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anti-CD19 antibody :: Rabbit anti-Human CD19 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9204578
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD19, Polyclonal Antibody

★Popular Item★
 Also Known As   

CD19 Antibody (N-term)

 Product Synonym Names    B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12; CD19; CD19
 Product Gene Name   

anti-CD19 antibody

[Similar Products]
 Antibody/Peptide Pairs    CD19 peptide (MBS9221255) is used for blocking the activity of CD19 antibody (MBS9204578)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    143-172
 OMIM    107265
 3D Structure    ModBase 3D Structure for P15391
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This CD19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-172 amino acids from the N-terminal region of human CD19.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 (lot specific)
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 Antigen Type    Synthetic Peptide
 Crown Antibody    Yes
 Antigen Source    HUMAN
 Function    Assembles with the antigen receptor ofB-lymphocytes in order to decrease thethreshold for antigen receptor-dependentstimulation.
 Cellular Location    Membrane; Single-pass type I membrane protein
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-CD19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD19 antibody

   Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. CD19 is a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
 Product Categories/Family for anti-CD19 antibody    Crown Antibodies; Cancer; Immunology; Signal Transduction
 Applications Tested/Suitable for anti-CD19 antibody   

Western Blot (WB), ELISA (EIA), Immunofluorescence (IF), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC)

 Application Notes for anti-CD19 antibody    WB~~1:1000
IF~~1:10~50
FC~~1:10~50
IHC-P~~1:10~50
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 Western Blot (WB) of anti-CD19 antibody    Western blot analysis of lysate from Ramos cell line, using CD19Antibody (N-term). MBS9204578 was diluted at 1:500. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
anti-CD19 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-CD19 antibody    CD19 Antibody (N-term) western blot analysis in Raji cell line lysates (35ug/lane).This demonstrates the CD19 antibody detected the CD19 protein (arrow).
anti-CD19 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-CD19 antibody    Western blot analysis of CD19 (arrow) using rabbit polyclonal CD19 Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CD19 gene (Lane 2) (Origene Technologies).
anti-CD19 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-CD19 antibody    Immunofluorescence analysis of CD19 Antibody (N-term) with paraffin-embedded human lymph tissue. 0.05 mg/ml primary antibody was followed by FITC-conjugated goat anti-rabbit lgG (whole molecule). FITC emits green fluorescence.Red counterstaining is PI.
anti-CD19 antibody Immunofluorescence (IF) image
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 Flow Cytometry (FC/FACS) of anti-CD19 antibody    Flow cytometric analysis of CEM cells using CD19 Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-CD19 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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 Immunohistochemistry (IHC) of anti-CD19 antibody    Formalin-fixed and paraffin-embedded human lymph reacted with CD19 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-CD19 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CD19. It may not necessarily be applicable to this product.
 NCBI GI #    296010921
 NCBI GeneID    930
 NCBI Accession #    NP_001171569.1 [Other Products]
 NCBI Related Accession #    NP_001761.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001178098.1 [Other Products]
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 UniProt Primary Accession #    P15391 [Other Products]
 UniProt Secondary Accession #    Q96S68; Q9BRD6; A0N0P9; F5H635 [Other Products]
 UniProt Related Accession #    P15391 [Other Products]
 Molecular Weight    61128
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 NCBI Official Full Name    B-lymphocyte antigen CD19 isoform 1
 NCBI Official Synonym Full Names    CD19 molecule
 NCBI Official Symbol    CD19 [Similar Products]
 NCBI Official Synonym Symbols   
B4; CVID3
[Similar Products]
 NCBI Protein Information    B-lymphocyte antigen CD19
 UniProt Protein Name    B-lymphocyte antigen CD19
 UniProt Synonym Protein Names   
B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12; CD_antigen: CD19
 Protein Family    B-lymphocyte antigen
 UniProt Gene Name    CD19 [Similar Products]
 UniProt Entry Name    CD19_HUMAN
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 NCBI Summary for CD19    Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD19    CD19: a cell surface molecule which assembles with the antigen receptor of B lymphocytes. A critical signal transduction molecule that regulates B lymphocyte development, activation, and differentiation. Ligation increases intracellular calcium levels and decreases the threshold for antigen receptor signaling. Germinal center formation is significantly reduced in CD19-deficient mice.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: protein complex; integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: receptor signaling protein activity

Biological Process: epidermal growth factor receptor signaling pathway; regulation of immune response; B cell receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; cell surface receptor linked signal transduction; nerve growth factor receptor signaling pathway; cellular defense response; innate immune response; positive regulation of release of sequestered calcium ion into cytosol

Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 3
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Product References and Citations for anti-CD19 antibody

   Deaglio,S., Blood 109 (12), 5390-5398 (2007)
Bradbury,L.E., J. Immunol. 149 (9), 2841-2850 (1992)
Kozmik,Z., Mol. Cell. Biol. 12 (6), 2662-2672 (1992)
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 Research Articles on CD19    1. propose a multilayer model of plasma cell (PC) memory in which CD19(+) and CD19(-) PC represent dynamic and static components, respectively, permitting both adaptation and stability of humoral immune protection
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD19 antibodyDiseases associated with anti-CD19 antibody
 Reference Product  PubMed Publications
 CD22 antibody  >613 publications with CD19 and CD22
 CD79A antibody  >152 publications with CD19 and CD79A
 CD79B antibody  >109 publications with CD19 and CD79B
 CD81 antibody  >102 publications with CD19 and CD81
 CR2 antibody  >76 publications with CD19 and CR2
 LYN antibody  >59 publications with CD19 and LYN
 SYK antibody  >49 publications with CD19 and SYK
 VAV1 antibody  >13 publications with CD19 and VAV1
 PIK3R1 antibody  >2 publications with CD19 and PIK3R1
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >459 publications with CD19 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >433 publications with CD19 and Vascular Diseases
 Inflammation Antibodies  >377 publications with CD19 and Inflammation
 Necrosis Antibodies  >338 publications with CD19 and Necrosis
 Neoplasms, Experimental Antibodies  >325 publications with CD19 and Neoplasms, Experimental
 Death Antibodies  >273 publications with CD19 and Death
 Lung Diseases Antibodies  >217 publications with CD19 and Lung Diseases
 Liver Diseases Antibodies  >171 publications with CD19 and Liver Diseases
 Common Variable Immunodeficiency Antibodies  >93 publications with CD19 and Common Variable Immunodeficiency
 Agammaglobulinemia Antibodies  >88 publications with CD19 and Agammaglobulinemia
Organs/Tissues associated with anti-CD19 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6398 publications with CD19 and Blood
 Bone Marrow Antibodies  >1779 publications with CD19 and Bone Marrow
 Spleen Antibodies  >590 publications with CD19 and Spleen
 Lymph Node Antibodies  >483 publications with CD19 and Lymph Node
 Lymph Antibodies  >433 publications with CD19 and Lymph
 Lung Antibodies  >218 publications with CD19 and Lung
 Thymus Antibodies  >175 publications with CD19 and Thymus
 Brain Antibodies  >143 publications with CD19 and Brain
 Tonsil Antibodies  >118 publications with CD19 and Tonsil
 Intestine Antibodies  >107 publications with CD19 and Intestine
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