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anti-CD19 antibody :: Rabbit CD19 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS301733
Immunohistochemistry (IHC)
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD19, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Anti-Human CD19 Polyclonal Antibody

 Product Gene Name   

anti-CD19 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107265
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Predicted Reactivity: Bovine, Pig
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 Form/Format    0.1 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
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 Immunogen    Synthetic peptide derived from C-terminus of human CD19 protein.
 Control Tissue    Tonsil
 Cellular Localization    Membrane
 Entrez Gene Code    930
 Pathway    Stem Cell
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 Preparation and Storage    Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
 Other Notes    Small volumes of anti-CD19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD19 antibody

   CD19 is expressed in B lymphocytes and B-cell lymphoma. It may also be present on some early myeloid progenitors, particularly those of the monoblastic type. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. CD19 is negative in T lymphocytes, plasma cells, and their tumors
 Applications Tested/Suitable for anti-CD19 antibody   

Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-CD19 antibody    Immunohistochemistry Procedure
Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:200. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 10mM citrate, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 30 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system.
Immunohistochemistry Dilution: 1:200
IHC Positive Control: Tonsil
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 Immunohistochemistry (IHC) of anti-CD19 antibody    Human tonsil stained with anti-CD19 antibody
anti-CD19 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CD19. It may not necessarily be applicable to this product.
 NCBI GI #    296010921
 NCBI GeneID    930
 NCBI Accession #    NP_001171569.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001178098.1 [Other Products]
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 UniProt Secondary Accession #    Q96S68; Q9BRD6; A0N0P9; F5H635 [Other Products]
 UniProt Related Accession #    P15391 [Other Products]
 Molecular Weight    61 kDa
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 NCBI Official Full Name    B-lymphocyte antigen CD19 isoform 1
 NCBI Official Synonym Full Names    CD19 molecule
 NCBI Official Symbol    CD19 [Similar Products]
 NCBI Official Synonym Symbols   
B4; CVID3
[Similar Products]
 NCBI Protein Information    B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; T-cell surface antigen Leu-12; differentiation antigen CD19
 UniProt Protein Name    B-lymphocyte antigen CD19
 UniProt Synonym Protein Names   
B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12; CD_antigen: CD19
 Protein Family    B-lymphocyte antigen
 UniProt Gene Name    CD19 [Similar Products]
 UniProt Entry Name    CD19_HUMAN
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 NCBI Summary for CD19    Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD19    CD19: a cell surface molecule which assembles with the antigen receptor of B lymphocytes. A critical signal transduction molecule that regulates B lymphocyte development, activation, and differentiation. Ligation increases intracellular calcium levels and decreases the threshold for antigen receptor signaling. Germinal center formation is significantly reduced in CD19-deficient mice.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: protein complex; integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: receptor signaling protein activity

Biological Process: epidermal growth factor receptor signaling pathway; regulation of immune response; B cell receptor signaling pathway; fibroblast growth factor receptor signaling pathway; cell surface receptor linked signal transduction; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; cellular defense response; innate immune response; positive regulation of release of sequestered calcium ion into cytosol

Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 3
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 Research Articles on CD19    1. Suppression of innate and adaptive B cell activation pathways by antibody coengagement of FcgammaRIIb and CD19.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD19 antibodyPathways associated with anti-CD19 antibody
 Reference Product  PubMed Publications
 CD22 antibody  >605 publications with CD19 and CD22
 CD79A antibody  >150 publications with CD19 and CD79A
 CD79B antibody  >107 publications with CD19 and CD79B
 CD81 antibody  >96 publications with CD19 and CD81
 CR2 antibody  >75 publications with CD19 and CR2
 LYN antibody  >57 publications with CD19 and LYN
 SYK antibody  >48 publications with CD19 and SYK
 BTK antibody  >45 publications with CD19 and BTK
 VAV1 antibody  >13 publications with CD19 and VAV1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
Diseases associated with anti-CD19 antibodyOrgans/Tissues associated with anti-CD19 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >446 publications with CD19 and Cardiovascular Diseases
 Inflammation Antibodies  >362 publications with CD19 and Inflammation
 Respiratory Tract Diseases Antibodies  >329 publications with CD19 and Respiratory Tract Diseases
 Necrosis Antibodies  >326 publications with CD19 and Necrosis
 Death Antibodies  >265 publications with CD19 and Death
 Lung Diseases Antibodies  >209 publications with CD19 and Lung Diseases
 Liver Diseases Antibodies  >164 publications with CD19 and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >138 publications with CD19 and Cell Transformation, Neoplastic
 Respiratory Tract Infections Antibodies  >112 publications with CD19 and Respiratory Tract Infections
 Common Variable Immunodeficiency Antibodies  >91 publications with CD19 and Common Variable Immunodeficiency
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6249 publications with CD19 and Blood
 Bone Marrow Antibodies  >1742 publications with CD19 and Bone Marrow
 Spleen Antibodies  >578 publications with CD19 and Spleen
 Lymph Node Antibodies  >480 publications with CD19 and Lymph Node
 Lymph Antibodies  >430 publications with CD19 and Lymph
 Lung Antibodies  >215 publications with CD19 and Lung
 Thymus Antibodies  >175 publications with CD19 and Thymus
 Brain Antibodies  >133 publications with CD19 and Brain
 Tonsil Antibodies  >117 publications with CD19 and Tonsil
 Intestine Antibodies  >106 publications with CD19 and Intestine
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