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anti-CD2 antibody :: Rabbit CD2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS541197 anti-CD2 antibody
Unit / Price
0.1 mg FITC  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD2, Polyclonal Antibody

 Also Known As   

CD2 Antibody FITC-Conjugated

 Product Synonym Names    CD 2; CD2 antigen (p50), sheep red blood cell receptor; Erythrocyte receptor; FLJ46032; LFA-2; LFA-3 receptor; Ly-37; Lymphocyte function antigen 2; p50; Rosette receptor; Sheep erythrocyte receptor; T cell surface antigen CD2; T cell surface antigen T11/Leu 5 antibody
 Product Gene Name   

anti-CD2 antibody

[Similar Products]
 Antibody/Peptide Pairs    CD2 peptide (MBS542679) is used for blocking the activity of CD2 antibody (MBS541197)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    186990
 3D Structure    ModBase 3D Structure for P06729
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Monkey
Predicted: Mouse, Rat
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 Form/Format    FITC-Conjugated
 Concentration    0.50-0.75 ug/ul in antibody stabilization buffer (lot specific)
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 Immunogen    Synthetic peptide corresponding to amino acid region 3335-351 on human T-cell surface antigen CD2 protein.
 Determinant    Mid-Region
 Molecular Function    Cell adhesion
 Structure    Cytoplasmic domain is implicated in signaling function. Contains 1 Ig-like C2-type domain and 1 Ig-like V-type domain
 Subcellular Location    Membrane; Single-pass type I membrane protein.
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-CD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD2 antibody

   FITC-Conjugated T-cell surface antigen CD2 Antibody Extreme C-epitope
Interacts with lymphocyte function associated antigen and CD48/BCM1 to mediate adhesion between T-cells and other cells.
 Applications Tested/Suitable for anti-CD2 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-CD2 antibody    Dot Blot: 1:10,000
ELISA: 1:10,000
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:500
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NCBI/Uniprot data below describe general gene information for CD2. It may not necessarily be applicable to this product.
 NCBI GI #    156071472
 NCBI GeneID    914
 NCBI Accession #    NP_001758 [Other Products]
 NCBI GenBank Nucleotide #    NM_001767.3 [Other Products]
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 UniProt Primary Accession #    P06729 [Other Products]
 UniProt Secondary Accession #    Q96TE5 [Other Products]
 UniProt Related Accession #    P06729 [Other Products]
 Molecular Weight    39,448 Da
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 NCBI Official Full Name    T-cell surface antigen CD2
 NCBI Official Synonym Full Names    CD2 molecule
 NCBI Official Symbol    CD2 [Similar Products]
 NCBI Official Synonym Symbols   
T11; SRBC; LFA-2
[Similar Products]
 NCBI Protein Information    T-cell surface antigen CD2
 UniProt Protein Name    T-cell surface antigen CD2
 UniProt Synonym Protein Names   
Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD_antigen: CD2
 Protein Family    CD2
 UniProt Gene Name    CD2 [Similar Products]
 UniProt Synonym Gene Names    SRBC [Similar Products]
 UniProt Entry Name    CD2_HUMAN
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 NCBI Summary for CD2    CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]
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 UniProt Comments for CD2    CD2: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function.

Protein type: Membrane protein, integral; Cell surface; Apoptosis

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: anchored to plasma membrane; cell surface; external side of plasma membrane; extracellular region; integral to plasma membrane; intercellular junction; internal side of plasma membrane; plasma membrane

Molecular Function: protein binding; protein homodimerization activity; receptor activity; receptor binding

Biological Process: apoptosis; cell surface receptor linked signal transduction; cell-cell adhesion; heterotypic cell-cell adhesion; leukocyte migration; lipid raft polarization; natural killer cell activation; positive regulation of myeloid dendritic cell activation; positive regulation of tumor necrosis factor production; regulation of T cell differentiation; T cell activation
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 Research Articles on CD2    1. the fundamental mechanism of glycosylation of human CD2 is to promote CD2-CD58 binding by conformational adjustment of CD2
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD2 antibodyPathways associated with anti-CD2 antibody
 Reference Product  PubMed Publications
 CD58 antibody  >426 publications with CD2 and CD58
 CD2AP antibody  >188 publications with CD2 and CD2AP
 CD48 antibody  >148 publications with CD2 and CD48
 LCK antibody  >80 publications with CD2 and LCK
 SH3KBP1 antibody  >19 publications with CD2 and SH3KBP1
 CD2BP2 antibody  >14 publications with CD2 and CD2BP2
 SYK antibody  >12 publications with CD2 and SYK
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-CD2 antibodyOrgans/Tissues associated with anti-CD2 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >323 publications with CD2 and Necrosis
 Inflammation Antibodies  >254 publications with CD2 and Inflammation
 Chromosome Aberrations Antibodies  >180 publications with CD2 and Chromosome Aberrations
 Kidney Diseases Antibodies  >162 publications with CD2 and Kidney Diseases
 Liver Diseases Antibodies  >134 publications with CD2 and Liver Diseases
 Skin Neoplasms Antibodies  >132 publications with CD2 and Skin Neoplasms
 Lung Diseases Antibodies  >109 publications with CD2 and Lung Diseases
 Vascular Diseases Antibodies  >108 publications with CD2 and Vascular Diseases
 Anemia Antibodies  >105 publications with CD2 and Anemia
 Cell Transformation, Neoplastic Antibodies  >97 publications with CD2 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4744 publications with CD2 and Blood
 Bone Antibodies  >796 publications with CD2 and Bone
 Muscle Antibodies  >552 publications with CD2 and Muscle
 Kidney Antibodies  >517 publications with CD2 and Kidney
 Thymus Antibodies  >442 publications with CD2 and Thymus
 Lymph Node Antibodies  >402 publications with CD2 and Lymph Node
 Heart Antibodies  >317 publications with CD2 and Heart
 Spleen Antibodies  >288 publications with CD2 and Spleen
 Intestine Antibodies  >258 publications with CD2 and Intestine
 Lung Antibodies  >193 publications with CD2 and Lung
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