >496 publications with CD184 and Lung
 Lymph Node Antibodies  >424 publications with CD184 and Lymph Node
 Liver Antibodies  >423 publications with CD184 and Liver
 Lymph Antibodies  >415 publications with CD184 and Lymph
 Muscle Antibodies  >338 publications with CD184 and Muscle
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