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anti-CD27 antibody :: Rabbit CD27 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2520573
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD27, Polyclonal Antibody

 Also Known As   

CD27 Polyclonal Antibody

 Product Synonym Names    T14; S152; Tp55; TNFRSF7; S152. LPFS2
 Product Gene Name   

anti-CD27 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    186711
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    2.8mg/mL (lot specific)
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 Immunogen    Recombinant protein of human CD27
 Calculated Molecular Weight: 29kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CD27 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD27 antibody

   The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
 Product Categories/Family for anti-CD27 antibody    Stem cells; Cancer
 Applications Tested/Suitable for anti-CD27 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CD27 antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
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 Western Blot (WB) of anti-CD27 antibody    Western Blot analysis of Raji and lovo cell using CD27 Polyclonal Antibody at dilution of 1:701
anti-CD27 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CD27 antibody    Immunohistochemistry of paraffin-embedded Human colon cancer using CD27 Polyclonal Antibody at dilution of 1:60
anti-CD27 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CD27 antibody    Immunohistochemistry of paraffin-embedded Human thyroid cancer using CD27 Polyclonal Antibody at dilution of 1:60
anti-CD27 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CD27. It may not necessarily be applicable to this product.
 NCBI GI #    4507587
 NCBI GeneID    939
 NCBI Accession #    NP_001233.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001242.4 [Other Products]
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 UniProt Secondary Accession #    B2RDZ0 [Other Products]
 UniProt Related Accession #    P26842 [Other Products]
 Molecular Weight    29,137 Da
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 NCBI Official Full Name    CD27 antigen
 NCBI Official Synonym Full Names    CD27 molecule
 NCBI Official Symbol    CD27 [Similar Products]
 NCBI Official Synonym Symbols   
T14; S152; Tp55; TNFRSF7; S152. LPFS2
[Similar Products]
 NCBI Protein Information    CD27 antigen; CD27L receptor; T cell activation antigen S152; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily, member 7
 UniProt Protein Name    CD27 antigen
 UniProt Synonym Protein Names   
CD27L receptor; T-cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7; CD_antigen: CD27
 Protein Family    CD27 antigen
 UniProt Gene Name    CD27 [Similar Products]
 UniProt Synonym Gene Names    TNFRSF7 [Similar Products]
 UniProt Entry Name    CD27_HUMAN
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 NCBI Summary for CD27    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD27    CD27: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

Protein type: Membrane protein, integral; Apoptosis; Receptor, cytokine

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: integral to plasma membrane; extracellular region; external side of plasma membrane

Molecular Function: protein binding; transmembrane receptor activity; caspase inhibitor activity

Biological Process: release of cytoplasmic sequestered NF-kappaB; response to ethanol; cell surface receptor linked signal transduction; positive regulation of JNK cascade; positive regulation of B cell differentiation; immunoglobulin mediated immune response; negative regulation of caspase activity; negative regulation of apoptosis

Disease: Lymphoproliferative Syndrome 2
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 Research Articles on CD27    1. A lower primary CD24(hi) CD27(+) CD19(+) B cells may be an immunologic aspect of new-onset SLE that may be a useful tool to evaluate lupus activity and monitor the response to therapy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD27 antibodyPathways associated with anti-CD27 antibody
 Reference Product  PubMed Publications
 CD70 antibody  >255 publications with CD27 and CD70
 CD38 antibody  >245 publications with CD27 and CD38
 CCR7 antibody  >210 publications with CD27 and CCR7
 CD5 antibody  >117 publications with CD27 and CD5
 CXCR3 antibody  >49 publications with CD27 and CXCR3
 TRAF2 antibody  >13 publications with CD27 and TRAF2
 SIVA1 antibody  >12 publications with CD27 and SIVA1
 TRAF3 antibody  >8 publications with CD27 and TRAF3
 CCR3 antibody  >5 publications with CD27 and CCR3
 CD40LG antibody  >1 publications with CD27 and CD40LG
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with anti-CD27 antibodyOrgans/Tissues associated with anti-CD27 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >898 publications with CD27 and Immune System Diseases
 Necrosis Antibodies  >429 publications with CD27 and Necrosis
 Lymphoma Antibodies  >226 publications with CD27 and Lymphoma
 Inflammation Antibodies  >169 publications with CD27 and Inflammation
 Nervous System Diseases Antibodies  >102 publications with CD27 and Nervous System Diseases
 Skin Diseases Antibodies  >91 publications with CD27 and Skin Diseases
 Neoplasms, Experimental Antibodies  >81 publications with CD27 and Neoplasms, Experimental
 Liver Diseases Antibodies  >63 publications with CD27 and Liver Diseases
 Carcinoma Antibodies  >59 publications with CD27 and Carcinoma
 Memory Disorders Antibodies  >43 publications with CD27 and Memory Disorders
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2329 publications with CD27 and Blood
 Lymph Node Antibodies  >175 publications with CD27 and Lymph Node
 Spleen Antibodies  >151 publications with CD27 and Spleen
 Lymph Antibodies  >142 publications with CD27 and Lymph
 Lung Antibodies  >90 publications with CD27 and Lung
 Kidney Antibodies  >82 publications with CD27 and Kidney
 Thymus Antibodies  >79 publications with CD27 and Thymus
 Tonsil Antibodies  >62 publications with CD27 and Tonsil
 Intestine Antibodies  >38 publications with CD27 and Intestine
 Heart Antibodies  >38 publications with CD27 and Heart
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