NP_001276952.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,366 Da
NCBI Official Full Name
interleukin-12 receptor subunit beta-1 isoform 3
NCBI Official Synonym Full Names
interleukin 12 receptor subunit beta 1
NCBI Official Synonym Symbols
CD212; IMD30; IL12RB; IL-12R-BETA1 [Similar Products]
NCBI Protein Information
interleukin-12 receptor subunit beta-1
UniProt Protein Name
Interleukin-12 receptor subunit beta-1
UniProt Synonym Protein Names
IL-12 receptor beta component; CD_antigen: CD212
UniProt Synonym Gene Names
IL12R; IL12RB; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12RB1 [Similar Products]
UniProt Entry Name
I12R1_HUMAN
NCBI Summary for IL12RB1
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
UniProt Comments for IL12RB1
Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
Research Articles on IL12RB1
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Pathways associated with anti-IL12RB1 antibody
Diseases associated with anti-IL12RB1 antibody
Organs/Tissues associated with anti-IL12RB1 antibody
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