NP_001758.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,448 Da
NCBI Official Full Name
T-cell surface antigen CD2
NCBI Official Synonym Full Names
CD2 molecule
NCBI Protein Information
T-cell surface antigen CD2
UniProt Protein Name
T-cell surface antigen CD2
UniProt Synonym Protein Names
Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD_antigen: CD2
UniProt Synonym Gene Names
UniProt Entry Name
CD2_HUMAN
NCBI Summary for CD2
CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]
UniProt Comments for CD2
CD2: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function.
Protein type: Membrane protein, integral; Cell surface; Apoptosis
Chromosomal Location of Human Ortholog: 1p13.1
Cellular Component: internal side of plasma membrane; cell surface; anchored to plasma membrane; integral to plasma membrane; extracellular region; plasma membrane; intercellular junction; external side of plasma membrane
Molecular Function: protein binding; protein homodimerization activity; receptor activity; receptor binding
Biological Process: heterotypic cell-cell adhesion; cell-cell adhesion; cell surface receptor linked signal transduction; T cell activation; apoptosis; natural killer cell activation; regulation of T cell differentiation; positive regulation of tumor necrosis factor production; lipid raft polarization; blood coagulation; leukocyte migration; positive regulation of myeloid dendritic cell activation
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Products associated with anti-CD2 antibody
Pathways associated with anti-CD2 antibody
Organs/Tissues associated with anti-CD2 antibody
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