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anti-CD274 antibody :: Rabbit anti-Human CD274 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS127807
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD274, Polyclonal Antibody

★Popular Item★
 Also Known As   

CD274 Polyclonal Antibody

 Product Synonym Names    B7-H; B7H1; MGC142294; MGC142296; PD-L1; PDCD1L1; PDCD1LG1; PDL1
 Product Gene Name   

anti-CD274 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605402
 3D Structure    ModBase 3D Structure for Q9NZQ7
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human CD274
 Calculated Molecular Weight    33kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-CD274 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD274 antibody

   Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
 Product Categories/Family for anti-CD274 antibody    Polyclonal
 Applications Tested/Suitable for anti-CD274 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CD274 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-CD274 antibody    Western blot analysis of extracts of various cell lines, using CD274 antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
anti-CD274 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CD274. It may not necessarily be applicable to this product.
 NCBI GI #    83287884
 NCBI GeneID    29126
 NCBI Accession #    Q9NZQ7.1 [Other Products]
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 UniProt Primary Accession #    Q9NZQ7 [Other Products]
 UniProt Secondary Accession #    Q14CJ2; Q2V8D5; Q66RK1; Q6WEX4; Q9NUZ5; B2RBA2; B4DU27 [Other Products]
 UniProt Related Accession #    Q9NZQ7 [Other Products]
 Molecular Weight    290
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 NCBI Official Full Name    Programmed cell death 1 ligand 1
 NCBI Official Synonym Full Names    CD274 molecule
 NCBI Official Symbol    CD274 [Similar Products]
 NCBI Official Synonym Symbols   
B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1
[Similar Products]
 NCBI Protein Information    programmed cell death 1 ligand 1; B7 homolog 1; CD274 antigen; PDCD1 ligand 1; programmed death ligand 1
 UniProt Protein Name    Programmed cell death 1 ligand 1
 UniProt Synonym Protein Names   
B7 homolog 1; B7-H1; CD_antigen: CD274
 Protein Family    Programmed cell death
 UniProt Gene Name    CD274 [Similar Products]
 UniProt Synonym Gene Names    B7H1; PDCD1L1; PDCD1LG1; PDL1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7-H1 [Similar Products]
 UniProt Entry Name    PD1L1_HUMAN
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 UniProt Comments for CD274    CD274: Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p24

Cellular Component: plasma membrane; integral to membrane; endomembrane system; external side of plasma membrane

Molecular Function: protein binding

Biological Process: regulation of activated T cell proliferation; cell surface receptor linked signal transduction; negative regulation of interleukin-10 production; negative regulation of interferon-gamma production; negative regulation of activated T cell proliferation; T cell costimulation; immune response; positive regulation of T cell proliferation; signal transduction
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 Research Articles on CD274    1. The recent development of the checkpoint inhibitors anti-programmed death-1 and anti-programmed death ligand-1 has generated an enormous amount of interest as a potential new anticancer strategy in solid tumors
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD274 antibodyPathways associated with anti-CD274 antibody
 Reference Product  PubMed Publications
 CD80 antibody  >391 publications with CD274 and CD80
 PDCD1 antibody  >330 publications with CD274 and PDCD1
 STAT1 antibody  >12 publications with CD274 and STAT1
 PTEN antibody  >10 publications with CD274 and PTEN
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 PD-1 Signaling Pathway antibodies  PD-1 Signaling Pathway Diagram
Diseases associated with anti-CD274 antibodyOrgans/Tissues associated with anti-CD274 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >109 publications with CD274 and Inflammation
 Liver Diseases Antibodies  >86 publications with CD274 and Liver Diseases
 Necrosis Antibodies  >74 publications with CD274 and Necrosis
 Nervous System Diseases Antibodies  >70 publications with CD274 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >69 publications with CD274 and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >63 publications with CD274 and Adenocarcinoma
 Lung Diseases Antibodies  >45 publications with CD274 and Lung Diseases
 Kidney Diseases Antibodies  >44 publications with CD274 and Kidney Diseases
 Lung Neoplasms Antibodies  >41 publications with CD274 and Lung Neoplasms
 Recurrence Antibodies  >26 publications with CD274 and Recurrence
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >772 publications with CD274 and Blood
 Lymph Node Antibodies  >79 publications with CD274 and Lymph Node
 Lung Antibodies  >71 publications with CD274 and Lung
 Bone Antibodies  >62 publications with CD274 and Bone
 Skin Antibodies  >45 publications with CD274 and Skin
 Brain Antibodies  >31 publications with CD274 and Brain
 Pancreas Antibodies  >28 publications with CD274 and Pancreas
 Placenta Antibodies  >19 publications with CD274 and Placenta
 Stomach Antibodies  >13 publications with CD274 and Stomach
 Mouth Antibodies  >9 publications with CD274 and Mouth
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