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| Product Name
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CD2, Polyclonal Antibody
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| Also Known As
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CD2 Antibody BIOTIN-Conjugated
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| Product Synonym Names
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CD 2; CD2 antigen (p50), sheep red blood cell receptor; Erythrocyte receptor; FLJ46032; LFA-2; LFA-3 receptor; Ly-37; Lymphocyte function antigen 2; p50; Rosette receptor; Sheep erythrocyte receptor; T cell surface antigen CD2; T cell surface antigen T11/Leu 5 antibody
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| Product Gene Name
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[Similar Products]
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| Antibody/Peptide Pairs
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CD2 peptide (MBS542679) is used for blocking the activity of CD2 antibody (MBS541196)
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| OMIM
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186990
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| 3D Structure
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ModBase 3D Structure for P06729
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| Clonality
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Polyclonal
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| Host
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Rabbit
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| Species Reactivity
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Human, Monkey
Predicted:Mouse, Rat
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| Form/Format
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BIOTIN-Conjugated
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| Concentration
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0.50-0.75 ug/ul in antibody stabilization buffer (lot specific)
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| Immunogen
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Synthetic peptide corresponding to amino acid region 3335-351 on human T-cell surface antigen CD2 protein.
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| Determinant
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Extreme C-epitope
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| Molecular Function
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Cell adhesion
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| Structure
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Cytoplasmic domain is implicated in signaling function. Contains 1 Ig-like C2-type domain and 1 Ig-like V-type domain
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| Subcellular Location
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Membrane; Single-pass type I membrane protein.
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| Preparation and Storage
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-20 degree C for long term storage
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| Other Notes
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Small volumes of anti-CD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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BIOTIN-Conjugated T-cell surface antigen CD2 Antibody Extreme C-epitope
Interacts with lymphocyte function associated antigen and CD48/BCM1 to mediate adhesion between T-cells and other cells.
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| Applications Tested/Suitable for anti-CD2 antibody
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ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
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| Application Notes for anti-CD2 antibody
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Dot Blot: 1:10,000
ELISA: 1:10,000
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:500
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TOP
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| NCBI/Uniprot data below describe general gene information for CD2. It may not necessarily be applicable to this product. |
| NCBI GI #
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156071472
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| NCBI GeneID
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914
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| NCBI Accession #
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NP_001758
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_001767.3
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[Other Products]
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| UniProt Primary Accession #
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P06729
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[Other Products]
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| UniProt Secondary Accession #
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Q96TE5
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[Other Products]
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| UniProt Related Accession #
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P06729
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[Other Products]
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| Molecular Weight
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39,448 Da
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TOP
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| NCBI Official Full Name
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T-cell surface antigen CD2
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| NCBI Official Synonym Full Names
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CD2 molecule
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| NCBI Official Symbol
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CD2
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[Similar Products]
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| NCBI Official Synonym Symbols
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T11; SRBC; LFA-2
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[Similar Products]
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| NCBI Protein Information
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T-cell surface antigen CD2
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| UniProt Protein Name
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T-cell surface antigen CD2
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| UniProt Synonym Protein Names
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Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD_antigen: CD2
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| Protein Family
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CD2
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| UniProt Gene Name
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CD2
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[Similar Products]
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| UniProt Synonym Gene Names
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SRBC
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[Similar Products]
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| UniProt Entry Name
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CD2_HUMAN
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| NCBI Summary for CD2
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CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]
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| UniProt Comments for CD2
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CD2: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function.
Protein type: Cell surface; Membrane protein, integral; Apoptosis
Chromosomal Location of Human Ortholog: 1p13.1
Cellular Component: anchored to plasma membrane; cell surface; external side of plasma membrane; extracellular region; integral to plasma membrane; intercellular junction; internal side of plasma membrane; plasma membrane
Molecular Function: protein binding; protein homodimerization activity; receptor activity; receptor binding
Biological Process: apoptosis; cell surface receptor linked signal transduction; cell-cell adhesion; heterotypic cell-cell adhesion; leukocyte migration; lipid raft polarization; natural killer cell activation; positive regulation of myeloid dendritic cell activation; positive regulation of tumor necrosis factor production; regulation of T cell differentiation; T cell activation
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TOP
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| Research Articles on CD2
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1. the fundamental mechanism of glycosylation of human CD2 is to promote CD2-CD58 binding by conformational adjustment of CD2
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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TOP
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| Products associated with anti-CD2 antibody | Pathways associated with anti-CD2 antibody |
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| Diseases associated with anti-CD2 antibody | Organs/Tissues associated with anti-CD2 antibody |
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TOP
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Antibody 
